
Mushrooms have long been a source of fascination for humans, and it turns out that we may have more in common with them than we think. Mushrooms are part of the fungal kingdom, and while they may look very different from humans, we share more genetic traits with mushrooms than with plants. In fact, humans share about a quarter to nearly half of their DNA with fungi. This kinship goes beyond genetics, with mushrooms also offering powerful medicinal and health benefits, as well as potential solutions for sustainability and fighting climate change.
| Characteristics | Values |
|---|---|
| Genetic Similarity | Mushrooms share more DNA with humans than with plants. |
| Carbohydrate Storage | Mushrooms and humans store carbohydrate energy as glycogen, while plants use starch. |
| Motility | Mushrooms can move or crawl, which is achieved through flagella, similar to human sperm cells. |
| Medicinal Properties | Mushrooms have developed medicinal properties, such as boosting immunity, fighting tumors, and supporting brain health. |
| Environmental Impact | Mushrooms demonstrate sustainable solutions by breaking down waste materials, restoring depleted soils, and remediating pollution. |
| Spiritual and Creative Significance | Mushrooms have been revered for their psychedelic properties and their ability to induce dream-like states, inspiring creativity and spiritual exploration. |
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What You'll Learn

Mushrooms and humans share a more recent ancestor than plants
Both mushrooms and humans store carbohydrate energy as glycogen, while plants use starch to store energy. This is one of the major overlapping characteristics shared by fungi and animals that plants do not have. DNA is a complex molecule, and the relationships between different groups of organisms are determined by a range of factors, including molecular, morphological, and ecological data. However, genetic analysis and statistical models have allowed scientists to estimate that mushrooms and humans share a more recent ancestor than plants.
The first hypotheses about the relationship between fungi and animals emerged in the 1950s, and scientists have since tested and confirmed these suspicions. The most recent common ancestor of fungi and metazoa was more recent than the most recent common ancestor shared with plants. The lineage that would become fungi and animals was over a billion years removed from the plant lineage when the first true plants appeared. This is why animals can be considered a specialized lineage of fungi.
Fungi, including mushrooms, demonstrate sustainable solutions through balanced interchange with the environment, just as humans aim to live more regeneratively. They also form vital symbiotic relationships with plant roots through their mycelial networks. This subterranean web allows information and resources to flow between diverse species across vast underground territories. Furthermore, mushrooms possess medicinal properties that work in synergy with the human body. They can boost immunity, fight tumors, lower inflammation, and support brain health.
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Fungi and animals share genetic characteristics
Mushrooms and humans have long been considered to have a lot in common. From their medicinal properties to their ability to induce spiritual exploration, mushrooms have been revered by ancient cultures and modern researchers alike. But are we related to mushrooms?
Fungi, including mushrooms, share a closer genetic relationship with animals than with plants. This was first hypothesized in the 1950s and has since been tested and confirmed by scientists. Fungi and animals share several genetic characteristics that plants do not possess. For instance, both mushrooms and humans store carbohydrate energy as glycogen, whereas plants use starch for energy storage. Additionally, both fungi and insects utilize the polysaccharide chitin for building cell walls, which contrasts with plants' use of cellulose.
These overlapping characteristics suggest that animals and fungi are sister groups, with plants constituting a separate evolutionary lineage. Phylogenetic analyses of protein sequences further support this relationship, indicating that animals and fungi share unique insertions and deletions in specific proteins that are not found in plants, protists, or bacteria.
The Opisthokonta clade includes animals, fungi, and their closest protist relatives, highlighting their close evolutionary relationship. While animals and fungi have significantly diverged from one another, their shared genomic features arose even before the origin of their respective kingdoms. This indicates that the genetic similarities between fungi and animals are ancient and fundamental to our understanding of their evolutionary history.
In conclusion, fungi and animals, including humans and mushrooms, do share genetic characteristics. While the specific implications of these shared traits are still being explored, it is clear that fungi and animals are more closely related to each other than they are to plants. This knowledge contributes to our understanding of the evolutionary trajectories of these kingdoms and the unique adaptations that have arisen in each group.
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Mushrooms have medicinal properties
Mushrooms are more closely related to animals than plants, sharing genetic characteristics with humans. They have been revered by ancient cultures for their psychedelic compounds and ability to induce dream-like states. Today, research on psilocybin and other hallucinogenic compounds in mushrooms shows promise for treating mental health issues and facilitating psychological growth.
Mushrooms also have powerful medicinal properties. They offer a range of health benefits, including anti-inflammatory, antioxidant, antimicrobial, anticancer, and immunomodulatory properties. For example, shiitake mushrooms help to keep cholesterol levels low and lower the risk of developing mild cognitive impairment (MCI), a precursor to Alzheimer's disease.
