
Shiitake mushrooms are a popular food source with a long history of use in traditional Chinese medicine and the medical traditions of Japan, Korea, and Eastern Russia. They are also cultivated and consumed worldwide for their taste and health benefits. When is the best time to take shiitake mushrooms, though? Shiitake mushrooms are likely safe when cooked and eaten in food amounts. However, they may be unsafe when consumed in larger amounts as medicine or when eaten raw. It is important to consult a healthcare professional before taking shiitake mushrooms as natural products can have side effects and interact with medications.
| Characteristics | Values |
|---|---|
| Safety | Shiitake mushrooms are likely safe when cooked and eaten in food amounts. |
| An extract called AHCC is possibly safe in doses of 3-6 grams daily for up to 6 months or 3 grams daily for up to 9 years. | |
| Shiitake mushrooms may be unsafe when used in larger amounts as medicine, or when eaten uncooked. | |
| They can cause stomach discomfort, skin swelling, and allergic skin reactions. | |
| They may also make the skin more sensitive to the sun and cause breathing problems in some people. | |
| There is not enough information to determine whether they are safe during pregnancy or breastfeeding. | |
| They might cause the immune system to become more active in people with autoimmune diseases such as multiple sclerosis (MS) or rheumatoid arthritis (RA). | |
| They might change how quickly the liver breaks down certain medications, altering their effects and side effects. | |
| Health Benefits | Shiitake mushrooms are a good source of key vitamins and minerals, including vitamin D, B vitamins, and copper. |
| They contain compounds that may help lower cholesterol, reduce inflammation, and boost immune function. | |
| They have antibacterial, antiviral, and antifungal properties, and may help fight cancer and infections. | |
| They may promote bone health, improve circulation, and support heart health. | |
| They may also help regulate and support the immune system, maintain healthy body weight, and maintain brain function as you age. | |
| They are popular in cooking due to their meaty texture and versatile flavor. | |
| Preparation | Shiitake mushrooms can be purchased dried, cooked, or raw, and added to various dishes such as soups, salads, stir-fries, and meat dishes. |
| They can be cooked in a variety of ways, including sautéing, pan-frying, and grilling. |
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What You'll Learn

Safe consumption
Shiitake mushrooms are the third most popular mushroom in the world and are used widely in cooking. They are also used in traditional Chinese medicine and the medical traditions of Japan, Korea, and Eastern Russia.
Shiitake mushrooms are likely safe to consume when cooked and eaten in food amounts. However, raw shiitake mushrooms can cause an allergic reaction in some people, resulting in itchy and uncomfortable skin dermatitis. Cooking the mushrooms can avoid this reaction, but it may reduce the health benefits from the lentinan compound.
In rare cases, people can develop a skin rash from eating or handling raw shiitake. In addition, using powdered mushroom extract over a long period may cause other side effects, including stomach upset and sensitivity to sunlight.
Shiitake mushrooms may also interfere with certain medications. They could change how quickly the liver breaks down these medications, altering their effects and side effects.
There is not enough information to determine whether shiitake mushrooms are safe for pregnant or breastfeeding women.
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Potential health benefits
Shiitake mushrooms are the third most popular mushrooms in the world and have been used in traditional Chinese medicine for over a thousand years. They are also part of the medical traditions of Japan, Korea, and Eastern Russia. In these cultures, shiitake mushrooms are thought to boost health and longevity, as well as improve circulation. Here are some of their potential health benefits:
Heart Health
Shiitake mushrooms contain eritadenine, a compound known to reduce cholesterol levels in the blood. They also contain beta-glucans that reduce inflammation and help prevent the intestines from absorbing cholesterol. Several compounds in shiitake have been shown to lower cholesterol and may reduce your risk of heart disease.
Immune Support
Shiitake mushrooms are rich in polysaccharides like lentinans and other beta-glucans, which protect against cell damage, help your immune system, and boost white blood cell production for fighting off microbes. Polysaccharides also have anti-inflammatory properties. A study of 52 adults showed that consuming 5-10 shiitake mushrooms daily for four weeks improved immunity.
Bone Health
Shiitake mushrooms are one of the few natural food sources of vitamin D, which is essential for calcium absorption and bone health. The vitamin D levels of mushrooms vary depending on how they are grown, with those exposed to UV light developing higher levels of this compound. Shiitake with higher vitamin D levels may improve your bone density.
Cancer Prevention
Studies suggest that some of the bioactive compounds in shiitake mushrooms may protect against cancer. Lentinan, a polysaccharide in shiitake, may help fight cancer. Beta-glucans found in shiitake have been used in Japan to stimulate the immune system during cancer treatment, and research also shows that they may protect against certain tumors. However, it is important to note that many of the studies on the anticancer effects of shiitake have been done in animals or test tubes rather than humans, and more research is needed.
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Side effects and risks
Shiitake mushrooms are generally safe to eat when cooked and consumed in food amounts. However, there are some potential side effects and risks associated with their consumption, especially when eaten raw, in large amounts, or by certain individuals. Here are some key points to consider:
Allergic Reactions and Skin Problems
Shiitake mushrooms can cause allergic reactions in some individuals. These reactions can range from skin rashes, known as shiitake dermatitis, to more severe anaphylaxis, which can cause breathing difficulties and loss of consciousness. People with known mushroom allergies should avoid shiitake mushrooms and related products to prevent allergic reactions.
