
The use of psychedelics, including LSD and magic mushrooms, has long been a topic of fascination, with both substances offering unique experiences and gaining cultural significance. While there are similarities between the two, they can produce very different experiences, affecting the brain and body in distinct ways. Both substances are illegal and can lead to impaired judgment, serious injury, and even death in some cases. However, they have also shown promising results in the treatment of mental health disorders when used responsibly and with medical supervision. So, when comparing LSD and mushrooms, it's not just a matter of which is more spiritual but also understanding their individual effects, benefits, and risks.
| Characteristics | Values |
|---|---|
| How consumed | Mushrooms are usually dried, eaten or brewed into a tea. LSD is sometimes taken from a dropper but is more commonly applied to small tabs of paper that dissolve in the mouth. |
| Tolerance | It typically takes less LSD than psilocybin to produce psychedelic effects. |
| Duration | An LSD trip can last 8–12 hours, whereas a mushroom trip usually lasts 4–6 hours. |
| Safety | Both substances present few major risks, but there are some potential physical and psychological complications to be aware of. |
| Overdose | It is possible to overdose on LSD, although deaths are rare. |
| Natural/synthetic | Mushrooms are natural; LSD is synthetic. |
| Visual effects | LSD tends to produce more intense visual effects. |
| Emotional experiences | Mushrooms tend to induce deeper introspection and more emotional experiences. |
| Spiritual experiences | Mushrooms tend to produce a more spiritual experience. |
| Therapeutic potential | Both substances show promise in treating mental health disorders, but more research is needed. |
| Cultural significance | Mushrooms have a deep cultural significance due to their long history of use in indigenous cultures for spiritual and healing purposes. LSD became synonymous with the 1960s counterculture movement. |
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What You'll Learn

History of use
The history of the use of LSD and mushrooms differs greatly. LSD, or lysergic acid diethylamide, was first synthesized by Swiss scientist Albert Hofmann in 1938. He was working with a chemical found in ergot, a fungus that grows naturally on rye and other grains. Hofmann didn't discover the drug's hallucinogenic effects until 1943 when he accidentally ingested a small amount and experienced intense visuals. During the Cold War, the CIA conducted secret experiments with LSD for mind control, information gathering, and other purposes. LSD was also studied by psychiatrists and academics for its potential therapeutic benefits, with over 1,000 scientific papers published on the drug during this time. It was prescribed as a treatment to over 40,000 patients and was also used recreationally by many in the 1950s and 1960s, becoming a symbol of the counterculture movement.
The history of mushroom usage, on the other hand, goes back much further. Mushrooms have been used for centuries in religious and spiritual practices due to their ability to induce altered states of consciousness. The earliest recorded evidence of mushroom cultivation comes from China, where farmers grew shiitake mushrooms over 1,000 years ago, though the practice is thought to have started as early as 600 AD. During the 17th century, mushroom cultivation became popular in France and other parts of Europe, with French gardeners developing the technique of growing mushrooms in caves. In the United States, mushroom farming became popular in the early 20th century, brought over by European immigrants.
In the 1960s, the use of both LSD and mushrooms became widespread, with the Grateful Dead and Ken Kesey and the Merry Pranksters hosting "Acid Tests," free-form parties that introduced many people to LSD for the first time. Both substances were also administered to Harvard students during a series of experiments in the early 1960s by professors Timothy Leary and Richard Alpert. LSD and mushrooms have continued to capture the public imagination, featuring in movies, TV shows, and music. In recent years, there has been promising research on the potential therapeutic benefits of both substances for treating mental illnesses and addiction.
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Effects on the brain
The effects of LSD and magic mushrooms on the brain have been a topic of interest for researchers, with both substances offering unique experiences for users. Here are some insights into how these substances affect the brain:
Both LSD and magic mushrooms are classified as hallucinogens or psychedelics, which are known for their profound effects on perception, cognition, and consciousness. They interact with the brain's serotonin system, specifically by binding to or activating serotonin receptors. This interaction alters neural pathway activity and influences mood, perception, and consciousness. The activation of serotonin receptors reduces the energy required for the brain to switch between different activity states, potentially explaining the altered states of consciousness induced by these substances.
LSD (lysergic acid diethylamide) is known for its intense visual effects, including vivid hallucinations, altered perceptions of time and space, and shifts in self-awareness. These effects create a largely cerebral experience, with users reporting deep thought patterns and an increased sense of creativity. The side effects of LSD are unpredictable and can vary depending on the person, including mental and emotional changes, increased muscle tension, and muscular incoordination.
On the other hand, magic mushrooms, or "shrooms," are associated with a more grounded and emotionally charged experience. While they can also induce visual effects, users often report deeper introspection, profound emotional experiences, and a sense of connectedness to nature, others, and themselves. This sense of connection is often described as spiritual or mystical. Mushrooms have been used for centuries in indigenous cultures for spiritual and healing practices, contributing to their cultural significance.
It is important to note that the effects of these substances can vary significantly between individuals, and there is a risk of unpleasant trips involving paranoia or fear. Additionally, both LSD and mushrooms can lead to substance use disorder if not approached with caution and respect.
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Duration of trips
The duration of a trip depends on the substance consumed. A mushroom trip usually lasts up to 6 hours, whereas an LSD trip can continue for up to 10 hours or more.
The duration of a trip can vary from person to person. For example, the effects of shrooms typically last between 3 to 6 hours, but some people may feel the effects for longer. Similarly, the average acid trip can last anywhere from 6 to 15 hours, but most trips won't extend beyond 12 hours.
