Michael Davis
Androgen antagonists, or anti-androgens, are drugs or compounds that reduce the levels or activity of androgen hormones in the human body. Androgen antagonists can suppress the action of male sex hormones such as testosterone, which is produced in both male and female bodies but is typically found in much higher levels in males. High testosterone levels in females can cause unwanted side effects such as acne, excess body hair, and male pattern baldness. While there are several medical treatments that act as androgen antagonists, there has been an increasing demand for alternative therapies, including plant-derived anti-androgens. One such example is red reishi mushroom, which has been shown to reduce levels of 5-alpha reductase, the enzyme that converts testosterone into dihydrotestosterone (DHT).
| Characteristics | Values |
|---|---|
| Reishi mushroom's scientific name | Ganoderma lucidum |
| Reishi mushroom's other names | Red reishi, lingzhi |
| Reishi mushroom's anti-androgen properties | Reduces levels of 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT) |
| Reishi mushroom's form | Dried or powdered |
| Reishi mushroom's use | Can be used to make tea, broth, or soup or added as powder to coffee |
| Reishi mushroom's benefits | Used for centuries in East Asia to treat various human diseases such as cancer, hypertension, hepatitis, nephritis, etc. |
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What You'll Learn
Reishi mushrooms and testosterone
Reishi mushrooms, scientifically known as Ganoderma lucidum, have been used in traditional Chinese medicine for thousands of years. They are believed to possess various healing properties, including the ability to manipulate androgen hormones such as testosterone.
The principal prostatic androgen is dihydrotestosterone (DHT), which is formed by the steroid enzyme 5α-reductase from its substrate testosterone. 5α-Reductase is a membrane-bound NADPH-dependent enzyme that catalyzes the reduction of testosterone to the more potent androgen, DHT. The effect of DHT is purely androgenic, and unlike testosterone, it cannot be transformed into estrogen.
Reishi mushrooms have been shown to reduce levels of 5-alpha reductase, the enzyme that facilitates the conversion of testosterone to DHT. In animal studies, the consumption of reishi mushrooms has been linked to lower testosterone levels, possibly due to the presence of compounds inhibiting the 5-alpha reductase. However, these findings have not been thoroughly studied in humans, and results may vary significantly.
In a study on male Wistar rats, ethanol extracts of Ganoderma lucidum were found to have aphrodisiac properties. The results showed a significant increase in mounting behaviour, mating performance, and the number of intromissions and ejaculations. This indicates that the extract may have a positive impact on male sexual dysfunction.
While reishi mushrooms have demonstrated anti-androgenic properties in animal models, it is yet to be conclusively shown whether they significantly alter human androgen levels or free testosterone levels. More research is needed to determine the definitive effect of reishi mushrooms on testosterone levels in humans.
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Reishi mushrooms and hirsutism
Reishi mushrooms, also known as Ganoderma lucidum or Ganoderma lingzhi, have been used in traditional Chinese medicine for centuries. The mushroom is typically red to orange in colour and fan-shaped. It has been referred to as the "King of Mushrooms" and is often consumed in powdered form in tea, broth, soup, or coffee.
Hirsutism is a condition characterised by excess hair growth in women, often driven by high levels of androgens, or male sex hormones, in the body. Common treatment options for hirsutism include shaving, waxing, plucking, sugaring, laser hair removal, IPL, and electrolysis. However, some women seek natural remedies to address the underlying hormonal imbalance that causes hirsutism.
Reishi mushrooms are thought to have anti-androgenic properties, meaning they may reduce the levels or activity of androgens in the body. Specifically, reishi mushrooms are believed to inhibit the enzyme 5-alpha reductase, which facilitates the conversion of testosterone to dihydrotestosterone (DHT). By blocking this conversion, reishi mushrooms may help reduce the levels of DHT, which is the androgen primarily responsible for the development of hirsutism.
While there is some preliminary evidence to support the anti-androgenic effects of reishi mushrooms, more comprehensive scientific research is needed to confirm their efficacy in treating hirsutism. Some small studies have shown that consuming two cups of reishi mushroom tea daily for 30 days may help lower testosterone levels and improve hirsutism symptoms. However, side effects of long-term consumption may include fluid retention and high blood pressure. Additionally, reishi mushrooms can cause allergic reactions, including dizziness, headaches, rashes, and itchiness.
It is important to consult with a doctor before consuming reishi mushrooms as a natural treatment for hirsutism, as they can advise on potential interactions or side effects based on individual health needs.
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Reishi mushrooms and acne
Acne is an inflammatory skin disease caused by a bacterial infection. The severity of acne and its progression are related to hormonal interactions, the production of sebum, and the effect of certain bacteria.
Reishi mushrooms, also known as Ganoderma lucidum, have been shown to have anti-inflammatory, antibacterial, and immunomodulatory properties, which can help to reduce skin inflammation caused by acne. Reishi also acts as a hormonal regulator, helping to control the androgen hormones that can interfere with acne production.
