
Adderall is a prescription drug used to treat conditions like ADHD and narcolepsy. It is a combination of amphetamine and dextroamphetamine, which stimulates the central nervous system. On the other hand, magic mushrooms, or psilocybin, have shown promise in treating depression, addiction, and other mental health issues. However, they can interact negatively with other drugs, especially stimulants like Adderall, and other hallucinogens. Mixing Adderall and magic mushrooms can lead to cardiovascular issues, anxiety, and unpredictable psychological effects. There is limited research on the topic, but initial findings suggest potential health risks associated with combining these substances.
| Characteristics | Values |
|---|---|
| Safety | There is scarce research on the effects of mixing mushrooms and Adderall. However, Adderall is known to interact with alcohol, other medications, and some supplements. |
| Health Risks | Mushrooms have a low risk profile when taken alone. However, when combined with Adderall, there are risks of cardiovascular strain and unpredictable psychological effects. |
| Interactions with Other Substances | Mushrooms should not be taken with stimulants, depressants, or other substances as it can increase the risk of accidents, injuries, and fatal serotonin syndrome. Adderall may also interact with alcohol and other medications. |
| Precautions | Discuss any medications, vitamins, supplements, and herbs with your doctor and pharmacist before taking Adderall. Allow an integration period after a psychedelic trip before taking Adderall. |
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What You'll Learn

Adderall is a stimulant
Stimulants like Adderall speed up breathing, and shortness of breath or faster-than-usual breathing can be a warning sign of a drug overdose. Furthermore, psilocybin mushrooms interact particularly badly with stimulants as both can increase heart rate and blood pressure, leading to cardiovascular strain. Mixing mushrooms with other substances, whether illicit or prescribed, is also generally more dangerous. This includes antidepressants, as the combination could lead to fatal serotonin syndrome.
There is scarce research evaluating the effects of mixing mushrooms with Adderall, but it is known that taking Adderall after a psychedelic experience may affect the results, particularly during the afterglow period. Therefore, it is best to allow an integration period before taking other substances, and one's physical and mental well-being should be prioritised when considering any substance use. Before starting treatment with Adderall, it is important to discuss alcohol consumption, medication use, and any vitamins, supplements, and herbs with a doctor and pharmacist to avoid potential interactions.
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Mushrooms are a psychedelic
Mushrooms, specifically psilocybin mushrooms, are a psychedelic substance. They are sometimes referred to as "magic mushrooms". When taken alone, they are considered to be the safest of all recreational drugs, with the greatest risk being a "bad trip", a time-limited experience of anxiety and paranoia. However, when combined with other substances, they can become significantly more dangerous. For example, mushrooms interact badly with stimulants, as both can increase heart rate and blood pressure. Mixing mushrooms with depressants like alcohol and opioids can increase the risk of accidents and injuries.
There is limited data on medication interactions with psychedelics, but studies suggest that classic serotonergic psychedelics such as LSD and synthetic psilocybin should not produce a hypertensive emergency when combined with MAOIs. However, one case study suggests that phenylethylamine, found in Psilocybe cubensis and other psilocybin mushrooms, may have interacted with tranylcypromine and dextroamphetamine-amphetamine to produce a hypertensive emergency. As Adderall is a prescription drug that contains dextroamphetamine-amphetamine, it may have similar interactions with psilocybin mushrooms and should be approached with caution.
It is important to note that Adderall may also interact with alcohol, other medications, and some supplements. Patients prescribed Adderall are advised to avoid alcohol, as the side effects could be dangerous. Similarly, those taking psilocybin mushrooms should refrain from consuming any other substances that act on serotonin, such as other hallucinogens and antidepressants, as this could lead to serotonin syndrome, which can be fatal.
In conclusion, while there may not be any reported interactions between Adderall and the mushroom supplement lion's mane, it is generally advised to avoid mixing Adderall and psilocybin mushrooms due to potential cardiovascular strain and unpredictable psychological effects. It is always crucial to prioritize mental and physical well-being when considering any substance use.
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Mixing mushrooms with Adderall may cause cardiovascular strain
There is limited data on the interaction between Adderall and magic mushrooms, but some reports suggest that it can cause severe hypertension, chest pain, palpitations, and headaches. In one case, a 42-year-old man with treatment-resistant major depressive disorder took Psilocybe cubensis mushrooms while also taking a monoamine oxidase inhibitor (MAOI) and extended-release dextroamphetamine-amphetamine (Adderall). He developed severe hypertension and other concerning symptoms.