The duration of the trip also depends on various other factors. For shrooms, the time taken to kick in depends on how they are consumed. For instance, when consumed as tea, shrooms can kick in as fast as 5 to 10 minutes after ingestion. On the other hand, it takes about an hour for the effects of shrooms or LSD to kick in on an empty stomach. Consuming them after a meal can prolong this timeframe.
The amount of substance consumed also plays a role in the duration of the trip. For instance, larger doses of mushrooms can lead to unpredictable behaviour. Similarly, heavy doses of LSD can create intense highs that may make one uncomfortable or nauseous.
Lastly, the mindset and emotions, environment, and expectations of the user can also impact the duration of the trip. For instance, if the user is deeply introspective during the trip, it may seem longer. On the other hand, if they are distracted by talking with friends, music, or a movie, it may seem shorter.
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Intensity of trips
The intensity of a trip varies depending on the substance and the individual. While the effects of LSD and magic mushrooms are similar, they differ in intensity, duration, and nature.
LSD is known for its intense visual effects, including patterns, shapes, and altered perceptions of time and space. It can also lead to profound changes in thought processes, mood swings, and an increased sense of creativity. The effects of LSD tend to be longer-lasting than those of psilocybin, with trips sometimes lasting 8 to 12 hours, whereas psilocybin mushroom trips usually last 4 to 6 hours. The longer duration of LSD trips can result in more intense cerebral experiences, often involving deep thought patterns and vivid visual hallucinations.
Mushrooms, while also capable of producing visual effects, tend to induce a more introspective and emotionally charged experience. Users often report deep feelings of connection to nature, others, and themselves, along with increased empathy and a sense of spiritual or mystical connection. The emotional experiences associated with mushrooms are typically less erratic than those of LSD.
Combining mushrooms and LSD increases the intensity of each, which can be dangerous and increase the risk of serotonin syndrome.
The intensity of the trip also depends on individual factors such as mindset, environment, and dosage. It is important to be in the right frame of mind and a safe, peaceful environment when using hallucinogens. Additionally, the dosage of the substance can significantly impact the intensity of the trip.
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Therapeutic potential
While both LSD and magic mushrooms are psychedelic drugs, they differ in their sources, effects, and overall experiences. LSD is a synthetic, mind-altering chemical compound created in a laboratory, whereas magic mushrooms are natural and derived from certain species of mushrooms containing the psychoactive compound psilocybin.
There has been promising research on the therapeutic potential and comparative benefits of LSD and magic mushrooms in treating mental illnesses such as depression, PTSD, and addiction. Both substances are known to induce ego dissolution and a feeling of "mind expansion," which can lead to deeply philosophical or spiritual experiences. However, they differ in the nature of these experiences.
LSD is known for its intense thought patterns and ability to trigger profound changes in mood, cognition, and perception. It often leads to a more cerebral experience, with users reporting intense thought patterns, ego dissolution, and a feeling of "mind expansion." The effects of LSD can be unpredictable and vary depending on the person's experience with the drug. It can also affect the central nervous system, leading to increased monosynaptic reflexes, muscle tension, and muscular incoordination. These issues are rare but can become more likely with repeated use.
On the other hand, magic mushrooms tend to induce more emotional introspection, often leading to feelings of empathy, connectedness, and reflection on personal issues. There is often a sense of unity with nature or deep emotional insight. The emotional experiences associated with mushrooms are typically less erratic than those of LSD. Mushrooms produce more of a whole-body experience, with a "fluid" sense of reality. While excessive consumption of magic mushrooms can lead to negative side effects such as aggression, violence, and risky behavior, they have not been shown to cause extensive physical damage after use.
In terms of therapeutic potential, both substances have their unique benefits. LSD may be more suitable for individuals seeking a more cerebral and intense experience, while magic mushrooms could be preferred for those desiring a more emotional and introspective journey. Additionally, the natural origin of magic mushrooms and their shorter-acting effects may be preferable to some individuals. Ultimately, the suitability of each substance will depend on the individual's specific needs and preferences.
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Frequently asked questions
LSD is a synthetic substance derived from a fungus that grows on rye, while psilocybin mushrooms are natural and contain the naturally occurring compounds psilocybin and psilocin. LSD typically lasts longer than mushrooms, with trips lasting 8 to 12 hours compared to 4 to 6 hours for mushrooms. LSD tends to produce more intense visual effects and complex thought patterns, while mushrooms often lead to deeper introspection, emotional experiences, and a sense of spiritual connection.
Mushrooms have a long history of use in indigenous cultures for spiritual and healing purposes and are known to provide a calming, spiritual experience. Users often report feelings of connection to nature, others, and themselves, along with increased empathy and a sense of spiritual or mystical connection. While LSD can also lead to spiritual experiences, it is known more for its intense visual effects and mind-altering experiences.
Both substances are illegal and can cause impaired judgment, leading to serious injury, illness, and in rare cases, death. They can also lead to substance use disorder if not taken seriously. Additionally, there is a risk of having a ""bad trip""", which can involve paranoia or fear. While these effects typically wear off within 24 hours, some people may experience lingering distress.
Taking LSD and mushrooms together can increase the intensity of each, as well as the risk for serotonin syndrome. It is important to start with low doses of each and monitor their effects. Planning and set are key when combining these substances. It is also important to have a sober trip sitter present to ensure your safety.

























