
The use of psychedelic mushrooms, also known as shrooms, magic mushrooms, or truffles, can lead to a range of experiences, from spiritual to recreational. However, the day after a trip, some people may experience a shroom hangover, which can include headaches, nausea, and general discomfort. While the cause of shroom hangovers is not yet fully understood, it is believed that nitric oxide and serotonin may play a role. Additionally, individual factors such as hydration levels and the amount of psilocybin ingested can also influence the likelihood and severity of a hangover. Although the hangover symptoms are typically mild and transient, they can be alleviated through painkillers, rest, and hydration.
| Characteristics | Values |
|---|---|
| Can psychedelic mushrooms cause a hangover? | Yes, some people experience a "shroom hangover" after consuming psychedelic mushrooms, or "shrooms." |
| Symptoms | Headaches, nausea, and general discomfort are common symptoms associated with a shroom hangover. |
| Causes | The exact cause of shroom hangovers is not fully understood, but clinical observations suggest that nitric oxide and serotonin may play a role. Staying hydrated before and after consuming shrooms may help prevent headaches. |
| Duration | The effects of shrooms typically last around 6 hours, but lingering effects can be felt into the next day. Most people return to feeling like themselves within 24 hours. |
| Relief | Staying hydrated, taking painkillers, sleeping, and drinking plenty of water may help alleviate hangover symptoms. Serotonin supplements can also be taken to relieve headaches. |
| Prevention | Proper preparation, such as staying hydrated, can help prevent shroom hangovers. Avoiding the combination of shrooms with alcohol, weed, or other drugs can also reduce the risk of a hangover. |
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What You'll Learn
- Shroom hangovers are likely caused by nitric oxide and serotonin
- The severity of the hangover depends on the species of mushroom
- Shroom hangovers are less severe than alcohol hangovers
- Shroom hangovers can be treated with painkillers, sleep and water
- Shroom hangovers can be prevented by staying hydrated

Shroom hangovers are likely caused by nitric oxide and serotonin
While the exact causes of shroom hangovers are not yet fully understood, clinical observations have suggested that nitric oxide and serotonin may play a significant role.
Shroom hangovers, characterised by headaches, nausea, and general discomfort, can occur after consuming psilocybin mushrooms, regardless of the dose. However, the presence and severity of a shroom hangover can vary depending on individual factors and experiences.
Nitric oxide (NO), a free-radical gas with vasorelaxant effects, is often used in studies to induce migraines. Research has shown that LSD suppresses the release of NO, and it is believed that psilocybin, the active substance in shrooms, may have similar effects. Additionally, anti-migraine medications have been found to potentially reduce NO production, further suggesting a link between NO and headaches.
Serotonin, a neurotransmitter involved in mood regulation, also appears to be implicated in shroom hangovers. Psilocybin mimics serotonin, binding to serotonin receptors and creating a sense of well-being. However, when the direct pharmacological effects of psilocybin wear off, there may be a super-sensitivity to serotonin in isolated parts of the brain, leading to a hangover-like experience. It is important to note that psilocybin does not deplete serotonin levels in the brain, as seen with other drugs like MDMA.
While the exact mechanisms are still unclear, understanding the potential involvement of nitric oxide and serotonin in shroom hangovers provides valuable insights into managing the after-effects. Staying hydrated, getting adequate rest, and consuming supplements like vitamin D, probiotics, and CBD can help alleviate the transient ill effects of shroom hangovers.
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The severity of the hangover depends on the species of mushroom
While the effects of a shroom hangover are not as severe as those of a hangover from a night of binge drinking, some people do experience headaches, nausea, and a general feeling of being unwell. The severity of these symptoms may depend on various factors, including the species of mushroom consumed.
There are between 75 and 200 different species of psilocybin-containing mushrooms, and the amount of the hallucinogen varies from one mushroom to another. The more psilocybin in the mushroom, the longer it will stay in the body. The duration of the effects of magic mushrooms depends on several factors, including the species of mushroom ingested, as well as the individual's age and body composition.
Some people report feeling the effects of magic mushrooms for longer than the average trip duration of 3 to 6 hours, with lingering effects lasting into the next day. However, within 24 hours, most people return to feeling like themselves. It is recommended to take the day off after consuming magic mushrooms and avoid engaging in sports or other intensive activities, as concentration may be affected.
The active substance in magic mushrooms, psilocybin, has been shown to cause headaches in a dose-dependent manner. Higher doses of psilocybin are more likely to result in headaches, and the incidence, duration, and severity of headaches increase with higher doses. Additionally, psilocybin may interact with serotonin in the brain, potentially contributing to hangover symptoms. However, more research is needed to fully understand the role of serotonin and nitric oxide in shroom hangovers.
