
Nootropics, also known as smart drugs, are a diverse group of substances that enhance human cognition and memory, especially in cases where these functions are impaired. Mushroom nootropics have been marketed as substances that enhance cognitive function. However, there are safety concerns regarding these products. In this regard, it is important to understand the potential benefits and risks associated with consuming mushroom nootropics.
| Characteristics | Values |
|---|---|
| Safety | Nootropics are generally well-tolerated and have minimal side effects. However, they may contain undisclosed ingredients and have been linked to severe illness. |
| Side Effects | Mild side effects may include fatigue, headache, nausea, and allergic reactions. More severe side effects can include hallucinations, agitation, gastrointestinal upset, and seizures. |
| Populations | Not suitable for those who are pregnant or breastfeeding. Not recommended for those with bleeding disorders, on blood-pressure-lowering medication, or with mushroom allergies. |
| Drug Interactions | May interact with blood-thinning medications, blood-pressure-lowering drugs, anti-inflammatory medications, chemotherapy drugs, and anticoagulants. |
| Dosage | No standard dosage for mushroom nootropics. Dosage depends on factors such as age, overall health, and specific product. |
| Regulation | Dietary supplements in the United States don't undergo FDA review for safety and effectiveness. |
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What You'll Learn

Side effects of mushroom nootropics
Nootropics, also known as "smart drugs", are a group of medicinal substances that improve human cognitive functions, especially in cases where these functions are impaired. While nootropics are usually well tolerated, and side effects are rare and typically mild, certain complications can occur.
Some common side effects of nootropics include non-specific rashes, headaches, inflammation of the oral mucosa, acute pancreatitis, diarrhea, nausea, and loss of appetite. Additionally, certain nootropics may increase anxiety in sensitive individuals, and some individuals may experience brain fog due to overstimulation, neurotransmitter imbalances, or withdrawal effects.
Mushroom nootropics, such as Lion's Mane, Cordyceps, and Reishi, are generally considered safe and well-tolerated when taken as supplements. However, some studies have reported side effects such as dizziness and headaches. Certain populations should avoid consuming these mushrooms, including people with bleeding disorders, those taking blood-pressure-lowering medications, and pregnant or breastfeeding women. Furthermore, there have been rare cases of liver toxicity associated with the consumption of Reishi powder.
It is important to note that the safety of mushroom nootropics largely depends on their source and purity. Poor-quality ingredients may contain contaminants, heavy metals, or pesticide residues, which can lead to adverse effects. Additionally, some mushroom nootropics may interact with other medications, such as antidepressants or blood-thinning drugs.
In conclusion, while mushroom nootropics can offer cognitive benefits, it is crucial to carefully select high-quality products and consult a healthcare professional to ensure their safe and appropriate use.
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Safety regulations of mushroom nootropics
Nootropics, also known as "smart drugs", are a diverse group of substances that enhance human cognitive functions, particularly in cases where these functions are impaired. They are often used by university students to improve memory and thinking. While nootropics tend to be well-tolerated by patients with cognitive impairments, their long-term effects on healthy individuals are still unknown.
Mushroom nootropics, such as those containing the hallucinogenic mushroom Amanita muscaria, have been linked to severe illness. In one case, five people required hospital evaluation after ingesting nootropic gummies labelled to contain A. muscaria but instead contained unlabelled, potentially harmful substances, including the Drug Enforcement Administration (DEA) schedule I substances psilocybin and psilocin. A. muscaria itself can also cause hallucinations, agitation, gastrointestinal upset, and seizures.
Adaptogenic mushrooms, such as lion's mane, cordyceps, and reishi, have been shown to have good safety and tolerability profiles when taken as supplements. However, certain populations should avoid these mushrooms, such as those with bleeding disorders, people taking blood-pressure-lowering medication, and pregnant or breastfeeding women. Additionally, there have been rare cases of liver toxicity associated with reishi consumption.
It is important to consult a healthcare provider before taking any mushroom nootropics to ensure they are safe and appropriate for your individual needs. Some nootropics may interact with common medications, such as blood-thinning or blood-pressure-lowering drugs, and certain populations may be at higher risk for adverse effects. While some nootropics are available without a prescription, working with a healthcare provider can help ensure the supplement is obtained from a reputable and sustainable source.
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Nootropic gummies containing Amanita muscaria
From September 2023 to June 2024, five patients, including one child, were evaluated in Virginia after ingesting gummies labelled to contain Amanita muscaria. The patients experienced symptoms such as tachycardia, confusion, anxiety, somnolence, nausea, and chest pain.
Investigators purchased and tested several brands of mushroom nootropic gummies. Four out of six bags tested were found to contain unlabelled psilocybin or psilocin, which are Schedule I substances not legal in Virginia. Additional unlabelled substances found included caffeine, ephedrine, and mitragynine, an opioid agonist.
