
Active Hexose Correlated Compound (AHCC) is a nutritional supplement derived from the mycelia of shiitake (Lentinula edodes) mushrooms. It is widely used for general health maintenance and the treatment of various diseases. AHCC is believed to have immune-boosting properties and is often used as a complementary and alternative medicine (CAM) for immune support. While the exact mechanism of its effects is not fully understood, studies have suggested that AHCC supplementation may positively impact immune outcomes and immune cell populations, indicating potential anti-inflammatory effects.
| Characteristics | Values |
|---|---|
| What is AHCC | Active Hexose Correlated Compound |
| What is it derived from | Mycelia of shiitake mushrooms or Lentinula edodes |
| Benefits | Used for general health maintenance, treatment of various diseases, immune support, and cancer therapy |
| Effectiveness | Research into its effectiveness is uncertain and inconclusive |
| Composition | Polysaccharides, beta-glucan, partially acylated α-glucan, and alpha-glucans |
| Manufacturer | Amino Up Co., Ltd. |
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What You'll Learn

Shiitake mushrooms contain AHCC
Shiitake mushrooms, or Lentinula edodes, are a type of edible fungus native to Japan and China. They are the second most commonly consumed mushrooms worldwide and are also popular in the cuisines of many Eastern countries. Active hexose correlated compound (AHCC) is a proprietary extract derived from the mycelia of shiitake mushrooms.
AHCC is a popular alternative medicine in Japan and is also widely used worldwide for general health maintenance and the treatment of various diseases. It is often used as a complementary and alternative medicine (CAM) for immune support, as reports in animal and clinical settings have indicated that AHCC is associated with an enhanced response to infection and increased survival. In Japan, it is the second most popular complementary and alternative medicine used by cancer patients.
AHCC is believed to have anti-inflammatory and anticancer effects, enhance resistance to microbial infections, and protect against oxidative stress-induced disorders. It has been studied for its role in the immune system, cancer, liver disease, and Human Papillomavirus (HPV). Small studies have shown benefits, but more extensive clinical trials are needed before AHCC can be routinely recommended. In healthy adults, AHCC improved T-cell immune responses, increased dendritic cell number and function, and improved antibody response to the influenza vaccine.
AHCC is a nutritional supplement that is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects. Polysaccharides form a large part of the composition of AHCC, including beta-glucan (β-glucan) and partially acylated α-glucan. Glucans are saccharides, some of which are known to have immune-stimulating effects. AHCC is believed to act as an immune modulator, as immune cells such as CD4+ and CD8+ T cells and natural killer (NK) cells will produce cytokines.
Shiitake mushrooms are likely safe when cooked and eaten in food amounts. A specific extract called AHCC is possibly safe in doses ranging from 4.5 to 6 grams daily for up to 6 months or 3 grams daily for up to 9 years. However, shiitake mushrooms may be unsafe when used in larger amounts as medicine or when eaten uncooked. Potential side effects include stomach discomfort, blood abnormalities, skin swelling, increased sun sensitivity, allergic skin reactions, and breathing problems. Individuals with mushroom allergies should proceed with caution when taking AHCC.
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AHCC is an immune booster
Active Hexose Correlated Compound (AHCC) is a group of chemicals derived from the mycelia of shiitake mushrooms (Lentinus edodes). It is a popular nutritional supplement used to boost the immune system and is often used as a complementary and alternative medicine (CAM).
AHCC is believed to enhance immune responses and increase resistance to infections. Studies have shown that it may reduce symptoms, improve survival rates, and shorten recovery time in animal models infected with viruses, bacteria, and fungi. AHCC has also demonstrated anti-inflammatory effects and may protect against oxidative stress-induced disorders.
The exact mechanism of how AHCC affects the immune system is not yet fully understood, but it is thought to involve the modulation of immune cells such as natural killer (NK) cells and T cells. AHCC may also affect the function of monocytes, macrophages, and dendritic cells (DCs), which play a role in promoting T cell function. In addition, the polysaccharides in AHCC, such as beta-glucans and partially acylated alpha-glucans, are known to have immune-stimulating effects. These polysaccharides stimulate receptors on human immune cells in the gut, helping to recognize and fight foreign pathogens such as viruses and bacteria.
While AHCC is widely used and has been the subject of over 100 scientific publications, more research is needed to fully understand its efficacy and potential therapeutic benefits. It is important to consult with a healthcare professional before taking AHCC, as it may interact with certain medications.
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AHCC is used as an alternative cancer treatment
Active hexose correlated compound (AHCC) is a popular alternative medicine in Japan. It is a group of chemicals derived from the mycelia of shiitake (Lentinus edodes) mushrooms. AHCC is a nutritional supplement that contains alpha-1,4-glucan oligosaccharides, amino acids, and minerals. It is believed to have anti-inflammatory and anticancer effects.
