
Mushrooms have been used as food and medicine for thousands of years. They are rich in anti-inflammatory components, such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins and biometals. They also contain phenols and other antioxidants that provide anti-inflammatory protection. Certain mushrooms have been found to reduce the production of inflammatory mediators through the downregulation of gene expression. The activation of macrophages with mushroom extracts has been shown to induce T cell production of TNF-α and IFN-γ, boosting immune responses and improving anti-cancer immunity. With their nutritional and medicinal value, mushrooms are an important component of folk medicine and a potential natural source of anti-inflammatory compounds for medical applications.
| Characteristics | Values |
|---|---|
| Medicinal value | Mushrooms have been used as medicine for thousands of years. |
| Nutritional value | Mushrooms are rich in anti-inflammatory components, such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins, biometals, selenium, copper, and all of the B vitamins. |
| Anti-inflammatory properties | Mushrooms contain phenols and other antioxidants that provide anti-inflammatory protection. |
| Cancer prevention | Mushrooms have been used as a natural source of anti-inflammatory compounds to suppress the production of inflammatory mediators and prevent cancer. |
| Immunity | Mushrooms have been shown to modulate immunity and stimulate the immune system in vitro and in vivo. |
| Health benefits | Mushrooms are very low in calories and can help improve health. |
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What You'll Learn

Mushrooms have been used as medicine for thousands of years
The ancient Greeks, for example, used the amadou mushroom as a potent anti-inflammatory and for cauterizing wounds. In ancient China, mushrooms were used as early as the Han Dynasty (202 BC – 220 AD), and their use later spread to other parts of Asia, including Japan and Korea, where they were incorporated into traditional medicine. Ötzi, the 5300-year-old Ice Man, carried amadou and birch polypore mushrooms in a pouch to help him survive in the Alps of northern Italy. The First Peoples of North America also used puffball mushrooms as wound healers.
Medicinal mushrooms have traditionally been used to combat inflammation and fight infections. Prolonged inflammation is associated with various inflammatory diseases, including juvenile idiopathic arthritis, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, gastritis, bronchitis, and atherosclerosis. Certain mushrooms have been found to decrease the activities of inflammatory mediators, thereby inhibiting macrophage functions and reducing cell inflammations.
In addition to their anti-inflammatory properties, mushrooms have been used to improve immune function, fight cancer cells, lower cholesterol levels, and enhance cognitive function. Modern science has also recognised the functional qualities of medicinal mushrooms, and they are now used as dietary food, dietary supplements, and a new class of drugs called 'mushroom pharmaceuticals'.
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Mushrooms contain anti-inflammatory compounds
Mushrooms have been used for thousands of years in traditional medicine for their nutritional and medicinal value. Modern research confirms the therapeutic effects of many species of mushrooms. Mushrooms are a potential natural source of anti-inflammatory compounds for medical applications. Prolonged inflammation can cause inflammatory diseases such as juvenile idiopathic arthritis (JIA), inflammatory bowel disease (IBD), multiple sclerosis, rheumatoid arthritis, gastritis, bronchitis, and atherosclerosis.
Mushrooms contain many bioactive metabolites, which are used to make medicines, especially in Africa, the Middle East, China, and Japan. The anti-inflammatory compounds in mushrooms include polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules. Mushrooms also contain bioactive components such as beta-glucans and ergothioneine, which exhibit potent anti-inflammatory activities. Beta-glucans, a polysaccharide found in edible mushrooms, are known for their ability to modulate the immune response, helping the body fight against diseases. Ergothioneine, an antioxidant, helps protect cells in the body from damage.
The activation of the macrophage with mushroom extracts stimulates T cell production of TNF-α and IFN-γ and very little IL-10. This pattern of immuno-regulation by mushrooms is consistent with a model whereby whole mushroom consumption would induce a modest but important boost in immune responses that would improve anti-cancer immunity. In macrophage, the inhibition of IL-10 and activation of IFN-γ, IL-1β, and TNF-α would result in an activated phenotype for the macrophage that would induce production of T cell and macrophage cytokines like IFN-γ and TNF-α that are important in the clearance of tumorogenic cells, pro-inflammatory signaling, and killing of infectious organisms.
Grifolin and grifolin derivatives are another class of farnesyl phenolic compounds that have been isolated from the edible mushroom Albatrellus ovinus and exhibit anti-inflammatory properties. Grifolins showed significant inhibition of NO production stimulated by LPS in RAW 264.7 cells, with IC50 values ranging between 22.9 and 29 μM. They also inhibited histamine release from rat peritoneal mast cells.
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Mushrooms may help prevent certain cancers
Mushrooms have been used for thousands of years, mainly for their nutritional value as a source of carbohydrates, proteins, amino acids, and minerals. They are also used in traditional medicine in different parts of the world, including Africa, the Middle East, China, and Japan. Modern research confirms the therapeutic effects of traditionally used species.
