Microdosing Magic Mushrooms: How Many Milligrams?

The magic in magic mushrooms comes from psilocybin, a naturally occurring alkaloid found in some mushroom species. The amount of psilocybin in dried mushrooms varies between species, ranging from 0.1% to 2% of dry weight. Generally, a low dose of magic mushrooms is considered to be 1 gram, which is likely to induce euphoria and an enhancement of the senses. A medium dose is considered to be between 2.5 and 3.5 grams, which will induce a full-blown psychedelic experience. A high dose, or heroic dose, is considered to be over 5 grams, which may cause a complete loss of the sense of self, also known as ego dissolution or ego death. Microdoses of psilocybin, which do not induce mind-altering effects, typically range from 100 to 300 milligrams of dried magic mushrooms.

Microdosing: 100-250mg of dried mushrooms, no psychedelic effects

Microdosing involves taking small amounts of psilocybin-containing mushrooms that are not enough to cause mind-altering effects. However, some subtle effects like a boost in mood or energy may be felt. The typical microdose range is between 100 mg to 250 mg of dried mushrooms, or 5-10% of a standard dose. This range is considered a safe zone where one is unlikely to experience any psychedelic effects.

It is important to note that the amount of psilocybin in dried mushrooms can vary significantly between species, ranging from 0.1% to 2% of dry weight. The average psilocybin content is around 1% or 10 mg per gram of dried mushrooms. Therefore, an eighth-ounce or 3.5 grams of dried mushrooms will typically contain around 35 mg of psilocybin, which is considered a high dose and will likely induce a full-blown psychedelic experience.

To ensure safety and avoid unintended negative consequences, it is recommended to start with a low dose of no more than one gram of dried mushrooms or 10 mg of psilocybin. This dose may produce noticeable effects, but they are unlikely to be full-blown psychedelic experiences. If you consume half of an eighth-ounce (1.75 grams), you may experience some psychedelic effects, including visuals and a heavier euphoria.

It is worth mentioning that microdosing protocols typically involve consuming these small doses across designated dosing days and days off. The two most common protocols are the Stamets Protocol (5 days of microdosing followed by 2 days off) and the Fadiman Protocol (1 day of microdosing followed by 2 days off). These protocols allow for the safe exploration of the potential benefits of microdosing while minimizing the risk of adverse effects.

Low dose: 10mg of psilocybin, no psychedelic effects

Psilocybin, the psychoactive substance in magic mushrooms, is illegal in many places. However, it has been used in controlled settings to treat mental health conditions, including treatment-resistant depression (TRD) and PTSD.

When consumed, psilocybin can cause a range of psychological, perceptual, and physical effects. At low doses, psilocybin can induce euphoria and an enhancement of the senses, such as seeing more vibrant colours. This is typically achieved with a dose of 1 gram of dried mushrooms, which, at 1% psilocybin content, would contain 10 milligrams (mg) of psilocybin. It is important to note that this dose is not considered a microdose, but it is still a low, noticeable dose that will not produce full-blown psychedelic effects.

In a study conducted by King's College London, psilocybin was safely administered to healthy participants at doses of 10 mg or 25 mg. The participants were closely monitored for six to eight hours following administration and then followed up for 12 weeks. During this time, no short- or long-term detrimental effects were observed, and there were no instances of anyone withdrawing from the study due to adverse events.

While low doses of psilocybin may not produce full-blown psychedelic effects, it is important to note that psilocybin use still carries risks. Accidental poisoning can occur if poisonous mushrooms are consumed by mistake, and regular use may lead to tolerance and cross-tolerance with other drugs. Additionally, psilocybin may cause adverse reactions such as nausea, panic attacks, disturbing hallucinations, anxiety, and panic. Therefore, it is crucial to exercise caution and seek information from reliable sources before consuming psilocybin.

Medium dose: 20-30mg of psilocybin, psychedelic effects

A medium dose of psilocybin, typically ranging from 20 to 30 mg, can induce a range of psychedelic effects. This dosage falls within the therapeutic range of 20 to 30 mg/70 kg, as observed in several studies. It is important to note that the effects of psilocybin can vary between individuals, and body weight can play a role in the overall impact. While some people may experience a "full-blown psychedelic experience", others may have more subtle yet noticeable effects.

At this dosage, individuals may encounter perceptual and cognitive distortions, including open- and closed-eye visuals, synesthesia, and heightened euphoria. The intensity of these effects can vary, with some users reporting life-changing experiences comparable to significant life events such as the birth of a first child. It is crucial to approach this dosage range with caution and a mindful attitude, as the potential for a profound impact on one's life cannot be understated.

The effects of a medium dose of psilocybin can be highly variable, and individual sensitivity, setting, and mindset also play a role in the overall experience. Some people may find that a medium dose provides a balance between the subtle effects of a low dose and the more intense effects of a high dose. It is always recommended to start with lower doses and gradually increase the amount to manage the intensity of the experience and reduce potential risks.

