
Mushrooms are generally considered a low-histamine food, but some people experience side effects similar to histamine intolerance, such as nasal congestion, fatigue, headaches, or digestive problems. Histamine is a compound involved in immune responses, and while most people can tolerate foods high in histamines, approximately 1% of the population has an intolerance. Histamine levels vary across different types of mushrooms, and some contain histamine-like amines that may trigger symptoms. People with histamine intolerance should work with a healthcare provider to determine the types and amounts of mushrooms that can be included in their diet.
| Characteristics | Values |
|---|---|
| Are mushrooms high or low histamine? | Mushrooms are generally considered a low-histamine food and may be safe to include in a low-histamine diet. However, they do contain histamine-like amines that might lead to side effects similar to histamine intolerance, such as nasal congestion, fatigue, headaches, or digestive problems. |
| Types of mushrooms considered low histamine | Chaga mushrooms, Lion's mane mushroom, Agaricus blazei Murill mushroom, Shiitake, Reishi, Cordyceps, Cremini, White, Button, and Portobello mushrooms |
| Tips for including mushrooms in a low-histamine diet | Choose fresh mushrooms over canned, dried, and cooked forms. Store mushrooms in the refrigerator and toss them out as soon as they show signs of moulding, aging, or decay. Eat mushrooms raw when possible. If they must be cooked, braise or steam them instead of grilling to minimize histamine production. |
| Histamine intolerance | Approximately 1% of the population has a histamine intolerance. It tends to be more common in middle age. Histamine intolerance is not considered a food allergy. |
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What You'll Learn

Histamine intolerance
While the exact cause of histamine intolerance is unclear, certain medications and gut conditions can contribute to it. Additionally, low levels of diamine oxidase (DAO), the protein responsible for breaking down histamine, can be a factor. DAO deficiency can be caused by genetics, kidney disease, or liver disease.
Mushrooms are typically considered a low-histamine food and may be included in a low-histamine diet. However, they contain histamine-like amines that can lead to side effects similar to histamine intolerance, such as nasal congestion, fatigue, headaches, or digestive problems. To minimize histamine intake from mushrooms, it is recommended to choose fresh mushrooms over dried, canned, or cooked forms. Eating them raw is ideal, but if cooking is necessary, braising or steaming is preferable to grilling.
Individuals with histamine intolerance should work closely with a healthcare provider to determine their tolerance for mushrooms and develop a customized meal plan. They may also benefit from taking dietary supplements like copper, vitamin B6, and vitamin C to help manage histamine levels and any associated side effects.
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Cooking methods
Histamine is a chemical compound involved in immune responses and can cause symptoms like itching, sneezing, and even food intolerance in some people. Histamine intolerance is a rare condition, and it is estimated to affect about 1% of the population. While nearly all foods contain some histamine, certain foods are considered high-histamine foods, such as aged cheese and fermented foods. Mushrooms, on the other hand, are generally considered low-histamine foods, but they do contain histamine-like amines that might lead to side effects similar to histamine intolerance.
- Choose fresh mushrooms: The fresher the mushrooms, the lower the histamine levels. As mushrooms age, their histamine content can rise, so try to consume them as soon as possible after purchasing. Look for mushrooms with firm, plump caps and avoid any that appear slimy or decayed.
- Cook from raw: Avoid using pre-cooked, canned, dried, or frozen mushrooms as the histamine content rises with processing and storage time.
- Cook quickly: Quick cooking methods such as grilling, sautéing, or steaming are recommended over slow cooking or fermenting. Sautéing mushrooms in olive oil on high heat can help prevent significant histamine formation.
- Braising: Braising mushrooms is another suitable cooking method that minimizes histamine production.
It is important to note that individual sensitivity to histamine can vary, and some people may experience intolerance or allergic reactions to mushrooms. If you suspect histamine intolerance, it is advisable to consult a healthcare professional and consider keeping a food diary to track symptoms and identify potential triggers.
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Fresh vs dried
Histamine intolerance can lead to high histamine levels in the body because it doesn't break down histamine properly, which may cause bothersome symptoms. Adopting a low-histamine diet is one of the main strategies for managing histamine intolerance. This involves avoiding high-histamine foods, like fermented products, aged cheeses, and certain types of fish. Mushrooms are generally considered a low-histamine food, but they do contain histamine-like amines that might lead to side effects similar to histamine intolerance.
When it comes to fresh vs dried mushrooms, it is recommended to choose fresh mushrooms over dried, canned, or cooked forms to minimize histamine intake. Fresh mushrooms contain minimal histamine, making them suitable for people with histamine intolerance. However, as mushrooms age or become preserved, their histamine content can increase. Therefore, it is best to consume fresh mushrooms shortly after purchase and avoid dried or preserved varieties if you are sensitive to histamine.
