
Mushrooms have been used for thousands of years as a food source and for their medicinal properties. They are a good source of carbohydrates, proteins, amino acids, vitamins, and minerals. They are also rich in anti-inflammatory components, such as polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules. Modern research confirms the therapeutic effects of edible mushrooms, showing that they can help to reduce inflammation and improve the efficiency of the immune system.
| Characteristics | Values |
|---|---|
| Medicinal use | Anti-inflammatory, anti-cancer, antioxidant, antimicrobial, antihyperlipidemic, antitumor, analgesic, antimicrobial, antihyperlipidemic, hepatoprotective, hypoglycemic, hypolipidemic |
| Nutritional value | Carbohydrates, proteins, amino acids, minerals, vitamins, polyunsaturated fatty acids |
| Species with anti-inflammatory properties | Panaeolus cyanescens, Psilocybe natalensis, Psilocybe cubensis, Psilocybe cubensis leucistic A+ strain, Agaricus bisporus, Lentinus edodes, Lentinus polychrous, Termitomyces albuminosus, Phellinus linteus, Pleurotus ostreatus, Termitomyces (Uganda), G. lucidum (Japan) |
| Other | Mushrooms are referred to as a "superfood" and are recommended as a valuable constituent of the daily diet |
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What You'll Learn
- Mushrooms have been used for their nutritional and medicinal value for thousands of years
- Mushrooms contain anti-inflammatory components such as polysaccharides, phenolic compounds, and fatty acids
- Prolonged inflammation can cause inflammatory diseases such as arthritis, inflammatory bowel disease, and multiple sclerosis
- Magic mushrooms have been used since ancient times for their mind-healing properties
- Mushrooms are a natural way to treat chronic pain and may help retrain the brain away from it

Mushrooms have been used for their nutritional and medicinal value for thousands of years
The medicinal effects of mushrooms include anti-inflammatory, antioxidant, anticancer, antidiabetic, and immunomodulatory properties. Modern research confirms the therapeutic effects of traditionally used species. Mushrooms are rich in anti-inflammatory components, such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins, and biometals. For example, the aqueous extract of fucogalactan from Agaricus bisporus, one of the most cultivated mushrooms, exhibited an anti-inflammatory response in male Swiss mice.
Edible mushrooms like maitake and shiitake have been used as medicine throughout history. Other mushrooms that are too tough to eat, such as reishi, have also been used solely for medicinal purposes. Plant chemicals and components in mushrooms may exert antioxidant, anti-inflammatory, and anticancer effects, although the exact mechanism is still unclear and an area of active research. Cell and animal studies show that mushrooms can stimulate the activity of immune cells, macrophages, and free radicals that can stop the growth and spread of tumor cells and cause existing tumor cells to die.
Mushrooms are also recognised by chefs for their ability to create savoury rich flavours called umami, thanks to the presence of the amino acid glutamate. They are considered a delicacy with high nutritional and functional value and are also accepted as nutraceutical foods. They have a beneficial effect on the organism through the improvement of its overall health and nutritional level.
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Mushrooms contain anti-inflammatory components such as polysaccharides, phenolic compounds, and fatty acids
Mushrooms have been used for their nutritional and medicinal value for thousands of years. They are a good source of carbohydrates, proteins, amino acids, and minerals. They are also rich in anti-inflammatory components, such as polysaccharides, phenolic compounds, and fatty acids.
Polysaccharides, a type of carbohydrate, are known to possess anti-inflammatory and immunomodulating properties. For example, lentinan, a polysaccharide found in shiitake mushrooms, has been shown to have intestinal anti-inflammatory effects in a dextran sulfate sodium (DSS)-induced colitis mice model. It also suppressed inflammation by inhibiting the production of TNF-α and IL-8 through the activation of nuclear factor-kappa-B (NF-κB).
Phenolic compounds are another group of anti-inflammatory metabolites found in mushrooms. Grifolin and neogrifolins, for instance, are farnesyl phenolic compounds isolated from the edible mushroom Albatrellus ovinus that exhibit anti-inflammatory properties. Additionally, the fruiting bodies of the ectomycorrhizal edible truffle Elaphomyces granulatus contain two active aromatic compounds with anti-inflammatory activities: syringaldehyde and syringic acid.
