
Mushrooms are a nutrient-dense food that offers unique health benefits. They are rich in phytonutrients, antioxidants, protein, fiber, healthy carbs, and vitamins. All types of mushrooms are considered paleo because they are found in nature, are unprocessed, and have been consumed for many years. They are also known to be anti-inflammatory and have been used medicinally for thousands of years. Mushrooms are also considered to have powerful effects on the immune system, which has implications for the management of autoimmune diseases. While whole mushrooms are included in the Autoimmune Protocol, mushroom extracts are considered a gray area and more research is needed to confirm their benefits for autoimmune disease sufferers.
| Characteristics | Values |
|---|---|
| Paleo-friendly | Yes |
| Autoimmune-friendly | Medicinal mushroom extracts are considered an AIP grey area; newer studies suggest they are more likely immunomodulatory than immunostimulatory |
| Health benefits | Nutrient-dense, high in antioxidants, anti-inflammatory, anti-cancer, anti-bacterial, anti-viral, anti-fungal, high in fiber, and rich in vitamins |
| Types | Cremini, button, Portobello, shiitake, reishi, maitake, oyster, enoki, puffballs, boletus, chanterelles, truffles, morels |
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What You'll Learn

Mushrooms are considered paleo
Mushrooms are also encouraged in unlimited quantities for most paleo diets. Each type of mushroom has a different taste, which can add variety to one's diet. They are also a great substitute for meat due to their chewy texture. Mushrooms have been eaten for medicinal purposes for thousands of years, especially in the East. They are considered a "'super food'" by many people today.
Different varieties of mushrooms have different health benefits. For example, white mushrooms are great for weight loss and prostate cancer prevention, while shiitake mushrooms are helpful in fighting harmful tumors and have anti-inflammatory properties. Reishi mushrooms are considered a "super food" due to their anti-cancer, antioxidant, antibacterial, antiviral, and antifungal properties. Maitake mushrooms help to identify abnormal cells and cause them to self-destruct, which is beneficial for fighting cancerous cells. Oyster mushrooms may help defend the body against viruses like HIV and are also anti-inflammatory and high in antioxidants.
Mushrooms are also an incredibly valuable nutrient-dense food that offers our gut bacteria unique fiber types that cannot be found in other foods. They are also known to have potent anti-inflammatory properties. Some beta-glucans found in mushrooms can bind to immune cells directly, affecting immune activity in addition to the indirect effects mediated by the gut microbiome. While there was a rationale for avoiding medicinal mushroom extracts on the Autoimmune Protocol, newer studies reveal that medicinal mushrooms are more likely to be immunomodulatory rather than immunostimulatory.
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Medicinal mushrooms and the immune system
Medicinal mushrooms have been used for hundreds of years, particularly in Asia, to treat infections, lung diseases, and cancer. They are also known to help our cardiovascular system. They have been considered a "food of the gods" and a "health food". Today, medicinal mushrooms are approved as an addition to standard cancer treatments in Japan and China.
Medicinal mushrooms are rich in nutrients and disease-preventing abilities. They offer important phytonutrients, antioxidants, protein, fiber, healthy carbs, and vitamins. They are also a great source of unique gut bacteria. Mushrooms are also anti-inflammatory, with several medicinal mushroom polysaccharides demonstrating anti-inflammatory activity, including terpenoids, phenols, polysaccharides, and proteoglucans.
Medicinal mushrooms are also known to have anti-cancer effects. Polysaccharide K (PSK), for example, is an approved mushroom product used to treat cancer in Japan. PSK has been studied in patients with gastric cancer, breast cancer, colorectal cancer, and lung cancer. It has been used as adjuvant therapy in thousands of cancer patients since the mid-1970s. Maitake is a culinary and medicinal mushroom that has shown anti-cancer activity on breast cancer, melanoma, and hepatoma cells in animal studies.
Medicinal mushrooms are also being studied to find out how they affect the immune system. Certain mushrooms may positively influence the gut microbiota, improving protection against pathogens. Several mushrooms have been shown to support immune health by enhancing innate and adaptive immune responses. However, certain mushroom extracts may also suppress the immune response, thereby exerting anti-allergic effects.
Medicinal mushrooms have also been studied for their effects on autoimmune diseases. Reishi, for example, has been studied in patients with rheumatoid arthritis and shown to decrease joint pain. A mouse study of lupus demonstrated that reishi extract supplementation caused a decrease in autoantibodies and increased survival.
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Mushrooms and autoimmune diseases
Mushrooms are considered a valuable source of nutrients and have been consumed for medicinal purposes for thousands of years. They are rich in phytonutrients, antioxidants, protein, fiber, healthy carbohydrates, and vitamins. They also contain polysaccharides, which have been associated with anti-inflammatory and immunomodulatory effects.
While mushrooms have been praised for their health benefits, there are some considerations when it comes to autoimmune diseases. Autoimmune diseases are conditions in which the immune system mistakenly attacks healthy cells in the body. People with autoimmune diseases must be cautious about substances that stimulate the immune system. Initially, medicinal mushroom extracts were avoided in the Autoimmune Protocol due to their potential immune-stimulating properties. However, recent studies suggest that medicinal mushrooms may have immunomodulatory effects, helping to restore balance to an imbalanced immune system.
