
Mushrooms are incredible organisms that play a beneficial role in our lives. While they are often associated with rotting food and fungal diseases, they have a positive impact too. One question that often comes up is whether mushrooms contain penicillin. After all, both molds and mushrooms belong to the Fungi kingdom. However, it's important to note that mushrooms and penicillin are chemically and biologically distinct. So, do mushrooms have penicillin? The short answer is no. Mushrooms, including culinary and psychedelic varieties, do not contain penicillin. Penicillin is derived from a specific type of mold known as Penicillium, and only certain species within this genus produce penicillin.
| Characteristics | Values |
|---|---|
| Do mushrooms have penicillin? | No, mushrooms do not contain penicillin. |
| Are mushroom allergies and penicillin allergies related? | In most cases, being allergic to penicillin does not mean you will also be allergic to mushrooms. However, if you have a history of multiple fungal allergies, it is recommended to approach with caution. |
| What is the difference between mushrooms and penicillin? | Mushrooms and penicillin are both fungi, but they are chemically and biologically distinct. Penicillin is derived from a specific type of mold (Penicillium), whereas mushrooms belong to different biological classifications. |
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What You'll Learn
- Penicillin is derived from a specific type of mold, Penicillium
- Mushrooms are fungi, but they do not contain penicillin
- A penicillin allergy doesn't automatically mean you're allergic to mushrooms
- Penicillium griseofulvum is a new penicillin producer found in corn, wheat, barley, flour, and walnuts
- Food allergies are rarely seen in Penicillium-allergic people who eat foods processed with this fungi

Penicillin is derived from a specific type of mold, Penicillium
Penicillin is a group of β-lactam antibiotics derived from the Penicillium mould, primarily the species P. chrysogenum and P. rubens. Scottish bacteriologist Alexander Fleming discovered penicillin in 1928 when he observed that colonies of the bacterium Staphylococcus aureus did not grow in areas of a culture contaminated by the green mould Penicillium notatum. He isolated the mould, grew it in a fluid medium, and found that it produced a substance capable of killing many common bacteria that infect humans.
Penicillin was one of the first antibiotics and is still one of the most widely used today. It can be divided into two classes: naturally occurring penicillins (those formed during mould fermentation) and semisynthetic penicillins (those in which the structure of 6-aminopenicillanic acid, found in all penicillins, is altered). The naturally occurring penicillins, penicillin G (benzylpenicillin) and penicillin V (phenoxymethylpenicillin), are still used clinically. Penicillin G is given intramuscularly or intravenously, while penicillin V is administered orally.
Several other species of Penicillium mould have been found to produce penicillin, including P. griseofulvum, P. nalgiovense, P. dipodomys, and P. flavigenum. These species are closely related and belong to the P. chrysogenum complex of xerophilic penicillia. P. griseofulvum has been isolated from corn, wheat, barley, flour, walnuts, and meat products, and thus may be a source of penicillin in food.
While penicillin has saved countless lives, some strains of bacteria, such as Staphylococcus, have developed resistance to it. These bacteria either produce β-lactamase (also known as penicillinase), which disrupts penicillin's internal structure, or lack cell wall receptors for penicillin, making it harder for the drug to enter their cells. This has led to the development of penicillinase-resistant penicillins (second-generation penicillins). However, these agents are less effective against Staphylococcus and carry a higher risk of liver toxicity.
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Mushrooms are fungi, but they do not contain penicillin
Mushrooms, on the other hand, are a different type of fungi. Culinary and psychedelic mushrooms, including magic mushrooms (psilocybin mushrooms), do not contain penicillin. Magic mushrooms contain psilocybin, a psychoactive compound unrelated to penicillin. While both penicillin and magic mushrooms are technically fungi, they are chemically and biologically distinct.
It is important to note that having a penicillin allergy does not necessarily mean you will also be allergic to mushrooms. "Mushroom allergy" typically refers to respiratory allergies caused by inhaling mushroom spores, rather than allergies to consuming mushrooms. However, allergic reactions to edible mushrooms do exist, such as gastrointestinal distress from consuming shiitake mushrooms.
Additionally, while a mould allergy may rarely lead to a food allergy, such as yeast or mushrooms, it does not mean you will develop an allergy to medications like penicillin. There is no direct link between a mould allergy and a penicillin allergy. However, if you have allergies to multiple types of fungi, including penicillin and certain types of mushrooms, you may have an increased risk of reacting to magic mushrooms.
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A penicillin allergy doesn't automatically mean you're allergic to mushrooms
While penicillin and mushrooms are both fungi, they are chemically and biologically distinct. Penicillin is derived from a specific type of mold called Penicillium, which is different from edible or psychedelic mushrooms. Mushrooms, whether culinary or psychedelic, do not contain penicillin. Thus, a penicillin allergy does not automatically mean you're allergic to mushrooms.
Penicillin is an antibiotic derived from the Penicillium mold, which is a specific species of mold. On the other hand, mushrooms are a group of fungi that can be edible or psychedelic. Psilocybin mushrooms, commonly known as magic mushrooms, contain the psychedelic compound psilocybin, which is unrelated to penicillin.