Fatty acids, such as polyunsaturated fatty acids (PUFAs), are also present in mushrooms. PUFAs are beneficial for health as they are precursors of eicosanoids, which are signalling molecules necessary for the proper regulation of cellular processes in muscles, blood vessels, nerve cells, and the immune system. The fatty acids in mushrooms support anti-inflammatory processes in the human body due to their high content of unsaturated fatty acids.
In summary, mushrooms contain a diverse range of anti-inflammatory components, including polysaccharides, phenolic compounds, and fatty acids, which contribute to their therapeutic and health-promoting benefits.
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Prolonged inflammation can cause inflammatory diseases such as arthritis, inflammatory bowel disease, and multiple sclerosis
Inflammation is a natural response of the immune system to damaging factors, such as physical, chemical, or pathogenic trauma. It is a complex set of interactions among soluble factors and cells that can arise in any tissue. Injuries and infections typically cause acute inflammation, while environmental factors, including aspects of daily life and exposure to toxins, are the culprits behind most cases of chronic inflammation. Chronic inflammation can last for months or years, with periods of improvement and deterioration. It occurs when the body continues to send inflammatory cells even when there is no danger, and can lead to severe damage in affected areas.
Prolonged inflammation can cause inflammatory diseases, which account for over half of all deaths globally. Familiar inflammatory diseases include rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease (IBD), and multiple sclerosis. These diseases can affect almost any organ in the body, and in most cases, more than one organ or organ system. Symptoms include joint stiffness, pain, loss of function, and rashes, with periods of remission and flare-ups.
Inflammatory bowel disease usually appears as a sudden flare-up of symptoms, typically affecting people aged 35 or younger, with a second peak of diagnosis in the 60s. IBD causes a range of problems in the colon and rectum but can also affect other parts of the body. It can run in families, but it can also develop randomly without a family history. About half of people with IBD may need surgery to remove areas of the intestine damaged by prolonged inflammation. While diet cannot reverse IBD, modifications can help reduce symptoms. For example, omega-3 fatty acids can ease inflammation, while diets high in omega 6, such as red meats and fried foods, can aggravate symptoms.
Arthritis is another inflammatory disease that can affect the joints in various parts of the body, including the limbs, spine, and blood circulation. For example, sacroiliitis is the inflammation of the joints connecting the lower spine with the pelvis. Juvenile idiopathic arthritis (JIA) and rheumatoid arthritis are also linked to chronic inflammation. Treatments for inflammatory diseases include immunosuppressants and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin, and naproxen.
Mushrooms have been used extensively for thousands of years due to their nutritional and medicinal value. They are a potential natural source of anti-inflammatory compounds and are considered a “superfood” with therapeutic effects. Modern research confirms the therapeutic effects of traditionally used species, and edible mushrooms are recommended as a valuable part of a daily diet. Mushrooms are rich in anti-inflammatory components such as polysaccharides, phenolic compounds, mycosteroids, fatty acids, carotenoids, vitamins, and biometals. The aqueous extract of fucogalactan from Agaricus bisporus, for example, exhibited an anti-inflammatory response in male Swiss mice. Additionally, heterogalactans isolated from Lentinus edodes have shown anti-inflammatory activities in male Swiss mice.
Edible mushrooms have been shown to regulate immunity in vitro, and they have a long history of use in traditional Oriental therapies. Hot-water-soluble fractions of medicinal mushrooms have been used as medicine in the Far East. Extracts of different mushrooms have shown significant decreases in the activities of inflammatory mediators, inhibiting macrophage functions and reducing cell inflammations. The in vivo effects of edible mushrooms on induced inflammatory responses are modest, which is not surprising as strongly inducing or suppressing immune function after ingestion could be harmful. Nevertheless, mushrooms are believed to possess multiple immunoregulatory components, including selenium, B vitamins, and polysaccharides.
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Magic mushrooms have been used since ancient times for their mind-healing properties
Mushrooms have been used extensively for their nutritional and medicinal value for thousands of years. They are rich in anti-inflammatory components such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins, and biometals. Prolonged inflammation can lead to inflammatory diseases such as arthritis, inflammatory bowel disease (IBD), and cancer.
