
Histamine is a chemical released by the human immune system in response to potential allergens. While it has several functions, it is mostly known for causing allergy symptoms, some of which can become life-threatening. Histamine intolerance occurs when the body cannot break down histamine correctly, leading to a build-up in the body. Certain foods are high in histamine or may cause the body to release more histamine, and some people are advised to avoid mushrooms as part of a low-histamine diet. This is because histamine content in mushrooms can increase as they age, and cooking methods such as slow cooking or fermenting can increase histamine levels.
| Characteristics | Values |
|---|---|
| Histamine levels in mushrooms | Vary |
| High putrescine content in mushrooms | Could increase the adverse effects of histamine |
| High putrescine content in mushrooms | Could be the reason for mushroom consumption causing histamine intolerance symptoms in some people |
| Quick cooking methods | Less likely to increase histamine levels |
| Fresh mushrooms | Lower histamine levels |
| Fermentation | Significantly increases histamine levels |
| Histamine intolerance | Can be managed effectively but not cured |
| Histamine intolerance | Affects approximately 1% of the population |
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What You'll Learn

Histamine intolerance symptoms
- Runny nose
- Headaches
- Congestion
- Sneezing
- Hay fever
- Rashes
- Diarrhea
- Abdominal discomfort
- Gas
- Bloating
- Constipation
- Respiratory issues, such as rhinorrhea, rhinitis, nasal congestion, and dyspnea
The severity of symptoms can vary, and people who have allergies in addition to histamine intolerance may experience more serious allergic reactions. Histamine intolerance can also cause gastrointestinal symptoms, and studies have shown that histamine may play a role in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
If you suspect you have histamine intolerance, it is important to work with a healthcare professional to devise a personalized low-histamine diet plan and monitor your symptoms.
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Histamine levels in mushrooms
Histamine is a chemical released by the human body's immune system in response to potential allergens. It is also naturally present in some foods. While histamine has several functions, it is typically known for causing allergy and anaphylactic symptoms, some of which can become severe or life-threatening.
Some studies suggest that a high putrescine content in mushrooms could increase the adverse effects of histamine and be the reason mushroom consumption may cause histamine intolerance symptoms in some people. One study analyzed 53 processed and unprocessed mushrooms and found that spermidine and putrescine were the most common amides in mushrooms, while histamine was only present in high amounts in eight samples of dried Polish forest mushrooms.
People with histamine intolerance cannot break down histamine correctly, causing it to build up in the body. This can lead to allergy-like symptoms such as sneezing, itching, or hives. It is important to note that histamine intolerance is not considered a food allergy. Individuals with histamine intolerance should work with a healthcare provider to determine the amount and type of mushrooms to include in their diet and develop a customized meal plan.
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Low-histamine cooking methods
Histamine intolerance can lead to high histamine levels in the body and cause allergy symptoms, headaches, or an upset stomach. While histamine levels in mushrooms vary, studies suggest that a high putrescine content in mushrooms could increase the adverse effects of histamine.
- Choose fresh mushrooms over dried, processed, or fermented mushrooms, as histamine levels can increase with age and during the fermentation process.
- Cook mushrooms quickly: grilling, sautéing, steaming, boiling, or baking at low to medium temperatures are recommended.
- Avoid slow cooking or marinating meat.
- Use a pressure cooker for tougher cuts of meat.
- Avoid browning or burning food.
- Freeze leftovers immediately to prevent histamine-triggering bacteria from forming.
- Avoid non-stick cookware, opting instead for stainless steel, ceramic-coated, or enameled pots and pans.
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Histamine levels and storage
Histamine intolerance occurs when the body has high levels of histamine. This can happen if the body cannot break down histamine properly, leading to symptoms like headaches, nasal congestion, digestive issues, and irregular periods. To manage histamine intolerance, individuals may need to identify and avoid foods high in histamine or those that trigger histamine release.
Fresh mushrooms are recommended for those on a low-histamine diet, as histamine levels can increase as mushrooms age. Quick cooking methods, such as grilling or sautéing, can also help prevent significant histamine formation.
If you are not consuming mushrooms immediately, it is best to store them in a cool, dry place or refrigerate them to slow down histamine production. Proper storage is crucial, as improper storage or leaving mushrooms at room temperature for extended periods can increase histamine levels due to bacterial activity.
Additionally, individuals with histamine intolerance should generally avoid processed, aged, dried, canned, very ripe, and fermented foods, as these tend to have higher histamine levels. Working closely with a healthcare provider is essential to determine a safe and suitable low-histamine meal plan.
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Histamine-intolerant meal plans
Histamine intolerance occurs when the body struggles to break down histamine, a chemical produced by the body that is also found in certain foods. Histamine intolerance can lead to high histamine levels in the body, causing a range of symptoms, including allergy symptoms, headaches, skin irritation, or an upset stomach.
A low-histamine diet can be an effective management strategy for histamine intolerance. This involves identifying and avoiding foods high in histamine or those that trigger histamine release. An elimination diet may be suggested by a medical professional to help diagnose histamine intolerance and identify individual triggers.
- Choose fresh, whole foods whenever possible. Fresh foods generally contain lower levels of histamine.
- Avoid processed, aged, dried, canned, very ripe, and fermented foods. Histamine levels can increase as foods age, so consuming fresh foods is best.
- Quick cooking methods, such as grilling or sautéing, are preferable to slow cooking as they prevent significant histamine formation.
- If you are not consuming mushrooms immediately, store them in a cool, dry place or refrigerate them to slow down histamine production.
- Keep a food diary to track symptoms and identify potential triggers, allowing you to adjust your diet accordingly.
- Work closely with a healthcare provider to determine the amount and type of mushrooms that are safe to include in your meal plan.
- Consult your doctor about taking antihistamine medications or altering your medication regimen if you are currently on any.
- Consider taking dietary supplements, such as copper, vitamin B6, and vitamin C, to help manage histamine levels and any side effects.
It is important to note that a low-histamine diet is a temporary solution, and addressing the root causes of histamine intolerance is crucial for long-term relief. Additionally, an individualized approach is essential as tolerance levels and triggers can vary from person to person.
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Frequently asked questions
Histamine is a chemical released by the immune system in response to potential allergens. It is known for its role in contributing to allergy symptoms. Histamine also has other important functions, such as regulating sleep-wake cycles and cognitive function.
Histamine intolerance occurs when the body cannot break down histamine correctly, causing a build-up in the body. This can lead to allergy-like symptoms such as sneezing, itching, hives, coughing, wheezing, and watery eyes. It is not considered a food allergy. Approximately 1% of the population has histamine intolerance.
Histamine levels in mushrooms vary. Fresh mushrooms contain relatively low levels of histamine. However, histamine levels can increase as mushrooms age or if they are stored incorrectly. Quick cooking methods such as grilling or sautéing can help prevent a significant increase in histamine levels.
If you suspect you have histamine intolerance, consult a healthcare professional. They can help you devise a personalized low-histamine diet plan and monitor your symptoms. A low-histamine diet may involve avoiding high-histamine foods, choosing fresh whole foods, and quick cooking methods.

