Mushrooms have been studied for their anti-inflammatory properties and their potential to prevent certain cancers. A study by Penn State College of Medicine researchers found that higher mushroom consumption is associated with a lower risk of cancer. The study analyzed data from more than 19,500 cancer patients and found that individuals who ate 18 grams of mushrooms daily had a 45% lower risk of cancer compared to those who did not consume mushrooms. Mushrooms are rich in vitamins, nutrients, and antioxidants, including the amino acid ergothioneine, which is a potent antioxidant and cellular protector.
Medicinal mushrooms have been used as an adjunct to standard cancer treatments in Asia, particularly in Japan and China. Certain mushrooms are believed to stimulate compounds that suppress tumor formation and decrease inflammatory compounds, which can be beneficial for cancer patients. For example, reishi mushrooms, known as Ling Zhi in traditional Chinese medicine, have been used to strengthen the immune system of cancer patients undergoing chemotherapy or radiation therapy.
While most studies show a positive effect on the immune system, more research is needed to fully understand the role of mushrooms in cancer prevention and treatment. Some studies have shown that cancer patients who consume mushrooms may have improved survival rates, possibly due to increased tolerance to chemotherapy treatments and a positive immune response. However, it is important to note that mushrooms can also cause adverse reactions, such as mild to moderate liver or kidney toxicity.
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Mushrooms are low in calories and rich in selenium, copper, and B vitamins
Mushrooms have been used for thousands of years as food and medicine in different parts of the world. They are neither a plant nor an animal food but are a type of fungus. They have been widely recognised for their nutritional and medicinal value.
Mushrooms are low in calories and fat and contain modest amounts of fibre and nutrients. They are a rich source of selenium, copper, and B vitamins. Selenium can help prevent cell damage in our bodies, and mushrooms are a good dietary source of this mineral. B vitamins found in mushrooms include thiamine, riboflavin, B6, and B12.
Mushrooms are also a source of vitamin D, which is important for cell growth. Mushrooms that have been treated with UV light will be particularly rich in vitamin D. Mushrooms also contain vitamin C, potassium, and choline.
Mushrooms have been shown to have anti-inflammatory effects, which can improve the efficiency of the immune system. They have been used in traditional medicine to treat inflammatory diseases such as arthritis, inflammatory bowel disease, and bronchitis. Modern research confirms the therapeutic effects of mushrooms.
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Mushrooms can be used as a meat substitute
Mushrooms have been used for thousands of years in different parts of the world, owing to their nutritional and medicinal value. They are a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites, which make mushrooms and truffles common components in folk medicine. Modern research confirms the therapeutic effects of mushrooms, including their anti-inflammatory properties.
Mushrooms are an excellent choice for those looking to minimize their ecological footprint while enjoying flavorful, plant-based dishes. They can be used as a meat substitute in various recipes, ranging from stir-fries to soups. For instance, shiitake mushrooms, native to East Asia, are renowned for their rich, umami flavor and distinct smoky notes. Their meaty texture makes them an ideal substitute for meat in vegan recipes. Similarly, oyster mushrooms are known for their meatiness and ability to absorb flavors. They can be used as a substitute for meat in tacos, sandwiches, and chowders.
Lions mane mushrooms are another variety that can be shredded and used as a substitute for crab meat. King oyster mushrooms are also a popular choice for substituting meat in dishes like spicy creamy udon. Mushrooms can be sliced and cooked in olive oil, butter, garlic, and herbs to create a versatile meat substitute that can be added to salads, pastas, or served with side dishes.
Mushrooms are a sustainable and ethical alternative to meat, benefiting both health and taste. They provide a good source of protein and vitamins, making them a nutritious option. However, it is important to note that they may not provide sufficient protein content on their own, and it is recommended to include other protein sources in the diet as well.
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Frequently asked questions
No, mushrooms are rich in anti-inflammatory components, such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins and biometals. Mushrooms have been used as food and medicine for thousands of years.
Examples of anti-inflammatory foods include fruits, vegetables, spices, peppers, green tea, turmeric, and dark chocolate.
Mushrooms contain bioactive metabolites which make them common components in folk medicine, especially in Africa, the Middle East, China, and Japan. The anti-inflammatory compounds of mushrooms include polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules.
Mushrooms have been shown to modulate immunity. They stimulate the production of TNF-α, IFN-γ, and IL-1β while decreasing IL-10. This pattern of immuno-regulation may improve anti-cancer immunity and induce the production of T cell and macrophage cytokines.
Mushrooms can be sautéed quickly over high heat or simmered over low heat in soups, salads, omelets, scrambled eggs, stir-fries, pasta sauces, chilis, or soups. They can also be grilled, like portobello mushroom caps, or added to cooked pasta or whole grains.

























