
LSD (lysergic acid diethylamide) and psilocybin mushrooms, commonly referred to as shrooms, are two of the most widely used hallucinogenic substances. Both are psychedelic drugs that have been used recreationally and in spiritual or therapeutic contexts. While there are some similarities in the effects they produce, such as altered states of reality, time distortion, and changes in perception, mood, and cognition, they differ significantly in chemical composition, physiological effects, and subjective experiences.
| Characteristics | Values |
|---|---|
| Hallucinogenic effects | Both LSD and magic mushrooms are known to induce hallucinations and alter perception, mood, and cognitive processes. |
| History of use | Both substances have been used for centuries in spiritual or shamanic contexts. |
| Health risks | While both are considered to have few major risks, they can cause psychological complications such as paranoia, fear, and anxiety. There is also a risk of developing hallucinogen-persisting perception disorder (HPPD), which can cause recurring hallucinations or "flashbacks." |
| Dependency | Physical tolerance and psychological dependence can develop with both substances. |
| Duration | LSD typically has a longer duration, with trips lasting 8-12 hours compared to 4-6 hours for mushroom trips. |
| Form | LSD is a synthetic, man-made chemical compound, while magic mushrooms are naturally occurring and derived from certain species of fungi. |
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What You'll Learn

Both substances are classified as psychedelics
The two substances are also similar in that they affect the brain's serotonin system, interacting with serotonin receptors and altering mood, perception, and cognition. They have a long history of use in spiritual or shamanic contexts, with indigenous cultures, particularly in Central and South America, having used psilocybin mushrooms for centuries in ceremonial settings to achieve altered states of consciousness for healing, divination, and religious purposes. LSD, although more modern, gained cultural significance during the 1960s counterculture movement.
Despite their similarities, LSD and psilocybin mushrooms differ significantly in terms of chemical composition, physiological effects, and subjective experiences. While both substances can produce "trips", these experiences differ due to factors like onset time, duration, dosage, and frequency of use. Mushrooms tend to produce a more whole-body experience, while LSD trips are largely cerebral. As a result, the concepts of "set" and "setting" are even more essential to an LSD experience, as the environment within which the use occurs can greatly determine how safe the user is during a trip.
In terms of duration, LSD trips can last eight to twelve hours, while mushroom trips typically last four to six hours. The longer duration of LSD trips can result in more intense cerebral experiences, often involving deep thought patterns and vivid visual hallucinations. It is worth noting that the time frame can vary a lot from person to person.
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They are two of the most widely used hallucinogenic substances
LSD (lysergic acid diethylamide) and psilocybin mushrooms, commonly referred to as "shrooms", are two of the most widely used hallucinogenic substances. They are both powerful psychedelics that have been used for centuries in spiritual or shamanic contexts. However, they differ significantly in terms of chemical composition, physiological effects, and subjective experiences.
LSD is a synthetic substance derived from a fungus that grows on rye, while psilocybin mushrooms are naturally occurring fungi that contain the psychoactive compounds psilocybin and psilocin. These chemical differences influence how each substance affects the brain and produces its psychedelic effects. LSD is a man-made chemical compound known for its hallucinogenic and mind-altering effects. It is often consumed in small doses, typically on blotter paper, and has less natural properties than psilocybin mushrooms.
On the other hand, psilocybin mushrooms are naturally grown and known to provide a calming high and spiritual experience. They are typically dried and eaten raw or brewed into tea. Mushrooms have been used for centuries in religious and spiritual practices due to their ability to induce altered states of consciousness. While LSD and psilocybin mushrooms share similarities in inducing altered states of reality, their experiences differ due to factors like onset time, duration of effects, dosage, and frequency of use.
Both substances can create a sense of time distortion and affect the brain's serotonin system, altering mood, perception, and cognition. They can also lead to psychological dependency and long-term health risks, including behavioural issues such as psychosis, anxiety, and impaired judgment. While physical tolerance and dependence can develop with the use of either substance, LSD is more potent than psilocybin mushrooms, making it easier to ingest more than intended. This, combined with the longer duration of effects, may explain why there are generally more reports of "bad" trips with LSD.
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They can cause psychological dependency and long-term health risks
While LSD and magic mushrooms are two of the most widely used hallucinogenic substances, they can lead to psychological dependency and long-term health risks.
LSD is a synthetic chemical compound, whereas magic mushrooms are naturally occurring fungi. Both substances are known to induce altered states of reality, but their subjective experiences differ. An LSD trip occurs mostly in the cerebral region of the brain, while mushrooms tend to produce a whole-body experience. The longer duration of LSD trips can result in more intense cerebral experiences, often involving deep thought patterns and vivid visual hallucinations. On the other hand, a mushroom trip usually comes to a close within 6 hours.
Despite the differences in their experiences, both substances can cause psychological dependency. Users may develop a belief that they need to abuse psychedelics to experience spiritual experiences, causing them to routinely abuse the drugs in large amounts. Additionally, the longer one abuses LSD or mushrooms, the higher the risk of developing adverse side effects.
There are also long-term health risks associated with the use of LSD and magic mushrooms. Chronic users of either substance could develop hallucinogen-persisting perception disorder (HPPD), which causes recurring hallucinations or "flashbacks" weeks, months, or even years after a psychedelic experience. While HPPD is rare, individuals with underlying mental illnesses are more likely to experience it. Additionally, individuals with a history of mental health disorders, especially conditions like schizophrenia, bipolar disorder, or severe anxiety, should refrain from using these substances as they can exacerbate symptoms or trigger underlying issues.
