Sarah Brown
Naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat opioid and alcohol use disorders. It is not an opioid, is non-addictive, and does not cause withdrawal symptoms. Naltrexone blocks the euphoric and sedative effects of opioids and alcohol by binding to the body's endorphin receptors. While there is limited research on the interaction between naltrexone and psilocybin (the active compound in magic mushrooms), some people have reported that taking naltrexone reduced the effects of magic mushrooms, resulting in a weaker trip. However, there are also reports of individuals taking both naltrexone and magic mushrooms without any noticeable difference in the effects of the mushrooms.
| Characteristics | Values |
|---|---|
| Naltrexone use | Used to treat opioid and alcohol use disorder, blocks the euphoric and sedative effects of opioids and reduces alcohol cravings |
| Side effects | Nausea, vomiting, dizziness, drowsiness, decreased alertness, abnormal behaviour, suicidal thoughts, liver damage, hepatitis, and more |
| Precautions | Not recommended for those under 18, pregnant or breastfeeding women, or those with liver disease; may cause increased sensitivity to opioids and should not be combined with alcohol, sedatives, or tranquilizers |
| Mushroom use | Used for recreational and medicinal purposes, with the potential to cause "bad trips" characterized by anxiety and paranoia |
| Naltrexone and mushroom interaction | Anecdotal evidence suggests naltrexone may dull the effects of mushrooms, but there is limited research available |
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What You'll Learn
- Naltrexone and magic mushrooms together may cause dizziness, diarrhoea, and a low heart rate
- Naltrexone may dull the effects of mushrooms, but there is no research to support this
- Naltrexone is used to treat alcoholism and opioid use disorder
- Magic mushrooms are often used to treat chronic pain
- Mushrooms are dangerous when taken with other substances
Naltrexone and magic mushrooms together may cause dizziness, diarrhoea, and a low heart rate
Naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) and alcohol use disorder (AUD). It is not an opioid, is non-addictive, and does not cause withdrawal symptoms when its use is stopped. Naltrexone blocks the euphoric and sedative effects of opioids and alcohol by binding to and blocking opioid receptors, reducing cravings, and suppressing the rewarding feelings associated with these substances.
Magic mushrooms, on the other hand, are hallucinogenic substances that contain psilocybin, a naturally occurring psychedelic compound. Psilocybin primarily affects serotonin receptors and has a low risk of toxicity. It is often used for its therapeutic potential in treating conditions like alcohol use disorder and has the lowest risk profile of any recreational drug when used alone.
Combining naltrexone and magic mushrooms may lead to adverse effects. Naltrexone has been reported to potentially dull the effects of magic mushrooms, resulting in weaker experiences compared to when mushrooms are consumed alone. Additionally, some individuals have reported experiencing side effects such as dizziness, diarrhoea, and a low heart rate when taking both substances.
It is important to note that limited research has been conducted on the interaction between naltrexone and magic mushrooms. The available information is primarily based on anecdotal evidence and personal reports. The specific effects may vary depending on dosage, timing, and individual differences.
As with any substance use, it is essential to exercise caution and seek medical advice before combining substances, especially when dealing with prescription medications like naltrexone. The potential risks and benefits should be carefully considered, and individuals should be mindful of their unique health circumstances and any contraindications.
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Naltrexone may dull the effects of mushrooms, but there is no research to support this
Naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat opioid and alcohol use disorders. It works by blocking the euphoric and rewarding feelings associated with opioid drugs and alcohol, reducing cravings, and helping individuals maintain sobriety. While naltrexone is not an opioid itself, some people have expressed concerns about its potential interaction with magic mushrooms, which are known to have psychoactive effects.
There are a few anecdotal reports suggesting that naltrexone may indeed dull or stop the effects of magic mushrooms. For example, one individual on a Reddit forum reported that their usual dose of mushrooms felt "pathetically weak" while they were on naltrexone for alcoholism. They speculated that naltrexone might have affected their mushroom experience, leading them to consider discontinuing naltrexone before their next mushroom trip. Another person on the same forum expressed concern that naltrexone could "cancel out" the benefits they experience from using magic mushrooms to manage their chronic pain and other health issues.
However, it is important to note that there is currently no scientific research or clinical studies specifically examining the interaction between naltrexone and magic mushrooms. The existing evidence is limited to personal accounts and speculative theories shared on online forums. As one individual on a Reddit forum correctly pointed out, doctors cannot provide official advice on illegal substances like magic mushrooms, and there is simply no scientific data available on this topic.
Additionally, it is worth considering the complex nature of substance interactions. Magic mushrooms primarily affect serotonin receptors but also indirectly influence other receptors and neurotransmitters, including dopamine levels. Naltrexone, on the other hand, is known to act on opioid receptors. The lack of research makes it challenging to determine whether and how these two substances might interact.
In conclusion, while there are some anecdotal reports suggesting that naltrexone may dull the effects of magic mushrooms, there is currently no scientific research to support or refute this claim. Individuals considering the concurrent use of naltrexone and magic mushrooms should proceed with caution and consult with healthcare professionals whenever possible, as the lack of research highlights the potential risks and unknown variables associated with this combination.
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Naltrexone is used to treat alcoholism and opioid use disorder
Naltrexone is an FDA-approved opioid antagonist used to treat alcohol use disorder and opioid dependence. It is available in pill form for AUD and as an extended-release intramuscular injectable for AUD and OUD. The pill form is taken daily, while the injectable formulation is administered once a month. Naltrexone is also available as an oral tablet with a usual dose of 50mg for alcohol treatment ranging from 50 to 100mg.