Amanita muscaria is known to contain ibotenic acid and muscimol, and can cause undesired symptoms such as gastrointestinal upset, agitation, and seizures. It may also interact with certain medications and can be potentially dangerous for those with epilepsy.
Some popular brands of Amanita muscaria gummies include Premium Jane, Galaxy Treats Moon Shrooms, and Koi. It is recommended that consumers speak with their doctor before trying Amanita muscaria gummies or other supplemental products.
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Adaptogenic mushrooms
Adaptogens are plants and mushrooms that help the body respond to stress, anxiety, fatigue, and overall well-being. Adaptogens bring the body back to a steady balance by managing both physical and mental stressors. Adaptogens are non-toxic when taken in normal doses and allow the body to return to balance (homeostasis).
Research studies have shown that lion's mane, cordyceps, and reishi mushrooms generally have good safety and tolerability when taken in supplement form. However, some studies have reported side effects such as dizziness and headaches. People with bleeding disorders, those taking blood-pressure-lowering medication, and those who are pregnant or breastfeeding should not use reishi mushrooms. Additionally, there have been two documented cases of liver toxicity related to the consumption of reishi powder.
Cordyceps is a type of fungus studied for its potential to reduce the effects of stress on the body. Research in humans is limited, but studies in rodents suggest that cordyceps may reduce stress-related markers and increase resistance to stress-inducing activity.
Lion's mane, also known as Hericium erinaceus, is another mushroom thought to offer adaptogenic effects. Rodent studies have shown that lion's mane extract may help reverse stress-related changes to neurotransmitters, including dopamine and serotonin. It may also reduce levels of inflammatory markers that increase in response to stress. However, research on the adaptogenic effects of lion's mane is still in the early stages, and more studies in humans are needed.
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Safety of lion's mane mushroom nootropics
Lion's mane mushrooms are large, white, shaggy mushrooms that resemble a lion's mane. They are also known as Hericium erinaceus, hou tou gu, or yamabushitake. Native to North America, Europe, and Southeast Asia, they have been used in Asian countries like China, India, Japan, and Korea for their culinary and medicinal properties.
Lion's mane mushroom is a nootropic that has been shown to be a powerful catalyst for brain cell regeneration, improving memory and cognition. It contains two unique compounds, hericenones and erinacines, that can stimulate the growth of brain cells. Erinacines can easily cross the blood-brain barrier to boost neuron production and support nerve growth, which may help prevent and treat neurodegenerative diseases such as Alzheimer's, dementia, and Parkinson's.
While research has shown the potential benefits of lion's mane mushroom as a nootropic, it is important to consider safety. Generally, lion's mane mushroom supplements have been found to be safe and well-tolerated when taken in recommended doses. However, as with any supplement, there may be side effects, and certain populations may need to exercise caution.
For instance, while limited, some human studies have shown a positive impact on cognitive function and mood. A 2020 study found that 1 gram of lion's mane mushroom supplementation daily for 49 weeks significantly improved cognitive test scores in people with mild Alzheimer's disease compared to a placebo. Another study on healthy young adults showed improved reaction time on a Stroop task after a single dose and a trend towards reduced subjective stress after 28 days of supplementation.
However, it is important to consult a healthcare provider before taking lion's mane mushroom supplements, especially for those who are pregnant, breastfeeding, or have certain medical conditions. Additionally, as most adaptogen products contain multiple ingredients, it is crucial to check the labels and choose reputable manufacturers to ensure the safety and quality of the product.
Overall, while lion's mane mushroom nootropics have shown promising results in improving brain health and cognitive function, more comprehensive human studies are needed to fully understand their safety and effectiveness.
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Frequently asked questions
Nootropics, also known as "smart drugs", are a diverse group of substances that improve human thinking, learning, and memory. Mushroom nootropics are generally considered safe, but there is limited research on their long-term effects. It is important to consult a healthcare provider before consuming mushroom nootropics to ensure they are safe and appropriate for your needs.
Side effects of mushroom nootropics may include dizziness, headache, nausea, and severe allergic reactions. Some mushroom nootropics may also contain undisclosed ingredients, such as hallucinogenic substances, which can cause serious adverse effects.
Lion's mane, reishi, and cordyceps mushrooms are commonly used in nootropic supplements. These mushrooms are also used in traditional medicine, particularly in Asian countries.
Mushroom nootropics are marketed as cognitive enhancers and are claimed to improve memory, learning, and overall brain function. They are also believed to have immune-boosting and anti-inflammatory effects.
Mushroom nootropics should be avoided during pregnancy or breastfeeding. They may also interact with certain medications, such as blood-thinning or blood-pressure-lowering drugs. It is important to consult a healthcare provider to determine if mushroom nootropics are safe for your individual needs.

























