
Mushrooms are a type of fungus that has long been a staple in many cuisines worldwide. In recent years, the topic of genetically modified organisms (GMOs) has sparked debates in the food industry, with mushroom farmers expressing concern about the potential impact of GMO mushrooms on their businesses. While some companies assert that their mushrooms are not genetically modified, researchers at Penn State University have developed a GMO mushroom using gene-editing techniques like CRISPR-Cas9. This development has raised questions about regulation and labeling, with some GMO mushrooms exempt from regulatory processes, potentially impacting consumer choice and market dynamics.
| Characteristics | Values |
|---|---|
| Are mushrooms GMO? | There is no clear answer to this question. While some sources claim that a researcher at Penn State University has developed a GMO mushroom, others state that the mushroom is not a GMO. |
| GMO mushroom characteristics | The mushroom is gene-edited using CRISPR-Cas9 technology, which makes it anti-browning and gives it a longer shelf life. |
| Regulatory status | The mushroom is not subject to the USDA's regulatory process for GMOs. |
| Commercialization | It is unclear if the mushroom will be commercialized due to public scrutiny of GMOs. |
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What You'll Learn

Mushrooms: GMO or non-GMO?
There has been much debate surrounding the genetic modification of mushrooms and whether they should be classified as GMOs. In recent years, a researcher at Penn State University, Yinong Yang, has developed a new gene-edited mushroom that has sparked controversy in the world of GMOs. This mushroom, created using CRISPR-Cas9 technology, is designed to resist browning and have a longer shelf life. The question of whether this mushroom constitutes a GMO has been at the forefront of the dialogue surrounding its development.
Traditionally, genetic modification involved the insertion of foreign genetic material, such as viruses or bacteria, into an organism. However, Yang's mushroom does not contain any foreign DNA. Instead, it was created using CRISPR-Cas9, a gene-editing technique that does not rely on the introduction of foreign genetic material. Because of this, the U.S. Department of Agriculture (USDA) has ruled that the mushroom is not subject to the regulatory process for GMOs. This decision has been met with mixed reactions, with some anti-GMO advocates expressing disturbance over the prospect of a GMO mushroom bypassing regulatory oversight.
The ruling on Yang's mushroom sets a precedent for future crop modifications. It highlights that not all genetic modifications involve the introduction of foreign DNA, and therefore, not all modified organisms may be subject to the same regulatory processes as traditional GMOs. This decision has significant implications for the future of crop development, as it opens the door for small companies and universities to develop modified crops without facing the same regulatory hurdles as those involving foreign genetic material.
While the debate over the classification of Yang's mushroom as a GMO continues, it is important to note that not all mushrooms on the market are GMO. Many mushroom companies, such as Monterey Mushrooms, do not utilize any genetically modified or engineered spawn (seeds) in their products. Their mushrooms are the result of natural selection and crossing strains for desired attributes. However, with the development of new gene-editing technologies, it is possible that GMO mushrooms could become more prevalent in the future, even if they are not labelled as such.
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CRISPR gene-editing technology
Mushrooms are generally not considered to be genetically modified organisms (GMOs). For instance, Monterey Mushrooms claims that their products are not genetically modified or engineered but are instead the result of natural selection and crossing of strains for desired attributes.
However, in recent years, there have been developments in gene-editing technology, particularly the use of CRISPR (which stands for clustered regularly interspaced short palindromic repeats), that has allowed scientists to modify the genome of mushrooms. CRISPR-Cas9 is a gene-editing technology that can precisely deliver a DNA-cutting enzyme (Cas9) to a targeted region of DNA. This technology can delete or replace specific DNA pieces, thereby promoting or disabling certain traits.
One example of CRISPR-Cas9 being used to modify mushrooms is the work of Yinong Yang, a plant pathologist and associate professor of plant pathology at Penn State University. Yang developed an anti-browning mushroom using CRISPR-Cas9 that has a longer shelf life and resists blemishes from handling and mechanical harvesting. The U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) ruled that this mushroom is not subject to the agency's regulatory process for GMOs because it does not contain foreign DNA from ''plant pests' such as viruses or bacteria.
The USDA's ruling on Yang's mushroom has sparked debate and raised questions about the regulation of GMO crops developed using CRISPR-Cas9 technology. Some people argue that this technology could change the public dialogue about GMOs and open the door for many other GMO crops that resist disease, insects, and drought. However, others are concerned about the lack of oversight and the potential impact on small companies and big corporations. While Yang has filed a provisional patent application on his mushroom, he also recognizes the importance of demonstrating scientifically that a gene-edited crop is safe before bringing it to market.
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Foreign DNA from plant pests
Mushrooms are generally not considered to be genetically modified organisms (GMOs). For example, Monterey Mushrooms claims that their products are not genetically modified or engineered but are instead the result of natural selection and crossing of strains for desired attributes.
However, there has been some debate regarding the classification of certain mushrooms, such as the anti-browning mushroom developed by Penn State researcher Yinong Yang. This mushroom was created using CRISPR-Cas9 gene-editing technology to improve shelf life and resistance to handling and mechanical harvesting. Despite this, the United States Department of Agriculture (USDA) ruled that it was not subject to the same regulatory process as GMOs because it did not contain foreign DNA from other organisms, a typical characteristic of GMO crops.