The histamine content in mushrooms increases as they age after harvesting. So freshly cooked mushrooms typically contain less histamine than those that have been stored for prolonged periods. While mushrooms are not recommended in large amounts on a low-histamine diet, moderate portions of low-histamine varieties a few times per week are unlikely to cause issues for most people.
To minimize histamine formation, it is essential to keep mushrooms fresh, store them properly, and consume them quickly after purchase. Additionally, cooking mushrooms at home ensures they are prepared in a way that minimizes histamine content. Braising or steaming them instead of grilling can also help minimize histamine production.
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Safe types of mushrooms
Histamine intolerance occurs when the body cannot break down histamine correctly, leading to a buildup that may cause allergy-like symptoms. While nearly all foods contain some histamine, certain foods are known to be high in histamine or trigger histamine release. These include aged cheeses, fermented foods, processed meats, certain types of fish, alcohol, and some fruits.
Mushrooms are generally considered low-histamine foods, but they do contain histamine-like amines that might lead to side effects similar to histamine intolerance, such as nasal congestion, fatigue, headaches, or digestive problems. To minimize histamine intake when consuming mushrooms, choose fresh mushrooms over dried, canned, or cooked forms. Fresh mushrooms should be stored in the refrigerator and consumed within a few days to avoid spoilage, which can increase histamine levels. Cooking methods such as braising or steaming are preferred over grilling to minimize histamine production.
When it comes to specific types of mushrooms, button mushrooms, oyster mushrooms, and cremini mushrooms are generally considered safe for individuals with histamine intolerance. Shiitake mushrooms, on the other hand, are known to contain higher levels of histamine and may trigger symptoms in sensitive individuals. Reishi, cordyceps, white, and portobello mushrooms are other common types of edible mushrooms, but their histamine levels may vary.
It is important to note that individual responses to mushrooms can vary significantly. Some highly sensitive individuals may experience symptoms even with small amounts of histamine. If you notice any adverse reactions after consuming mushrooms, consider removing them from your diet temporarily and then gradually reintroducing them to determine your personal tolerance level. Working closely with a healthcare provider to develop a customized meal plan is essential for managing histamine intolerance effectively.
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Histamine testing
Histamine is a chemical released by the immune system in response to potential allergens. It is also involved in the body's immune response, gut function, and regulation of physiological processes. While histamine has several functions, it is typically known for causing allergy and anaphylactic symptoms.
Histamine intolerance occurs when the body can't break down histamine correctly, causing a build-up that may lead to allergy-like symptoms. This condition affects approximately 1% of the population and tends to be more common in middle-aged individuals. Those with histamine intolerance may experience symptoms such as coughing, wheezing, and watery eyes, nasal congestion, fatigue, headaches, or digestive problems.
To determine histamine intolerance, individuals can undergo allergy testing, which can help show whether their symptoms are caused by allergies. Here are some common histamine testing methods:
- Skin Prick Test: This involves pricking the skin with tiny drops of allergens or histamine to observe any reactions. A lack of reaction to histamine after 50 minutes may indicate difficulty in breaking down histamine.
- Blood Testing: Blood tests can reveal high histamine levels, low levels of DAO (diamine oxidase, an enzyme that breaks down histamine), or other irregularities.
- Colonoscopy: Doctors can check histamine and DAO levels in the colon during this procedure.
Individuals with histamine intolerance can work with healthcare providers to develop a low-histamine meal plan. While mushrooms are generally considered low-histamine foods, some types, such as shiitake and maitake mushrooms, have higher histamine content. Additionally, the histamine content in mushrooms increases as they age, so fresh mushrooms are preferable to dried, canned, or grilled varieties.
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Frequently asked questions
Mushrooms are generally considered a low-histamine food, but they do contain histamine-like amines that might lead to side effects similar to histamine intolerance. Histamine is a compound involved in immune responses, and too much of it can lead to coughing, wheezing, and watery eyes.
Symptoms of histamine intolerance include nasal congestion, fatigue, headaches, or digestive problems. People with histamine intolerance may also experience allergy-like symptoms such as itching, sneezing, and food intolerance.
Yes, while most mushrooms are low in histamine, studies suggest that certain types of mushrooms, such as dried Polish forest mushrooms, have higher histamine levels. Additionally, some mushrooms contain high levels of compounds like putrescine and spermidine, which can affect histamine levels in the body.
Individuals with histamine intolerance may react differently to mushrooms. While mushrooms are not considered high-histamine foods, they can trigger histamine-like responses in some people with histamine intolerance. It is important to work with a healthcare provider to determine the amount and type of mushrooms that can be included in a low-histamine meal plan.

