Although both molds and mushrooms belong to the Fungi kingdom, they produce different compounds. While penicillin is derived from Penicillium mold, mushrooms have various classifications, such as Agaricus bisporus and psilocybin mushrooms. Having an allergy to one type of fungus does not necessarily mean you will be allergic to all types of fungi.
However, it is important to note that having a history of allergies may put you at a higher risk of developing other allergies. While an environmental mold allergy does not cause a penicillin allergy, there is a possibility of cross-reactivity between different allergens. If you have allergies to multiple kinds of fungi, including penicillin, shiitake, and porcini, you may be more likely to have an allergy to something in mushrooms. Therefore, if you have a penicillin allergy and are curious about consuming mushrooms, it is advisable to proceed with caution and consult a medical professional for personalized advice.
In summary, while it is possible to have both a penicillin allergy and a mushroom allergy, they are not directly related. The likelihood of being allergic to mushrooms if your allergy is confined to penicillin is slim. However, if you have multiple fungal allergies, the chances of a reaction to mushrooms may increase.
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Penicillium griseofulvum is a new penicillin producer found in corn, wheat, barley, flour, and walnuts
Mushrooms are fungi, and although we may associate fungi with rotting food and fungal diseases, they can be incredibly beneficial. One such benefit is the discovery of penicillin, which was derived from the fungus Penicillium chrysogenum.
Penicillium griseofulvum is a new penicillin producer. It was found to have a penicillin gene cluster similar to that of Penicillium chrysogenum. P. griseofulvum is frequently isolated from corn, wheat, barley, flour, and walnuts, as well as from meat products. This makes it a potential source of penicillin in food. It is important to note that commonly used cheese starters like P. camemberti and P. roqueforti are not penicillin producers and do not possess the penicillin biosynthetic genes.
P. griseofulvum is added to the list of Penicillium species with the ability to produce penicillin, along with P. chrysogenum, P. nalgiovense, Penicillium dipodomys, and Penicillium flavigenum. These species are closely related and belong to the P. chrysogenum complex of taxonomically related xerophilic penicillia.
The presence of penicillin in food can be harmful as it may lead to allergic reactions and the development of penicillin resistance in human-pathogenic bacteria. However, mycobiota growing on food can also be beneficial, contributing to the ripening and development of specific flavor characteristics.
In addition to penicillin, P. griseofulvum also produces griseofulvin, an antifungal drug used to treat fungal infections of the hair, skin, and nails. Griseofulvin binds to fungal tubulin, impairing microtubule function and leading to mitotic arrest. It has a limited spectrum of activity and is primarily used to treat dermatophytosis.
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Food allergies are rarely seen in Penicillium-allergic people who eat foods processed with this fungi
It is rare for people with a Penicillium allergy to experience food allergy reactions when eating foods processed with this fungi. Penicillium is among the top three most common indoor airborne fungi, and it can be found both indoors and outdoors. It usually grows on surfaces such as drywall, wood, painted materials, and various household items. It is also found in soil, decaying plant debris, compost, grains, and rotting fruit.
Penicillium has been used in the food industry for many years, particularly in the production of cheese and fermented foods. For example, Penicillium roqueforti and Penicillium camemberti are essential in producing blue and soft-ripened cheese. Fungi utilized in the fermentation process can serve as allergens and result in allergic reactions after ingestion. However, in the case of Penicillium, food allergy reactions are very rare.
It is important to note that while penicillin was originally developed from Penicillium mold, having a Penicillium mold allergy does not mean that one is allergic to the antibiotic penicillin. Modern-day penicillin antibiotics are produced synthetically and are not contaminated with mold particles. Additionally, an environmental mold allergy does not typically increase the risk of an allergy to penicillin or lead to fungi-related food allergies.
However, it is possible for people with a mold allergy to experience allergic reactions to certain foods, such as yeast or raw mushrooms, due to a phenomenon called cross-reactivity. Cross-reactivity occurs when similar proteins are shared between certain foods and molds. In the case of Penicillium, food allergy reactions have been very rarely reported in people who consume processed cold meat.
In conclusion, while Penicillium is commonly found in indoor and outdoor environments and is used in food production, it rarely causes food allergy reactions in people with a Penicillium allergy. However, cross-reactivity with other foods, such as yeast or raw mushrooms, may be a concern for those with a mold allergy.
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Frequently asked questions
No, mushrooms do not contain penicillin. Mushrooms are fungi, but they are chemically and biologically distinct from penicillin, which is derived from a specific type of mold (Penicillium).
Yes, it is possible to be allergic to both mushrooms and penicillin. However, having a penicillin allergy does not automatically mean you will be allergic to mushrooms. If your allergy is confined to penicillin, the chances of being allergic to mushrooms are slim.
A "mushroom allergy" typically refers to respiratory allergies caused by inhaling mushroom spores. Allergic reactions to edible mushrooms have also been reported, with symptoms including gastrointestinal distress, rashes, hives, itching, redness, swelling, and, in rare cases, anaphylaxis.

