To alleviate hangover symptoms, it is recommended to stay hydrated, take painkillers if needed, and get plenty of sleep. Some people also find supplements such as vitamin D, functional mushrooms, probiotics, and CBD helpful for supporting the mind and body before, during, and after a psychedelic experience.
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Shroom hangovers are less severe than alcohol hangovers
While there is limited research on shroom hangovers, they are known to be less severe than alcohol hangovers. Shroom hangovers are characterised by headaches, nausea, and a general feeling of being unwell. However, these effects are transient and can be alleviated by taking painkillers, staying hydrated, and getting enough sleep.
The active substance in shrooms, psilocybin, is a well-known hallucinogen that can cause visual and auditory hallucinations. It is rapidly metabolised and eliminated from the body, with most people feeling back to normal within 24 hours. The length of time psilocybin stays in the system depends on various factors, such as the species of mushroom, age, and body composition.
In comparison, alcohol hangovers can be much more intense and prolonged. They can cause severe headaches, dehydration, nausea, and even vomiting and diarrhoea. The severity of alcohol hangovers can vary depending on the amount consumed and individual tolerance levels.
While shroom hangovers might not be as debilitating as alcohol hangovers, it is important to approach shrooms with caution. Combining shrooms with other substances, such as alcohol or drugs, can increase the risk of negative experiences and should be avoided. Additionally, it is crucial to stay hydrated and prepare adequately before taking shrooms to minimise the chances of experiencing a hangover.
Overall, while shroom hangovers exist, they are typically milder than alcohol hangovers, and the ill effects are temporary. By taking the necessary precautions and listening to your body, you can minimise the impact of a shroom hangover and safely navigate the post-trip experience.
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Shroom hangovers can be treated with painkillers, sleep and water
While the causes of shroom hangovers are not well understood, there are a few ways to treat the symptoms. The ill effects of a shroom hangover are transient, so popping a painkiller, getting some sleep, and staying hydrated by drinking plenty of water may help alleviate the symptoms.
In addition to these remedies, there are also several supplements that can support your mind and body before, during, and after a psychedelic journey. These include vitamin D, functional mushrooms (such as lion's mane, cordyceps, and reishi), probiotics, and CBD. These supplements can help to rebalance your body, ease emotional distress, and boost immune and gut health.
It is important to note that the research on shroom hangovers and the role of serotonin and nitric oxide (NO) is not definitive. However, clinical observations suggest that NO and serotonin may play a significant role in causing shroom hangovers. For example, in studies where migraines are induced, NO is often used, and research has shown that LSD suppresses the release of NO. It is believed that psilocybin, the active compound in magic mushrooms, has similar effects.
If you are experiencing a shroom hangover, it is important to give yourself time to recuperate and listen to what your body needs. The symptoms will pass, and there is no need to worry.
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Shroom hangovers can be prevented by staying hydrated
Although the exact causes of shroom hangovers are not yet fully understood, some people do experience hangover-like symptoms after taking psychedelic mushrooms. These symptoms can include fatigue, headaches, nausea, muscle aches, and difficulty concentrating. The severity and duration of a shroom hangover can vary from person to person and may depend on factors such as dosage and individual metabolism.
To prevent and alleviate the symptoms of a shroom hangover, staying hydrated is crucial. Drinking plenty of water before, during, and after consuming shrooms can help minimize dehydration, which is often a contributing factor to hangover symptoms. In addition to water, consider including other hydrating beverages and foods in your diet, such as electrolyte-rich sports drinks, coconut water, and fruits and vegetables with high water content. It is also important to avoid alcohol and caffeinated beverages, as they can further dehydrate you.
By staying hydrated, you can help your body replenish the fluids and minerals lost during the shrooms experience. This, in turn, can aid in reducing symptoms such as headaches and nausea. However, it is important to note that staying hydrated is just one aspect of managing a shroom hangover. Getting enough rest, consuming nutritious foods, and taking certain supplements can also help support your overall well-being and speed up your recovery.
Some people have reported that when they stay hydrated before and during their mushroom trips, they are less likely to experience a hangover. However, it is important to listen to your body and drink when you feel thirsty. While staying hydrated is a crucial aspect of preventing and managing a shroom hangover, it may not be the only solution. Combining hydration with other self-care practices, such as rest and proper nutrition, can help you effectively recover from a shroom hangover.
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Frequently asked questions
Yes, some people experience a hangover after taking psychedelic mushrooms. However, it is not as bad as a hangover from a night of binge drinking.
The symptoms of a psychedelic mushroom hangover include headaches, nausea, and an overall feeling of being unwell.
The cause of a psychedelic mushroom hangover is not yet fully understood. However, research suggests that nitric oxide and serotonin may play a role.
There are a few things that may help alleviate the symptoms of a psychedelic mushroom hangover. These include staying hydrated, taking painkillers, getting plenty of sleep, and drinking water.

