Gastrointestinal Issues
Consumption of shiitake mushrooms, especially in the form of mushroom powder, has been associated with gastrointestinal symptoms such as abdominal discomfort and increased eosinophil levels in the blood and stool. These symptoms may be more prevalent in individuals with an intolerance to mushrooms or digestive issues.
Blood Abnormalities and Increased Bleeding Risk
Shiitake mushrooms contain eritadenine, a compound with blood-thinning effects. This can increase the risk of bleeding, especially in individuals already taking blood-thinning medications or those with bleeding disorders. Additionally, shiitake mushrooms may cause other blood abnormalities, although the exact nature of these abnormalities requires further research.
Drug Interactions
Shiitake mushrooms may interact with certain medications. They can affect how quickly the liver breaks down drugs, potentially altering their effectiveness and side effects. Individuals taking prescription medications should consult a healthcare professional before consuming significant amounts of shiitake mushrooms.
Autoimmune Diseases
Shiitake mushrooms might stimulate the immune system, which could be detrimental to individuals with autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis, or similar conditions.
Sun Sensitivity
Shiitake mushrooms may increase skin sensitivity to sunlight, potentially raising the risk of sunburn or other skin damage when spending time in the sun after consumption.
It is important to note that the side effects of shiitake mushrooms are relatively uncommon and mostly associated with excessive consumption or individual sensitivities. Cooking and consuming shiitake mushrooms in moderate amounts as part of a meal is generally considered safe for most people. However, it is always advisable to consult a healthcare professional before introducing new substances into your diet, especially if you have any pre-existing health conditions or concerns.
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Traditional medicine
Traditional herbal medicine has long recognised the health benefits of shiitake mushrooms. They are mentioned in books written thousands of years ago.
Shiitake mushrooms are edible fungi native to East Asia. They are the third most popular mushroom worldwide, after oyster and white button mushrooms. They are versatile and can be cooked and eaten or taken as a supplement. They are also available dried and fresh. However, it is important to note that they should be cooked before eating, as raw shiitake mushrooms can cause skin dermatitis in some people.
Shiitake mushrooms are a good source of vitamins and minerals. They contain eritadenine, which is known to reduce cholesterol levels in the blood. They also contain beta-glucans, which have anti-inflammatory properties and help prevent the intestines from absorbing cholesterol. They are also a source of vitamin D, which is important for bone health and reducing the risk of heart disease, diabetes, and some types of cancer.
In traditional medicine, shiitake mushrooms are used for boosting the immune system, lowering blood cholesterol, and treating cancer. They contain chemical compounds that may help fight cancer cells and heal chromosome damage caused by anti-cancer treatments. They also contain sterol compounds that interfere with the production of cholesterol in the liver.
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Cooking and recipes
Shiitake mushrooms are a versatile ingredient that can be used in a variety of dishes. They are commonly used in Asian cooking, particularly in Japanese and Chinese cuisine, and are known for their strong, earthy flavour and meaty texture. Here are some tips and recipes to help you make the most of these delicious mushrooms.
Preparation
Before cooking, it is important to clean the mushrooms. You can do this by gently wiping them with a wet paper towel to remove any dirt. Alternatively, you can rinse them quickly under cold water, but be aware that shiitake mushrooms absorb moisture, so be sure to shake off any excess water or pat them dry with a paper towel.
Sautéing
Sautéing is a quick and easy way to cook shiitake mushrooms, and it brings out their deep, rich umami flavour. To sauté the mushrooms, heat some butter and olive oil in a large skillet over medium heat. You can also use a mix of sesame oil and salted butter for a more intense flavour. Once the skillet is hot, add the mushrooms and let them sit without stirring for about 3 minutes to create a lovely caramelization. Then, stir and cook for another 2 minutes.
For added flavour, you can include some white wine, cooking sherry, or soy sauce, cooking for an additional 2 minutes. Finally, stir in some garlic and parsley, and cook for another minute before serving. Season with salt and pepper, and garnish with herbs if desired.
Roasting
If you're looking for a smoky, charred flavour, try roasting your shiitake mushrooms. Marinate whole mushrooms or thick slices in a mixture of soy sauce, sesame oil, and garlic. Thread them onto skewers and grill over medium heat for 3-5 minutes per side, brushing with extra marinade for maximum flavour.
Simmering
For a softer, more tender texture, try simmering your shiitake mushrooms. This method is perfect for plant-based ramen broth or stews. Simply rehydrate dried shiitake mushrooms in warm water for 20-30 minutes before slicing or leaving them whole and simmering them in broths, stews, or sauces.
Recipes
Shiitake mushrooms make a delicious side dish and can be served with eggs, mashed potatoes, steak, or sandwiches. They also pair well with pho, ramen, stir-fries, soups, and salads. For a simple recipe, try sautéing shiitake mushrooms with butter, garlic, and fresh parsley, then pan-frying until tender and caramelized.
Remember, shiitake mushrooms should always be fully cooked before eating to avoid any potential health risks. With their versatile flavour and texture, they are a great addition to any meal!
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Frequently asked questions
Shiitake mushrooms can be taken at any time of day. They can be cooked and eaten or taken as a supplement.
There is no consensus on the appropriate dose of shiitake mushrooms. However, a specific extract called AHCC is possibly safe in doses of 4.5-6 grams daily for up to 6 months or 3 grams daily for up to 9 years.
Shiitake mushrooms are likely safe when cooked and eaten in food amounts. However, they may cause skin rashes and dermatitis in rare cases. They can also cause stomach discomfort, blood abnormalities, and skin swelling when taken in large amounts.

























