
Psilocybin, also known as magic mushrooms, is a hallucinogenic chemical found in certain mushrooms. It is a psychedelic drug that can affect all the senses, altering a person's thinking, sense of time, and emotions. On the other hand, phencyclidine, commonly known as PCP, is a synthetic drug that was originally developed as an anesthetic but is no longer used medically due to its serious side effects. While both psilocybin and PCP can induce hallucinations, they are distinct substances with different chemical structures and effects on the body and brain. This paragraph introduces the topic of psilocybin (magic mushrooms) and sets the context for understanding its relationship or differences with phencyclidine (PCP) as hallucinogenic substances.
| Characteristics | Values |
|---|---|
| What are mushrooms? | Psilocybin or magic mushrooms are naturally occurring and are consumed for their hallucinogenic effects. |
| How do they work? | Psilocybin is converted in the body to psilocin, which is the chemical with psychoactive properties. |
| How are they consumed? | Mushrooms are typically consumed dried or powdered. They can be cooked, boiled into a drink, eaten raw, or covered in chocolate. |
| Effects | Hallucinations, an altered perception of time, and an inability to distinguish fantasy from reality. |
| Addiction | There is no data on the safety of taking psilocybin during pregnancy. However, current research suggests that psilocybin is not addictive, and no physical symptoms occur after stopping use. |
| Side effects | "Bad trips" may cause frightening hallucinations, terror, depression, or panic attacks. |
| PCP | PCP stands for phencyclidine. It is a hallucinogenic drug that was developed as an intravenous anesthetic but is no longer used medically due to serious side effects. |
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What You'll Learn

Hallucinogenic effects of psilocybin mushrooms
Psilocybin, the active chemical in hallucinogenic mushrooms, has hallucinogenic effects that alter a person's perception of reality. Psilocybin mushrooms, also known as magic mushrooms, are typically consumed dried, powdered, cooked, or brewed into tea. They can also be eaten raw or fresh and covered in chocolate to mask their bitter flavour.
Psilocybin works by binding to and activating serotonin receptors in parts of the brain that affect mood, cognition, and perception, such as the prefrontal cortex and amygdala. The hallucinogenic effects of psilocybin usually occur within 30 minutes of ingestion and can last between four and six hours. The effects include hallucinations, an altered perception of time and space, and intense changes in mood and feelings. People may see colours, shapes, or scenes, hear things that aren't real, or lose their sense of time and space. They may also have a mystical experience, entering a dreamlike, euphoric state with visions or reliving memories.
The effects of psilocybin mushrooms can vary depending on individual factors such as personality, expectations, age, biology, sex, and history of drug use. Regular use of psilocybin mushrooms can lead to tolerance, and higher doses or anxiety may increase the risk of a "bad trip", which can include frightening hallucinations, terror, depression, or panic attacks. While psilocybin is not considered addictive, some users may experience mild psychological withdrawal effects or fatigue.
Psilocybin mushrooms have a long history of use, dating back thousands of years for spiritual and healing rituals. There is renewed interest in their potential therapeutic benefits for treating conditions such as depression, anxiety, addiction, PTSD, and other mental health disorders. However, it is important to note that psilocybin mushrooms are illegal in many places, and there are risks associated with their use, including accidental poisoning from misidentifying poisonous mushrooms.
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Phencyclidine (PCP) vs. psilocybin
Phencyclidine (PCP) and psilocybin are both hallucinogens, or psychedelics, which are a group of drugs that alter a person's perception of reality and change their awareness of their surroundings. However, despite their similar drug classification, the two substances differ in various ways.
Psilocybin is the active chemical in "magic mushrooms" or "shrooms", which are consumed dried, powdered, cooked, raw, or brewed as tea. These mushrooms have been used for thousands of years by indigenous people in Central America for spiritual and healing rituals. Psilocybin can induce hallucinations, impair judgment, and distort one's perception of time, often causing users to be unable to distinguish fantasy from reality. It is also known to induce mystical experiences, where users enter a dreamlike, euphoric state, and may feel a sense of "oceanic self-boundlessness". While psilocybin is currently illegal, it has been the subject of renewed interest in its potential therapeutic effects on mental health disorders such as depression, anxiety, and obsessive-compulsive disorder (OCD).