In traditional medicine, the fruiting body of the reishi mushroom has been used for centuries to treat various diseases, including cancer, hypertension, and hepatitis. Modern research has demonstrated the anti-androgenic activity of reishi mushrooms, inhibiting the enzyme 5-alpha reductase, which facilitates the conversion of testosterone to dihydrotestosterone (DHT).
Reishi mushrooms can be consumed in various forms, including tea, broth, soup, or as a dried powder added to other foods or beverages. Additionally, reishi mushroom face serums are available, which claim to reduce skin inflammation caused by acne and provide antioxidant protection to the skin.
It is important to note that while reishi mushrooms may provide some benefits for acne, individual results may vary, and it should not be considered a replacement for medical advice or treatment.
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Reishi mushrooms and androgenic alopecia
Reishi mushrooms, also known as Ganoderma lucidum, have been used as a medicinal treatment for over 2,000 years. In ancient China, they were regarded as the "herb of spiritual potency", with the earliest mentions of them dating back to around 207 B.C. They were initially used by royalty to extend life and boost health.
Today, reishi mushrooms are known for their potential health benefits, including their ability to slow premature hair loss and promote new, healthy hair growth. This is particularly relevant for individuals experiencing androgenic alopecia, a type of hair loss caused by the androgens testosterone and DHT (dihydrotestosterone).
Androgenic alopecia, also known as male or female pattern baldness, is a genetic condition that can result in gradual hair loss over several decades, sometimes beginning as early as the teenage years. It occurs when DHT attaches itself to receptor cells in the hair follicles, blocking the absorption of vital vitamins, minerals, and proteins. As a result, the hair follicles shrink, leading to slower hair growth and thinning hair shafts. Eventually, hair stops emerging from the follicles.
Reishi mushrooms have been shown to inhibit the enzyme 5-alpha reductase, which is responsible for converting testosterone into DHT. By reducing the levels of this enzyme, reishi mushrooms can help lower DHT levels in the body, thereby preventing hair loss and promoting hair regrowth. In a 2005 study, reishi mushrooms exhibited the strongest 5-alpha reductase inhibitory activity compared to 18 other species of mushrooms, with an effective rate of 70-80%.
To incorporate reishi mushrooms into your hair care routine, you can consume them in the form of tea, capsules, or dietary supplements. Alternatively, you can create a homemade shampoo or hair mask using reishi mushroom extract. It is important to consult with your doctor before using reishi mushrooms as a hair growth supplement, as they may interact with certain medications.
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Reishi mushrooms and polycystic ovarian syndrome (PCOS)
Reishi mushrooms, also known as Ganoderma lucidum, have been used for centuries in traditional Chinese medicine to support physical health, enhance longevity, and replenish the flow of energy or "Qi". In recent years, they have gained popularity as a natural testosterone blocker or anti-androgen.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in females, affecting up to 10-25% of the female population. It is characterised by insulin resistance, inflammation, and gut health issues, and can lead to infertility. While there is no known cure for PCOS, reishi mushrooms have been found to provide several benefits for managing the condition.
Reishi mushrooms have been shown to lower testosterone and androgen levels in women with PCOS. This is achieved by inhibiting 5-alpha reductase, the enzyme that converts testosterone into dihydrotestosterone (DHT). By blocking this conversion, reishi mushrooms help reduce unwanted hair growth and other androgen-related side effects in women with PCOS. Additionally, reishi mushrooms have anti-inflammatory properties, which can be beneficial for managing the chronic inflammation associated with PCOS.
Reishi mushrooms can be consumed in various forms, such as tea, broth, soup, or mushroom coffee. They can also be added as a supplement to one's diet in the form of dried mushroom powder or capsules. For PCOS, it is recommended to take a special blend that incorporates Reishi mushrooms, such as the Nourished Androgen Blocker, to ensure safe and effective dosing.
While Reishi mushrooms have shown promising results in managing PCOS symptoms, it is important to note that they should be used as a complementary treatment alongside other lifestyle changes, such as improvements in diet and movement. Additionally, it is always advisable to consult with a healthcare professional before starting any new supplement or natural therapy.
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Frequently asked questions
Anti-androgens are drugs or compounds that reduce the levels or activity of androgen hormones in the body. They are used to treat conditions such as polycystic ovarian syndrome, hirsutism, acne, and male pattern baldness.
Yes, red reishi mushrooms, also known as Ganoderma lucidum, have been shown to exhibit anti-androgenic properties. They inhibit the activity of 5-alpha-reductase, an enzyme responsible for converting testosterone into dihydrotestosterone (DHT).
You can consume reishi mushrooms by making tea, broth, or soup using dried mushrooms or adding dried mushroom powder to coffee or other beverages.
While reishi mushrooms are generally considered safe, it is always advisable to consult a healthcare professional before incorporating them into your diet, especially if you are taking any medications or have any health conditions.
Yes, other natural compounds with anti-androgenic properties include spearmint tea, licorice root, green tea, saw palmetto, and chaste tree. These options are often sought by those who wish to avoid medication and explore natural alternatives.