Naltrexone blocks the euphoric and rewarding feelings associated with opioid use, including heroin. It is important to note that patients taking naltrexone should not consume opioids, alcohol, or other drugs, as it may lead to serious health consequences. Naltrexone is intended to be used as part of a comprehensive treatment plan, including counselling and other behavioural health therapies.
Naltrexone has been found to reduce cravings for alcohol and decrease alcohol consumption. It is important to consult with a healthcare provider before initiating treatment with naltrexone, as it may not be suitable for individuals with certain medical conditions, such as liver or kidney problems, and can cause side effects such as dizziness, drowsiness, and abnormal behaviours.
While there is limited information on the interaction between naltrexone and magic mushrooms, some individuals have reported that the effects of mushrooms were diminished when taken with naltrexone. However, there is a lack of research in this area, and further studies are needed to understand the full extent of any potential interaction.
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Magic mushrooms are often used to treat chronic pain
Magic Mushrooms for Chronic Pain Treatment
Magic mushrooms, or psilocybin, are under investigation as a potential treatment for chronic pain. Chronic pain can be neuropathic, inflammatory, or nociplastic, and current treatments often fail to meet patient needs. Psilocybin has been shown to produce sustained benefits when used in conjunction with psychotherapy for conditions like refractory depression, end-of-life anxiety, and addiction.
In a proof-of-concept study, psilocybin was found to provide significant relief from chronic pain in a patient with phantom limb syndrome, a type of neuropathic pain. This patient had not found adequate relief from opioids or mirror visual feedback therapy alone, but psilocybin offered notable, albeit temporary, relief.
Initial studies in animal models of neuropathic and inflammatory pain have been conducted, and further research is needed to fully understand psilocybin's potential as an anti-nociceptive agent. The mechanism of action is thought to involve targeting serotonergic pathways and improving functional connectivity in brain regions involved in chronic pain.
Some individuals have reported using magic mushrooms to manage their chronic pain conditions, such as neuropathy and fibromyalgia, with positive results. However, there is limited clinical evidence at present regarding the utility of psilocybin in chronic pain treatment, and more research is needed.
It is important to note that the use of magic mushrooms for any purpose, including chronic pain management, should be done under the guidance of a healthcare professional, as there are potential risks and side effects associated with their consumption.
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Mushrooms are dangerous when taken with other substances
Magic mushrooms are significantly more dangerous when taken alongside other substances, both illicit and prescribed. This includes other hallucinogens and antidepressants, as the combination could lead to serotonin syndrome, which can be fatal. Psilocybin, the psychedelic compound found in magic mushrooms, also interacts with other psychedelics.
Some people take benzodiazepines like Valium to prevent bad trips when taking psilocybin and other hallucinogens. However, the CNS depressant effects of benzodiazepines could, when combined with the perceptual distortion of psilocybin, lead to accidents and injuries. It may also be difficult to get the dosage right, and people on psilocybin are at risk of accidentally taking excessive doses of benzodiazepines, which could lead to respiratory depression, coma, and death.
Psilocybin and marijuana are also a common combination. One study found that nearly 60% of university students who had recently taken magic mushrooms consumed cannabis at the same time. Anecdotal evidence suggests that cannabis can be used to manage the nausea and anxiety that magic mushrooms may cause, or simply because some people are daily cannabis users. However, cannabis can also intensify the effects of psilocybin, especially the visual and auditory hallucinations, and this intensity might be overwhelming and frightening for psychedelic novices. This is also the case for those who consume psilocybin edibles alongside THC edibles.
Stimulants such as cocaine, amphetamines, and MDMA increase blood pressure and heart rate, and combining these with psilocybin can cause potentially dangerous hypertension and tachycardia.
There is also a risk when combining psilocybin with alcohol. According to some reports, psilocybin may reduce the perceived effects of alcohol, leading the individual to drink too much. Alcohol and mushrooms that contain psilocybin can both cause nausea and vomiting, and combining the two, especially in high quantities, can make you feel very sick. You may also experience disorientation and confusion and become dehydrated. Large amounts of alcohol can cause a loss of coordination and lower inhibitions.
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Frequently asked questions
Naltrexone is known to block the euphoric and sedative effects of opioids and alcohol. While there is limited research on the interaction between naltrexone and magic mushrooms, some anecdotal evidence suggests that naltrexone may reduce the effects of mushrooms.
Mixing naltrexone and mushrooms may lead to unwanted side effects, including dizziness, diarrhea, and a low heart rate. Additionally, as mushrooms primarily affect serotonin receptors, combining them with naltrexone may result in unintended interactions with other neurotransmitters.
There is a lack of definitive research on the safety of taking naltrexone and mushrooms simultaneously. It is recommended to consult a healthcare professional before mixing any substances, especially when dealing with prescription medications.
Some individuals may consider combining naltrexone and mushrooms to manage specific health conditions. For example, naltrexone is sometimes used to treat autoimmune diseases, while mushrooms have been anecdotally reported to relieve chronic pain.
Psilocybin (the active compound in magic mushrooms) is commonly mixed with marijuana or cannabis. According to a study, nearly 60% of university students who consumed magic mushrooms also used cannabis simultaneously. However, it is important to note that combining substances can significantly increase risks and should be done with caution.
