
Mushrooms are a rich source of nutrients and have been a part of the human diet for thousands of years. While they are known to cause allergic reactions in some people, the relationship between mushrooms and histamine is complex. Histamine is a compound produced by the body's immune system to combat foreign substances, but it also has other functions, such as regulating the sleep-wake cycle and cognitive function. Although mushrooms are generally considered a low-histamine food, some types may contain modest amounts of histamine or histamine-like amines, which can trigger intolerance symptoms in certain individuals. White mushrooms, in particular, are commonly consumed and considered safe for those following a low-histamine diet. However, the impact of mushroom consumption on histamine levels can vary from person to person, and further research is ongoing.
| Characteristics | Values |
|---|---|
| Are white mushrooms high in histamine? | White mushrooms are not high in histamine. They are generally considered a low-histamine food and may be safe to include in a low-histamine diet. |
| Foods high in histamine | Aged cheese, fermented foods, and certain types of fish are known to be high in histamine. |
| Histamine intolerance | Approximately 1% of the population has a histamine intolerance, which is more common in middle age. |
| Symptoms of histamine intolerance | Symptoms of histamine intolerance include headaches, nasal congestion, fatigue, gastrointestinal disturbances, coughing, wheezing, watery eyes, stuffy or runny nose, and low blood pressure. |
| Histamine liberators | Histamine liberators are foods that trigger the release of histamine in the body. Mushrooms are not typically classified as histamine liberators. |
| Role of histamine | Histamine is a compound involved in immune responses and plays a crucial role in proper digestion, wound healing, and nerve signaling. |
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What You'll Learn

Mushrooms are a low-histamine food
Mushrooms have been a part of the human diet for thousands of years for their medicinal properties. They contain a variety of interesting compounds due to their high content of polysaccharides, proteins, vitamins, minerals, trace elements, and antioxidants. The polysaccharides present in mushrooms can influence the intestinal microbiota depending on their structure and their solubility degree. The lion's mane mushroom, for example, has been related to the gut-brain axis connection and neurogenesis.
Some common types of edible mushrooms include shiitake, reishi, cordyceps, cremini, white, button, and portobello mushrooms. While mushrooms are generally low in histamine, they are a source of histamine-like amines like putrescine. This could potentially lead to symptoms in people with histamine intolerance, such as headaches, nasal congestion, fatigue, and gastrointestinal disturbances. It is important to note that individuals with histamine intolerance may react differently to mushrooms, and it is crucial to individualize your diet based on your tolerance.
For those following low-histamine diets due to histamine intolerance, incorporating mushrooms can be a balancing act. Given that mushrooms contain biogenic amines, individuals may react differently depending on their personal tolerance threshold. While mushrooms are not typically classified as histamine liberators (foods that trigger the release of histamine in the body), it is always advisable to work closely with a healthcare provider to determine the amount and type of mushrooms that are suitable for a low-histamine meal plan.
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Histamine intolerance
While nearly all foods contain some histamine, the specific foods to limit or avoid on a low-histamine diet vary from person to person based on their sensitivity. Some foods that are high in histamine include spinach, tomatoes, aged cheeses, processed meat, and beer. Additionally, some fruits, such as strawberries, bananas, pineapple, and citrus fruits, can trigger the release of histamine. It is important to note that histamine intolerance is different from a food allergy, and the prevalence of food allergies is estimated to be much lower than the prevalence of food intolerance.
Mushrooms are generally considered low-histamine foods and can be included in a low-histamine diet. However, while histamine levels in mushrooms vary, studies suggest that a high putrescine content in mushrooms could increase the adverse effects of histamine and lead to histamine intolerance symptoms in some individuals. Therefore, people with histamine intolerance should monitor their responses after consuming mushrooms and work with a healthcare provider to determine the appropriate amount and type of mushrooms to include in their diet.
To identify and manage histamine intolerance, individuals can keep a food diary to track their food intake and symptoms. This can help identify patterns and determine if specific foods are triggering symptoms. Additionally, allergy testing and working with a dietitian can provide further guidance on managing histamine intolerance. It is important to note that there is a lack of consensus on a single diagnostic approach for histamine intolerance, and further research is needed to define, diagnose, and clinically manage this condition effectively.
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Histamine is a compound involved in immune responses
Histamine is a chemical compound produced and released by the immune system as a response to foreign substances, or allergens, that enter the body. It is a type of biogenic vasoactive amine, which causes symptoms such as allergies. Histamine is also associated with inflammatory conditions such as asthma and autoimmune diseases. It is produced by mast cells, which are a type of white blood cell present in connective tissues throughout the body, especially under the skin and near blood and lymph vessels. Basophils, another type of white blood cell, also produce histamine.
Histamine is a signalling chemical that sends messages to various cells within the human body. It is involved in several functions, including the sleep-wake cycle and cognitive function regulation. Histamine intolerance occurs when the body does not break down histamine properly, leading to high histamine levels and bothersome symptoms.