The discussion surrounding this mushroom highlights an important distinction in the GMO dialogue: the presence or absence of foreign DNA. Foreign DNA refers to DNA that is introduced into an organism from an external source, such as bacteria or other plant species. While most GMO crops contain foreign DNA, the anti-browning mushroom was created using a gene-editing technique that did not involve the addition of foreign genetic material.
In the context of plant pests, the discovery of gene transfer from plants to insects has been documented. For example, a study found that a whitefly species had acquired a gene from its plant host, allowing it to evade the host's defences. This knowledge may lead to the development of new pest control strategies. Additionally, research has shown that plant DNA can be detected in the guts of insect larvae, such as Agriotes wireworms, for up to 72 hours after feeding. These findings contribute to our understanding of plant-insect interactions and may have implications for pest management in agricultural settings.
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The future of GMO mushrooms
Mushrooms are not considered genetically modified organisms (GMO) as they are the result of natural selection and crossing of strains for desired attributes. However, a researcher at Penn State University has recently developed a new GMO mushroom using a gene-editing technique known as CRISPR-Cas9. This technology has the potential to create crops with desirable traits such as longer shelf life, low levels of food allergens or toxins, disease resistance, drought tolerance, and efficient nitrogen and phosphorus utilization.
Additionally, there is a lack of transparency and labeling regulations regarding GMO mushrooms. Sen. Pat Roberts (R-Kan.) and his fellow opponents of GMO labeling in the Senate are pushing for legislation that would prohibit states and the federal government from requiring mandatory labeling of GMO foods. This means that Americans may never know if the mushrooms they are buying are GMO, which takes away their choice and goes against the preference of 90% of Americans who support on-package labeling of GMO food.
The development of GMO mushrooms also sparks debates about the safety and ethical implications of gene-editing technology. While some people express concern about the potential risks of consuming GMO crops, others argue that this technology can facilitate dialogue among diverse groups with a common goal of achieving food safety, security, and sustainability.
In conclusion, the future of GMO mushrooms is uncertain. While this new technology offers potential benefits in terms of crop improvement and sustainability, there are also concerns about the impact on farmers, consumer choice, and food safety. As with any new technology, it is essential to carefully consider the potential risks and benefits before widespread adoption.
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Non-GMO mushroom companies
Mushrooms are increasingly being recognised for their health benefits, and companies are now offering mushroom-based products in a variety of forms, including powders, capsules, gummies, beverages, and supplements.
Some companies that offer non-GMO mushroom products include Om Mushrooms, Host Defense Mushrooms, and Aloha Medicinals.
Om Mushrooms
Om Mushrooms was founded by Sandra Carter, a health and wellness expert with a PhD in preventative medicine, and Steve Farrar, a mycologist with over 30 years of experience growing mushrooms. The company grows 10 species of mushrooms in its Certified Organic, BRCGS AA-rated facility in Vista, California. Om Mushrooms offers a range of organic mushroom products in the form of powders, capsules, gummies, and beverages. Their products are non-GMO and third-party lab-tested, ensuring the highest quality and safety standards.
Host Defense Mushrooms
Host Defense Mushrooms is a company founded by Paul Stamets, with a focus on harnessing the power of mushrooms for human health. Their mushroom mycelium and fruit bodies are grown on their certified organic farm in Washington State. Host Defense Mushrooms is the best-selling mushroom supplement brand in the U.S., offering non-GMO, vegan, and gluten-free products. Their formulations are based on scientifically proven data, ensuring quality and safety.
Aloha Medicinals
Aloha Medicinals is a leading provider of organic functional mushrooms and mushroom supplements. They have one of the largest privately held strain banks in the world, with over 1,200 unique DNA-verified strains. Their mushrooms are grown and manufactured in Carson City, Nevada, using sustainable practices and 100% organic, US-grown sorghum. Aloha Medicinals prioritises growing their mushrooms in a clean, controlled environment, conducting heavy metal testing and rigorous quality checks to ensure the purity and safety of their products.
Other companies that offer mushroom supplements and claim to have high standards for quality and purity include Real Mushrooms and Fungi Perfecti. These companies emphasise the use of pure, organic mushroom extracts, backed by scientific research, to provide consumers with trusted and effective products.
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Frequently asked questions
Mushrooms are not considered GMO as they do not contain foreign DNA from 'plant pests' such as viruses or bacteria. However, there is a new gene-edited mushroom developed by a Penn State researcher that has received a lot of attention and sparked debates about GMO. This mushroom is transgene-free, created using CRISPR- Cas9 gene-editing technology, and is not subject to USDA approval.
GMO mushrooms are created by genetically modifying the mushroom spawn (seed) to include foreign genetic material, whereas non-GMO mushrooms are the result of natural selection and crossing of strains for desired attributes.
Non-GMO mushrooms are naturally grown without any genetic modification, which some consumers may prefer. Additionally, non-GMO mushrooms may be preferred by farmers who sell their produce into markets that do not accept GMOs, such as organic markets.
You can find non-GMO mushrooms at specialty food stores, farmers' markets, and some grocery stores. Look for labels or certifications that indicate the mushrooms are non-GMO or organically grown.

