On the other hand, PCP is a synthetic drug that was initially developed as an intravenous anesthetic in the 1950s but was discontinued due to its adverse effects. It is now primarily used as a recreational drug and is known by various street names, including angel dust, killer weed, and rocket fuel. PCP is typically ingested by smoking, sniffing, injecting, or swallowing in pill or liquid form. PCP use can cause users to feel detached from their surroundings, induce hallucinations, and lead to severe mood swings, paranoia, and psychotic behaviour. Long-term use of PCP can result in memory loss, thinking problems, and problems with speech. Additionally, PCP has been associated with an increased risk of suicide attempts and the development of psychological addiction.
In summary, while both psilocybin and PCP are classified as hallucinogens or psychedelics, they differ in their sources, methods of ingestion, and specific effects on the user. Psilocybin is derived from certain types of mushrooms and has a long history of traditional use, whereas PCP is a synthetic drug initially developed for medical purposes but now primarily used recreationally. The effects of psilocybin are often characterized by distortions in perception and mystical experiences, while PCP induces feelings of detachment, hallucinations, and severe mood alterations. Additionally, long-term PCP use carries greater health risks, including cognitive and psychological complications.
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History of psilocybin use
Psilocybin, an indole-based secondary metabolite produced by numerous species of mushrooms, has a long history of use that dates back to prehistoric times. Archaeological evidence suggests that indigenous cultures worldwide have recognised the spiritual and healing potential of psilocybin mushrooms for thousands of years.
Ancient History
The heartland of psilocybin history is Central America, where evidence of mushroom worship among the Aztecs dates back to at least 1000 BCE. Known as "teonanácatl" or "flesh of the gods", these sacred fungi were consumed during religious ceremonies and psychedelic tea rituals. Spanish chroniclers in the 16th century documented these practices, often misinterpreting them through their religious beliefs. Despite attempts to suppress these traditions, the use of psilocybin in ceremonies persisted and was passed down through generations by indigenous shamans and healers.
Outside of Central America, evidence of psilocybin use in ancient times is scarce. Cave paintings and rock art in modern-day Algeria and Spain suggest that human use of psilocybin mushrooms may predate recorded history. In Europe, there are a few accounts mentioning psilocybin mushrooms, such as Flemish botanist Carolus Clusius's description of the "crazy mushroom" in rural Hungary. However, these early accounts often lack details for species identification.
Modern History
In the 20th century, psilocybin gained attention in the Western world through the writings of a 16th-century Spanish Franciscan friar and historian, which sparked a search for the identity of "teonanácatl". In 1957, a photo essay in a popular magazine described the use of these mushrooms, and specimens were obtained for study. Swiss chemist Albert Hofmann isolated psilocybin and psilocin from Psilocybe mexicana in 1958, and his employer, Sandoz, marketed and sold pure psilocybin for psychedelic therapy worldwide.
In the 1960s, psilocybin mushrooms became popular in the United States, with American researchers studying their healing properties and medical applications. Timothy Leary, a Harvard professor, promoted the use of psilocybin mushrooms, coining the phrase "turn on, tune in, and drop out". This endorsement, along with the rise of the hippie movement, led to nationwide attention and a counterculture movement that threatened traditional societal values. President Richard Nixon responded with the War on Drugs, which resulted in the classification of psilocybin mushrooms as a Schedule I substance under the Controlled Substances Act of 1970. This halted research on psilocybin and contributed to decades of legal prohibition.
Recent Developments
In recent years, there has been a global shift towards decriminalisation and therapeutic legalisation of psilocybin. Cities like Denver, Oakland, and Colorado have decriminalised psilocybin possession, and Oregon legalised its therapeutic use under state-regulated conditions in 2020. Psilocybin-assisted therapy is now being studied as a possible treatment for various psychiatric disorders, including depression, substance use disorders, and obsessive-compulsive disorder.
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Preparing and consuming psilocybin mushrooms
Psilocybin mushrooms, also known as magic mushrooms, shrooms, or liberty caps, are a wild variety of mushrooms that have hallucinogenic effects on the human brain. They are consumed for their psychedelic effects, which can include perceptual changes, heightened emotions, and a distortion of one's sense of time. Visual distortions and hallucinations are also common.
Firstly, it is important to understand dosing, set, and setting before consuming psilocybin mushrooms. They are typically consumed in dried form, and due to their strong flavour, some people prefer to grind them and consume them in capsules. However, there are several other methods of preparation and consumption to consider:
- Brewing tea: Mushrooms can be brewed into tea, which can lead to a milder high that comes on slower and recedes faster, making it a potentially better option for novice consumers.
- Consuming with food: Psilocybin mushrooms can be added to food to mask their bitter flavour. However, exposing them to high temperatures (above 70°C) can destroy the active compounds and reduce their effects. Consuming mushrooms with food can also mitigate their effects, so this method may be disappointing for those seeking a profound psychedelic experience.