AHCC is widely used around the world for general health maintenance and the treatment of various diseases. It is often used as a complementary and alternative medicine (CAM) for immune support, as reports suggest that it enhances the response to infection and increases survival. In Japan, AHCC is the second most popular complementary and alternative medicine used by cancer patients.
AHCC has been proposed as a treatment for cancer, but research into its effectiveness has produced uncertain and inconclusive evidence. However, studies have suggested that AHCC supplementation may affect immune outcomes and immune cell populations, indicating anti-inflammatory effects. AHCC is also believed to have immunostimulatory effects and may improve prognosis and prevent recurrence after curative resection of hepatocellular carcinoma.
In a small study of 34 healthy adults, supplementing with AHCC was found to offset the seasonal dip in immunity that typically occurs during winter. Additionally, AHCC has been shown to lower the side effects of certain medications in people with pancreatic cancer. It has also been studied as an add-on treatment for people with liver cancer who have undergone a liver resection.
It is important to note that while AHCC is widely used, there is insufficient research to confirm its effectiveness as a cancer treatment. Herbal supplements like AHCC can interact with medications and affect their function. Therefore, it is crucial to consult a healthcare professional before taking AHCC or any other supplement.
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AHCC is an anti-inflammatory
Active Hexose Correlated Compound (AHCC) is a group of chemicals derived from the mycelia of shiitake (Lentinus edodes) mushrooms. It is a popular alternative medicine in Japan, where it is the second most popular complementary and alternative medicine used by cancer patients.
AHCC is believed to have anti-inflammatory properties. Studies have suggested that AHCC supplementation may affect immune outcomes and immune cell populations, indicating its anti-inflammatory effects. AHCC has been shown to improve T-cell immune responses and increase dendritic cell number and function. In combination with Bifidobacterium longum, AHCC has been shown to modulate T regulatory and dendritic cell phenotypes to favour anti-inflammatory responses after antibiotic use.
AHCC is also believed to have immunomodulatory functions, enhancing the body's response to infection and increasing survival. It has been proposed as a treatment for cancer, with studies showing its anti-cancer effects. However, research into its effectiveness as a cancer treatment has produced inconclusive results.
The exact mechanism of how AHCC affects the immune system is not yet fully understood. While mushrooms have been used in traditional medicines for various health conditions, the specific effects of mushroom extracts on the immune system require further investigation. Nonetheless, AHCC is widely used for general health maintenance and the treatment of various diseases.
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AHCC is a nutritional supplement
AHCC (Active Hexose Correlated Compound) is a nutritional supplement derived from the mycelia of shiitake (Lentinula edodes) mushrooms. It is composed primarily of polysaccharides, including beta-glucan and partially acylated alpha-glucan, which are thought to be responsible for its immune-stimulating effects.
Shiitake mushrooms have been used in traditional medicines for many years, and modern research has focused on the potential health benefits of mushroom extracts. AHCC is produced by culturing the mycelia, which are the root-like parts of the fungus, in an antiviral-rich rice bran extract for up to two months. This process results in a supplement that is rich in alpha-glucans, which enhance absorption and efficacy.
AHCC is widely used as a complementary and alternative medicine (CAM), particularly in Japan, where it is the second most popular CAM used by cancer patients. It is often taken to boost the immune system and support general health maintenance. AHCC has been studied for its potential anti-inflammatory, anticancer, and immunomodulatory effects. However, it is important to note that research into the effectiveness of AHCC is ongoing, and there is currently insufficient evidence to recommend its use as a treatment.
Some studies have suggested that AHCC may improve immune function and reduce symptoms in animal models of infections, inflammatory diseases, and cancer. For example, AHCC has been shown to improve T-cell immune responses, increase resistance to bacterial and viral infections, and enhance survival in animal models. Additionally, AHCC has been proposed as a potential treatment for human papillomavirus (HPV) infection, which can lead to cervical cancer. However, more research is needed to confirm these findings and fully understand the pharmacology and mechanisms of action of AHCC.
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Frequently asked questions
AHCC is an extract from the mycelia of shiitake mushrooms and is used as a supplement to boost the immune system. It is also used to treat various diseases and infections and is a popular alternative medicine in Japan.
Shiitake mushrooms, also known as Lentinula edodes, contain AHCC.
AHCC is rich in alpha-glucans, which increase its absorption and efficacy. It also contains polysaccharides, which stimulate receptors in human immune cells that recognize foreign pathogens.
The recommended dosage of AHCC may vary depending on the individual's health and needs. It is always best to consult a healthcare professional before taking any supplements.

