The presence of histamine in foods is an important consideration for individuals with histamine intolerance. While nearly all foods contain some histamine, certain foods are recommended to be limited or avoided on a low-histamine diet. Mushrooms are generally considered low-histamine foods and can be included in a low-histamine diet. However, some individuals with histamine intolerance may experience symptoms after consuming mushrooms due to the presence of histamine-like amines like putrescine.
Histamine plays a crucial role in modulating the immune response and inflammation. It acts as an alarm, triggering inflammatory responses by the immune system. Histamine receptors, such as H4R, play a significant role in this process. The activation of H4R leads to the accumulation of inflammatory cells and the control of cytokine secretion by DC and T cells. Histamine also has regulatory functions in innate and adaptive immune responses, contributing to homeostasis and intestinal regulation.
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Mushrooms are not histamine liberators
Mushrooms are a rich source of nutrients and have been a part of the human diet for thousands of years. They are known to possess medicinal properties, including antiviral, antimicrobial, anti-inflammatory, hypocholesterolemic, and antitumor activities. While mushrooms are associated with histamine intolerance in some individuals, they are not considered high-histamine foods.
Histamine is a compound produced by the body's immune system in response to potential allergens. It plays a crucial role in immune responses, digestion, wound healing, and nerve signaling. However, too much histamine can lead to histamine intolerance, causing symptoms such as itching, sneezing, food intolerance, coughing, wheezing, watery eyes, stuffy or runny nose, headaches, stomach upset, and low blood pressure.
Histamine intolerance affects approximately 1% of the population, and those affected may experience symptoms when consuming foods containing histamine or histamine-like substances. While mushrooms are generally considered a low-histamine food, some types of mushrooms do contain modest amounts of histamine. However, they are not classified as histamine liberators, which are foods that trigger the release of histamine in the body.
The relationship between mushrooms and histamine is complex. While most edible mushrooms are low in histamine, they contain histamine-like amines, such as putrescine and spermidine, which are known to cause symptoms in people with histamine intolerance. However, the presence of these amines does not make mushrooms histamine liberators. The adverse effects of histamine intolerance after consuming mushrooms are likely due to the interaction of these amines with histamine rather than the release of histamine by mushrooms.
Additionally, the variability in responses to mushroom consumption among individuals with histamine intolerance is noteworthy. While some people may experience symptoms, others may tolerate mushrooms well. It is crucial for individuals with histamine intolerance to work closely with healthcare providers to determine their personal tolerance levels and include mushrooms in their diet accordingly.
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Histamine intolerance symptoms
Histamine intolerance occurs when the body cannot break down the histamine present in certain foods, leading to a buildup of histamine and resulting in symptoms such as allergy symptoms, sleep cycle disruption, and cognitive dysfunction. While histamine intolerance is a controversial topic and is not recognized as a condition by the American Academy of Allergy, Asthma & Immunology, it is believed by some scientists to affect up to 1-3% of the population, with middle-aged people being more commonly affected than younger people.
Symptoms of histamine intolerance vary from person to person and can affect multiple organs, making diagnosis challenging. Common symptoms include gastrointestinal issues such as bloating, abdominal discomfort, gas, diarrhea, and constipation. Respiratory symptoms such as rhinorrhea, rhinitis, nasal congestion, dyspnea, and sneezing may also occur. Other symptoms include irregular or racing heartbeat, watery eyes, headaches, flushing, itching, anxiety, and insomnia. Some researchers also believe that histamine intolerance may be linked to attention deficit hyperactivity disorder (ADHD) symptoms, although more research is needed to confirm this.
The presence of diverse, unexpected, and random symptoms, particularly after food consumption, suggests a strong possibility of histamine intolerance. Triggers for histamine intolerance include aged or fermented foods such as wine, beer, sauerkraut, and cheese. Canned, processed, and spoiled foods may also trigger histamine intolerance. Additionally, certain medications, such as blood pressure medicines, antibiotics, prescription painkillers, local anesthetics, and diuretics, can increase histamine levels in the body.
While nearly all foods contain some histamine, individuals with histamine intolerance should focus on limiting or avoiding foods known to be high in histamine or those that trigger their specific symptoms. A low-histamine diet typically includes gluten-free grains, fresh meat that has not been aged, and fresh or flash-frozen salmon. Mushrooms are generally considered low-histamine foods and can be included in a low-histamine diet, although some individuals with histamine intolerance may experience side effects such as headaches, nasal congestion, fatigue, and gastrointestinal disturbances after consuming mushrooms.
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Frequently asked questions
Mushrooms, including white mushrooms, are generally considered to be low-histamine foods. However, some people with histamine intolerance may still experience symptoms after consuming them.
Histamine intolerance occurs when the body cannot break down histamine properly, leading to a build-up that may cause allergy-like symptoms such as coughing, sneezing, itching, and a stuffy or runny nose.
Symptoms of histamine intolerance include headaches, nasal congestion, fatigue, gastrointestinal disturbances, and other allergy-like symptoms.
Yes, foods that are typically high in histamine include aged cheeses, fermented foods, certain types of fish, and some fruits such as strawberries, bananas, and citrus fruits.

