Reishi mushrooms, in particular, have been studied for their potential benefits in autoimmune diseases. In mouse studies of lupus, reishi extract supplementation resulted in decreased autoantibodies and increased survival. Additionally, in a mouse model of autoimmune Alzheimer's disease, reishi supplementation was associated with reduced disease activity. These findings suggest that reishi mushrooms may be beneficial in cases of overactive immune function, such as autoimmune diseases.
On the other hand, there are some concerns about the use of mushroom supplements in individuals with certain autoimmune conditions. For example, a case report described a patient with autoimmune necrotizing myopathy whose symptoms worsened after taking Asian mushroom supplements (shiitake, maitake, and reishi). Additionally, reishi mushrooms are known to boost the immune system, so they may exacerbate symptoms in people with autoimmune conditions who are taking immunosuppressant medications. Therefore, it is crucial for individuals with autoimmune diseases to consult with their healthcare providers before consuming mushroom supplements or extracts.
In conclusion, while mushrooms have historically been valued for their medicinal properties and nutritional benefits, their role in autoimmune diseases is more complex. Some studies suggest that certain mushroom extracts may have immunomodulatory effects that could benefit individuals with autoimmune conditions. However, the impact of mushrooms on autoimmune diseases is highly individualized, and more research is needed to fully understand their effects. As such, it is essential for those with autoimmune diseases to seek personalized advice from healthcare professionals before incorporating mushroom supplements into their regimens.
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Mushrooms as a substitute for meat
Mushrooms are a great substitute for meat, especially in terms of texture and flavour. They are versatile and can be used in a variety of dishes, from stir-fries to sandwiches, stews, and even as a meat alternative in a classic burger.
Portobello mushrooms, for example, are a popular choice for vegetarians and can be used in place of meat in stews, sandwiches, tacos, fajitas, and more. They have a chewy texture and can be grilled or stuffed with beans and veggies.
Oyster mushrooms are another excellent option, as they can be used to mimic the texture and appearance of chicken. They can be peeled apart into layers that resemble thin pieces of chicken breast. King oyster mushrooms, in particular, can be sliced into thin strips and used as a shredded meat substitute in stir-fries or even as a beef jerky alternative.
Shiitake mushrooms are also a good meat substitute, adding a soft texture and meaty flavour to dishes like stir-fries and soups. Cremini mushrooms, which are similar to white button mushrooms, are another versatile option that can be used in pasta sauce, on pizza, or in place of beef in stews.
While mushrooms may not be a one-to-one protein substitute for meat, they can be combined with other plant-based protein sources like beans, tempeh, tofu, or seitan to create a balanced meal. They are low in calories and offer a range of nutritional benefits, including anti-inflammatory properties, antioxidants, and vitamins.
In terms of preparation, mushrooms can be sliced, chopped, or left whole depending on the dish. Marinades and high-temperature cooking can also enhance their flavour and texture, making them an even more appealing meat alternative.
Overall, mushrooms are a tasty, nutritious, and versatile option for those looking to reduce their meat consumption or adopt a more plant-based diet.
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Mushrooms are nutrient-dense
Mushrooms are also rich in non-nutritive plant substances, including polysaccharides, indoles, polyphenols, and carotenoids, which have been shown to have antioxidant, anti-inflammatory, and anticancer effects. The antioxidant properties of mushrooms help to fight damaging free radicals in the body, reducing the risk of chronic diseases like cancer and heart disease.
Mushrooms are the only non-animal source of vitamin D, which is produced when ergosterol, a unique sterol found in fungi, is exposed to ultraviolet light. This makes mushrooms a valuable food for those following a vegetarian or vegan diet.
In addition to their nutritional benefits, mushrooms are also prized for their culinary characteristics. They are low in calories and fat, making them a suitable substitute for meat in dishes. Their texture and umami or savoury flavour add depth and richness to meals. Cooking techniques such as roasting and searing can enhance the umami flavour of mushrooms.
Mushrooms have been consumed for thousands of years, both as food and for their medicinal properties. Ancient civilisations, including the Greeks, Egyptians, Romans, and Chinese, valued mushrooms for their health benefits and culinary appeal. Today, mushrooms are recognised as a valuable component of a healthy diet, offering unique nutrients and disease-preventing abilities.
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Frequently asked questions
Yes, all types of mushrooms are considered paleo. They are unprocessed, found in nature, and have been consumed for many years.
While mushrooms are considered paleo, there is some debate about whether they are suitable for the Autoimmune Protocol (AIP). Medicinal mushroom extracts were traditionally avoided on AIP due to their potential impact on the immune system. However, newer studies suggest that medicinal mushrooms may have immunomodulatory effects, which could benefit those with autoimmune diseases. Therefore, while whole mushrooms are generally considered AIP-friendly, mushroom extracts remain in a gray area.
Mushrooms are a valuable source of unique nutrients, including phytonutrients, antioxidants, protein, fiber, healthy carbs, and vitamins. They are also low in calories and filling, making them a great meat substitute. Additionally, different varieties of mushrooms offer specific health benefits, such as anti-inflammatory and anti-cancer properties.
No significant concerns have been highlighted regarding the consumption of whole mushrooms on a paleo diet. However, as with any diet, it is essential to practice moderation and ensure a balanced intake of various foods.
Mushrooms are versatile and can be prepared in various ways. They can be roasted, stuffed, or added to stir-fries and omelets. They also make a great meat substitute in dishes like Portobello burgers or "zhoozhy" side dishes like Roasted Balsamic Mushrooms.

