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They have been used for centuries in spiritual and therapeutic contexts
LSD (lysergic acid diethylamide) and psilocybin mushrooms, commonly referred to as "shrooms", are two of the most widely used hallucinogenic substances. They have been used for centuries in spiritual and therapeutic contexts.
Indigenous cultures, particularly in Central and South America, have used psilocybin mushrooms for centuries in ceremonial settings to achieve altered states of consciousness for healing, divination, and religious purposes. Terence McKenna documented the worldwide practices of psilocybin mushroom usage as part of a cultural ethos relating to the Earth and mysteries of nature. He suggested that mushrooms enhanced self-awareness and a sense of contact with a "Transcendent Other", reflecting a deeper understanding of our connectedness with nature.
In the 1960s, LSD gained cultural significance during the counterculture movement. Timothy Leary and Richard Alpert, two of the most famous psychedelic researchers of the time, went from teaching at Harvard to acting as spiritual leaders. The lines between their psychological research and mysticism were blurry. Leary described his operation at the Millbrook estate as "an unpopular religious and social movement, much like the Mormons." Alpert, who later changed his name to Ram Dass, travelled to India in 1967, where he studied Eastern spirituality. He published his bestselling book, *Be Here Now*, about his spiritual quest in 1971.
In recent years, preliminary studies have suggested that psychedelic drugs like LSD and psilocybin mushrooms have potential in treating conditions like PTSD, addiction, and even the fear of death. In 2020, Oregon voters passed Measure 109, which allows for the adult use of psychedelic mushrooms within therapeutic settings.
While both LSD and psilocybin mushrooms have been used in spiritual and therapeutic contexts, they differ in their chemical composition, physiological effects, and subjective experiences. Understanding these differences can offer valuable insights into how each substance interacts with the brain and shapes user experiences.
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They can induce altered states of consciousness
LSD (lysergic acid diethylamide) and psilocybin mushrooms, commonly referred to as "shrooms", are two of the most widely used hallucinogenic substances. Both are psychedelic drugs that can induce altered states of consciousness, often accompanied by visual or auditory hallucinations, profound shifts in sensory perception, and changes in thought processes.
LSD is a synthetic chemical compound derived from a fungus that grows on rye and other grains. It was first synthesized in a laboratory by Swiss chemist Albert Hoffman in 1938. LSD is typically consumed in small doses, often on blotter paper, and has a longer duration of effects compared to psilocybin mushrooms. An LSD trip can last between eight to twelve hours and is largely cerebral, involving deep thought patterns and vivid visual hallucinations. The ever-important concepts of "set" and "setting" are crucial to the LSD experience, as the outcome of the trip can depend on the mindset of the user and the environment in which the use occurs.
On the other hand, psilocybin mushrooms are naturally occurring hallucinogenic substances. They are produced by certain species of mushrooms, most commonly Psilocybe cubensis. Mushrooms are typically dried and eaten raw or brewed into tea. A mushroom trip usually lasts between four to six hours and tends to produce a whole-body experience. Similar to LSD, psilocybin mushrooms can also induce altered states of consciousness, with visual and sensory distortions, changes in mood, and altered thoughts.
Both LSD and psilocybin mushrooms have a long history of use in spiritual or shamanic contexts. Indigenous cultures, particularly in Central and South America, have used psilocybin mushrooms for centuries in ceremonial settings to achieve altered states of consciousness for healing, divination, and religious purposes. LSD, although more modern, gained cultural significance during the 1960s counterculture movement.
While LSD and psilocybin mushrooms can induce similar altered states of consciousness, it is important to note that they differ significantly in their chemical composition, physiological effects, and subjective experiences. These differences can provide valuable insights into how each substance interacts with the brain and shapes user experiences.
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Frequently asked questions
Both LSD and mushrooms are psychedelic drugs that can induce altered states of consciousness, along with visual and auditory hallucinations. They have a long history of use in spiritual or shamanic contexts, particularly in Central and South American indigenous cultures. They can also create a sense of time distortion and affect the brain's serotonin system.
While both substances can produce similar side effects, the experiences they induce differ due to factors like onset time, duration, dosage, and frequency of use. An LSD trip occurs mostly in the cerebral region of the brain, whereas mushrooms tend to produce a whole-body experience. As a result, the "set" and "setting" are even more critical in an LSD experience.
Mushrooms are typically dried and eaten raw or brewed into tea, while LSD is a liquid chemical commonly dropped onto small squares of paper or straight into the mouth. Due to its high potency, LSD is often mixed with other substances and found in various forms, including capsules, tablets, and liquid droppers.
Both substances can lead to psychological dependency and long-term health risks, including behavioral issues such as psychosis, anxiety, and impaired judgment. There is also a risk of unpleasant trips involving paranoia, fear, or frightening hallucinations. Additionally, they can cause physical and psychological complications, especially for individuals with cardiac or vascular disorders.
Effective treatment options for dependency on either substance include drug detoxification, group therapy, and holistic practices. Understanding the differences between LSD and mushrooms can provide valuable insights into their effects on the brain and how they shape user experiences.

