Research has also found that mushrooms can help alleviate conditions like anxiety and depression. Their healing abilities come from unique protein complexes and polysaccharides that interact with human cells. As herbal remedies, mushrooms offer natural alternatives to support human wellness, working in synergy with our bodies.
Mushrooms are a good source of ergothioneine, an amino acid and antioxidant that prevents or slows cellular damage. They can also help to lower the risk of cancer, with one review finding that eating just 18 grams of mushrooms a day may lower the risk of cancer by up to 45%.
Additionally, mushrooms are a good source of vitamin D, especially when exposed to UV light or sunlight. They also contain prebiotics, which stimulate the growth of healthy bacteria in the gut.
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Mushrooms can induce dream-like states
Mushrooms, specifically the Psilocybe genus, contain the chemical compound psilocybin, which has hallucinogenic effects on the brain. Psilocybin has been used for thousands of years to perturb consciousness and expand the mind.
Psilocybin induces changes in the brain that are similar to what occurs during dreaming. Research by Dr. Carhart-Harris found that psilocybin increases brain function in areas associated with emotion, due to decreased blood flow to the default mode network. This network is responsible for self-reflection, complex mental imagery, and theory of mind. During dreaming, these areas of the brain also exhibit increased functionality. The brain experiences a ""winding down" of higher thought processes, reverting to a more "primitive" state.
The effects of psilocybin are comparable to lucid dreaming, where the subconscious is unlocked, but the individual remains in conscious reality, receiving sensory input from the external world. This is supported by the structural similarity between the DMT molecule, associated with dreaming, and the psilocin molecule, which is orally active.
The dream-like states induced by psilocybin can have therapeutic benefits. By entering a dreamlike state, individuals may be able to address trauma or depression and facilitate psychological growth. Furthermore, psilocybin has shown promise in treating mental health issues, with research suggesting its potential in managing conditions like anxiety and depression.
In summary, mushrooms, specifically those containing psilocybin, can induce dream-like states by altering brain function and mimicking the neurological patterns associated with dreaming. These states have the potential to offer therapeutic benefits, particularly in the realm of mental health.
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Mushrooms can break down waste materials
Mushrooms, or fungi, are more closely related to animals than plants, sharing genetic characteristics with animals that are absent in plants. For instance, mushrooms and animals store carbohydrate energy as glycogen, while plants use starch for energy storage.
Beyond this genetic relationship, mushrooms also play a crucial role in breaking down waste materials. Fungi are often referred to as "nature's recyclers," possessing the unique ability to break down tough materials through their enzymatic secretions and mycelial networks. This process enables mushrooms to colonize and restore depleted soils, remediate pollution, and break down plastics, contributing to the fight against climate change.
The potential of mushrooms in waste management is being explored in various sectors, including agriculture and construction. In agriculture, certain mushroom varieties can grow on agricultural byproducts, reducing the need for fresh inputs. In Marathon County, Wisconsin, researchers are experimenting with growing fungi on oil-contaminated land, aiming to break down petroleum-based contaminants and bring the soil back to life. This process, known as mycoremediation, has also shown promise in decontaminating soil from pesticides and addressing toxic wildfire ash.
The construction industry, facing a waste problem of its own, is turning to mushrooms as a sustainable solution. Tech giant Meta, for example, has partnered with a mycoproduct company to upcycle demolished drywall from a data center into new insulation and acoustic panels. Additionally, Lendlease, a military housing developer, is exploring similar ventures using old asphalt shingles.
The ability of mushrooms to break down waste materials and their potential in creating a circular economy have not gone unnoticed. Audrey Speyer, the founder of PuriFungi, cultivates fungi in a controlled environment, inoculating cigarette butts and hemp with oyster mushroom spores. Through this process, mycelium breaks down toxins in the cigarette butts and grows into a styrofoam-like material that can be molded into various shapes.
The applications of mushrooms in waste management extend beyond pollution remediation and waste upcycling. Mushrooms also demonstrate sustainable solutions through their balanced interchange with the environment, inspiring humans to live more regeneratively and thrive within natural limits.
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Frequently asked questions
Yes, humans are more closely related to mushrooms than to plants. Fungi, including mushrooms, share genetic characteristics with animals that are not found in plants.
Both mushrooms and humans store carbohydrate energy as glycogen, while plants use starch to store energy.
Both humans and mushrooms have developed powerful medicinal properties. Some mushrooms can boost immunity, fight tumours, lower inflammation, and support brain health. Mushrooms can also induce dreamlike states, which can be used to treat mental health issues and facilitate psychological growth.
Mushrooms can break down waste materials through their enzymatic secretions and mycelial networks. This allows mushrooms to restore depleted soils, remediate pollution, break down plastics, and help curb climate change.

