Magic mushrooms, or psilocybin-containing mushrooms, have been used since ancient times for their mind-healing properties and to advance the quality of life. The use of magic mushrooms for healing and spiritual rituals dates back to 3000 BC among indigenous people in Central America. Rock art from around 9000–7000 BCE in Tassili, Algeria, is believed to depict psychedelic mushrooms and their effects on users. Similarly, prehistoric rock art in Spain suggests that Psilocybe hispanica was used in religious rituals 6,000 years ago.
The hallucinogenic species of the Psilocybe genus have been used by the native peoples of Mesoamerica for religious communion, divination, and healing since pre-Columbian times. A Psilocybe species known as "teōnanācatl" or "divine mushroom" in the Nahuatl language was reportedly served at the coronation of the Aztec ruler Moctezuma II in 1502.
In modern times, magic mushrooms are being studied for their potential to treat mental health disorders, including substance use disorders, depression, anxiety, obsessive-compulsive disorder, and post-traumatic stress disorder (PTSD). The compounds in magic mushrooms may help alter the perspective of individuals with "diseases of despair," such as suicide, drug overdose, and alcohol abuse. However, it is important to note that there are potential health risks associated with unsupervised use, and more research is needed to understand psilocybin's full potential as a medicine.
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Mushrooms are a natural way to treat chronic pain and may help retrain the brain away from it
Mushrooms have been used for their nutritional and medicinal value for thousands of years. They are rich in anti-inflammatory components, such as polysaccharides, phenolic and indolic compounds, mycosteroids, fatty acids, carotenoids, vitamins, and biometals. These anti-inflammatory properties can help treat inflammatory diseases such as juvenile idiopathic arthritis (JIA), inflammatory bowel disease (IBD), multiple sclerosis, rheumatoid arthritis, gastritis, bronchitis, and atherosclerosis.
Recent studies have also shown that mushrooms may be effective in treating chronic pain. A 2022 study found that psilocybin, the active ingredient in "magic mushrooms," may reduce chronic pain symptoms. Another study from the Journal of Pharmaceutical Biology concluded that oyster mushrooms can act as a "safe, short-acting, moderate to strong antinociceptive agent," meaning they can reduce pain.
Mushrooms are thought to help manage chronic pain by reducing inflammation in the central nervous system (CNS). This, in turn, may help retrain the brain away from chronic pain. Additionally, mushrooms may help to address the psychological impact of chronic pain, which conventional treatments often fail to acknowledge.
There are various ways to incorporate mushrooms into your diet or supplement routine to treat chronic pain. You can cook with certain types of mushrooms or take mushroom supplements in the form of powders, capsules, or extracts. However, it is important to carefully monitor your dosage and consult with your doctor to ensure safe use.
While research into the use of mushrooms for chronic pain is promising, it is still ongoing, and more evidence is needed to confirm the efficacy of mushroom therapy for different types of chronic pain conditions.
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Frequently asked questions
No, mushrooms are not inflammatory. Mushrooms have been used for thousands of years for their nutritional and medicinal value. They are a rich source of anti-inflammatory compounds, including polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules.
Mushrooms have been shown to decrease the activities of inflammatory mediators such as nitric oxide (NO), cytokines, and prostaglandins, thereby reducing cell inflammations. They also contain high amounts of selenium, vitamin D, and vitamin B6, which help maintain a healthy immune system.
Mushrooms offer a range of health benefits, including:
- Reducing inflammation and fighting infection
- Lowering cholesterol and blood pressure
- Improving weight loss
- Reducing the risk of cancer, heart disease, Alzheimer's, and diabetes
- Providing essential vitamins and minerals, such as vitamin D, vitamin B6, and potassium
There are six common types of functional mushrooms with unique properties and potential benefits, including reishi, chaga, and shiitake. White button, portabella, and cremini mushrooms are also recommended for their high levels of vitamin D when exposed to sunlight. Shiitake mushrooms are an excellent source of vitamin B6, and maitake mushrooms can help achieve the recommended daily vitamin D intake without sun exposure.

