- Lemon tek: This method involves grinding the mushrooms and mixing them with lemon juice to convert the psilocybin into psilocin before ingestion, leading to a rapid and potent uptake. This experience can be very intense, so it is recommended to start with a lower dose when trying this method for the first time.
- Eating whole: Mushrooms can also be consumed by simply chewing and swallowing them. This method allows the psilocybin to convert into psilocin in the stomach before passing through the liver and entering the bloodstream, resulting in a slower onset and more moderate effects.
It is important to note that the consumption of psilocybin mushrooms may have physical and psychological effects, including nausea, vomiting, muscle weakness, lack of coordination, hallucinations, and panic reactions. The experience can vary depending on individual factors, and consuming mushrooms on an empty stomach can intensify the experience.
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Safety concerns and side effects of psilocybin mushrooms
Psilocybin, the active chemical in some hallucinogenic mushrooms, has a wide range of effects on the human body. While it is being studied for its potential therapeutic uses, there are several safety concerns and side effects associated with its consumption.
Safety Concerns
There are several safety concerns related to the consumption of psilocybin mushrooms:
- Poisoning: In the wild, people may mistake psilocybin mushrooms for other mushrooms that are poisonous.
- Incorrect Identification: Many species of mushrooms look alike, making it difficult to distinguish between them.
- Addiction: While current research does not indicate that psilocybin is addictive, it is classified as a Schedule I substance by the Drug Enforcement Administration (DEA), indicating a potential for abuse and no legitimate medical purpose.
- Bad Trips: Psilocybin can cause "bad trips", leading to frightening hallucinations, terror, depression, or panic attacks.
- Pre-existing Conditions: Individuals with pre-existing psychiatric or cardiac conditions may experience elevated risks and harmful side effects, such as increased blood pressure and heart rate.
- Lack of Standardization: The lack of approved therapeutic products containing psilocybin means that the safety, efficacy, and quality of psilocybin products have not been assessed or scientifically reviewed.
Side Effects
The side effects of consuming psilocybin mushrooms can vary widely and may include:
- Hallucinations: Psilocybin is a hallucinogen that can cause visual or auditory hallucinations and distort how individuals perceive objects and people in their environment.
- Altered Perception: Individuals may experience an altered sense of reality, seeing, hearing, and feeling things that are not real, or having an altered perception of time and space.
- Euphoria: Psilocybin can induce feelings of euphoria and sensory distortion, similar to other hallucinogenic drugs like LSD.
- Increased Blood Pressure and Heart Rate: Short-term effects of psilocybin can include increased blood pressure and heart rate, which could be harmful to individuals with cardiac diseases.
- Tolerance: With regular use, individuals may develop tolerance to the effects of psilocybin, requiring higher doses to achieve the desired effects.
- Mood Changes: Psilocybin can induce rapid, intense mood swings and changes in thoughts and feelings.
- Impaired Judgment: Consumption of psilocybin mushrooms can result in impaired judgment and unpredictable, potentially dangerous behavior.
It is important to note that the effects of psilocybin mushrooms can be influenced by various factors, including the quantity consumed, an individual's past experiences, expectations, age, biology, sex, and history of drug use. While there is ongoing research into the therapeutic potential of psilocybin, it is currently classified as illegal in many places, and individuals should exercise caution and seek professional guidance before considering its consumption.
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Frequently asked questions
Psilocybin, also known as magic mushrooms, is a naturally occurring, psychedelic drug that can affect all the senses, altering a person’s thinking, sense of time and emotions. It is found in certain types of mushrooms and is consumed for its hallucinogenic effects.
The effects of magic mushrooms vary widely. They can range from euphoria to hallucinations, heightened sensory awareness, impaired judgment, and an altered perception of time. They can also cause a ""bad trip", which may induce frightening hallucinations, terror, depression, or panic attacks.
According to current research, magic mushrooms are not addictive and no physical symptoms occur after stopping use. However, regular use may cause people to become tolerant to the effects of psilocybin. Further research is needed to understand all the factors that influence this risk.
Consuming magic mushrooms can lead to unpredictable, potentially dangerous behavior, which may result in injuries. Regular users may also experience flashbacks, which are usually visual distortions involving changes in emotions or perception. Additionally, there is a risk of poisoning from picking and consuming the wrong types of mushrooms.

