While psilocybin has shown promising results in controlled therapeutic settings, it is important to remember that it is a controlled substance in many places. The legality of psilocybin varies by region, and it is essential to be aware of the local laws and regulations before considering its use. Additionally, it is always advisable to seek professional guidance and supervision when exploring the use of psilocybin or other psychoactive substances.

High dose: 30mg+ of psilocybin, full-blown psychedelic experience

When ingesting psilocybin mushrooms, the dosage will determine the intensity and nature of the experience. A high dose is generally considered to be 30 mg or more of psilocybin, the primary psychoactive compound found in magic mushrooms. At this dosage, individuals can expect a full-blown psychedelic experience, with intense visual and auditory hallucinations, distorted perception of time and space, and profound alterations in consciousness.

The effects of a high dose of psilocybin mushrooms can be intense and unpredictable. Users may experience a loss of sense of self, ego dissolution, and a complete detachment from reality. Visual hallucinations can be vivid and intricate, with geometric patterns, bright colors, and morphing shapes. Some users report experiencing synesthesia, where the senses blend, causing them to "see" sounds and "hear" colors, for example. Time perception is often distorted, with moments feeling stretched out or condensed.

It is important to approach a high dose with caution and respect for the power of the substance. The experience can be life-altering and revealing, but it also carries potential risks. Individuals with a personal or family history of mental health issues, such as schizophrenia or bipolar disorder, should approach with extreme caution, as psychedelics can exacerbate underlying conditions. Always source mushrooms from a trusted supplier, and be aware of the potential for adverse reactions or a "bad trip."

It is recommended to have a sober trip sitter present when taking a high dose, especially for first-time users or those with limited experience. A trip sitter can provide guidance, reassurance, and support during the journey, helping to ensure a safe and positive experience. They can also assist with harm reduction measures, such as preventing accidental injury and ensuring access to water and comfortable surroundings.

When ingesting a high dose of psilocybin mushrooms, it is advisable to create a comfortable and safe setting beforehand. This may include preparing a quiet and familiar space, arranging comfortable seating or a bed, and having access to water and any desired comforts, such as music or a cozy blanket. Ensuring privacy and limiting external distractions can also enhance the experience.

A high dose of psilocybin mushrooms can be a profound and transformative experience, offering a complete immersion in the psychedelic realm. It can facilitate deep introspection, reveal hidden insights, and induce a sense of connection to something greater than oneself. However, it is important to approach this dosage with preparation, respect, and a sense of responsibility to ensure a positive and safe journey.

Toxicity: fatalities due to psilocybin toxicity are rare

Psilocybin is a hallucinogenic chemical found in certain mushrooms, often referred to as "magic mushrooms". The effects of consuming psilocybin mushrooms range from euphoria to hallucinations, with the specific effects depending on the quantity of the drug consumed, the individual's past experiences, and their expectations of the experience. Typically, a dose of 1 gram of magic mushrooms is considered a low dose, while a common quantity is an eighth of an ounce, or 3.5 grams, which will likely lead to a full-blown psychedelic experience.

While fatalities due to psilocybin toxicity are rare, there are still risks associated with consuming magic mushrooms. Psilocybin has sympathomimetic and cardiovascular effects, such as increased heart rate and blood pressure, which are usually mild but can be a risk factor for users with pre-existing hypertension. Psilocybin can also cause nausea and vomiting, pupil dilation, changes in stretch reflex, tremors, and dysmetria. Furthermore, there is a potential risk of cardiac fibrosis and valvulopathy with frequent and repeated use of psilocybin. However, single high doses or widely spaced doses are thought to be safe, and hospitalizations from psilocybin use are uncommon.

One of the main risks associated with magic mushrooms is the potential for accidental ingestion of more toxic mushrooms. Some species of mushrooms, such as those from the genus Cortinarius, are nephrotoxic and can lead to serious and permanent organ dysfunction or even fatalities. This is particularly dangerous as magic mushrooms can be mistaken for other, more toxic, varieties. Therefore, it is crucial to accurately identify mushrooms before consumption to avoid toxic effects.

Additionally, the effects of psilocybin can be unpredictable, and disturbing hallucinations, anxiety, and panic attacks may occur. In some cases, ingestion of magic mushrooms has resulted in "horror trips" combined with self-destructive and suicidal behaviour, especially in individuals with mental or psychiatric disorders. Furthermore, while rare, severe outcomes such as psychosis or organ damage may occur due to hallucinogenic mushroom poisoning. Therefore, while fatalities from psilocybin toxicity are uncommon, it is important to approach the consumption of magic mushrooms with caution and be aware of the potential risks involved.

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