While magic mushrooms on their own have a relatively low risk profile, with only 0.2% of 12,000 surveyed users requiring emergency medical treatment, mixing them with other substances can be dangerous. This includes both illicit and prescribed drugs, as well as alcohol. The combination of magic mushrooms and Adderall may lead to unpredictable psychological effects and physical side effects, such as cardiovascular strain.
It is important to prioritize mental and physical well-being when considering substance use. If you are taking Adderall or other medications, it is crucial to discuss any other substances you use with your doctor and pharmacist. They can provide guidance on potential interactions and help you avoid adverse effects. It is generally recommended to allow an integration period after a psychedelic trip before taking other substances.
In summary, mixing mushrooms with Adderall may cause cardiovascular strain due to the stimulating effects of both substances on the heart rate and blood pressure. Limited data suggests that this combination can lead to severe hypertension and other concerning symptoms. It is important to exercise caution and seek professional advice when considering the use of multiple substances.
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Combining mushrooms with Adderall may lead to unpredictable psychological effects
While there is limited data on the interaction between Adderall and mushrooms, combining the two substances may lead to unpredictable psychological effects.
Adderall, a prescription drug used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy, can interact with other medications, alcohol, and supplements. It is a stimulant that speeds up breathing and can cause cardiovascular strain when mixed with psychedelics like mushrooms. Mushrooms, or "shrooms," are also a psychedelic substance, and it is generally advised to not mix them with any other drugs.
Magic mushrooms, when taken on their own, have the lowest risk profile of any recreational drug. However, when combined with other substances, the risks increase significantly. Mixing mushrooms with stimulants like Adderall can increase heart rate and blood pressure, leading to cardiovascular strain. Additionally, the combination of mushrooms and Adderall may result in unpredictable psychological effects, which could include anxiety and paranoia.
In one reported case, a 42-year-old man with treatment-resistant major depressive disorder experienced severe hypertension, chest pain, palpitations, and a headache after consuming Psilocybe cubensis mushrooms while also taking prescribed extended-release dextroamphetamine-amphetamine (Adderall) and other medications. It is suspected that phenylethylamine, found in certain species of psilocybin mushrooms, interacted with the dextroamphetamine-amphetamine to produce this hypertensive emergency.
It is crucial to prioritize mental and physical well-being when considering substance use. If you are taking Adderall or planning to take mushrooms, it is important to consult with a doctor or a healthcare professional to discuss potential interactions and risks.
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There is scarce research on mixing mushrooms with Adderall
While there is some information available on the effects of mixing mushrooms with Adderall, there is scarce research on this topic. Mixing mushrooms with Adderall or other stimulants carries real risks, from cardiovascular strain to unpredictable psychological effects.
Adderall (amphetamine/dextroamphetamine) is a prescription drug used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It can interact with alcohol, other medications, and some supplements. When prescribed Adderall, patients are advised not to consume alcohol as the side effects could be dangerous.
Magic mushrooms are also known to interact negatively with other substances, including illicit and prescription drugs. They interact particularly badly with stimulants, as both can increase heart rate and blood pressure. Combining mushrooms with depressants like alcohol and opioids can increase the risk of accidents and injuries.
There is limited data on medication interactions with psychedelics. However, one report details a hypertensive emergency following the combination of psilocybin mushrooms with a monoamine oxidase inhibitor (MAOI) and extended-release dextroamphetamine-amphetamine. The patient, a 42-year-old man with treatment-resistant major depressive disorder, experienced severe hypertension with chest pain, palpitations, and a headache.
It is important to prioritize mental and physical well-being when considering any substance use. Before starting treatment with Adderall, it is recommended to discuss alcohol consumption, medication use, and any vitamins, supplements, and herbs with a doctor and pharmacist.
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Frequently asked questions
No, it is not safe to mix mushrooms and Adderall. Mushrooms, or "shrooms", are a psychedelic and are not meant to be taken with any other drugs. Mixing psilocybin with stimulants or depressants carries real risks, from cardiovascular strain with Adderall to unpredictable psychological effects with alcohol.
The combination of mushrooms and Adderall can lead to cardiovascular strain and unpredictable psychological effects. A study reported that a 42-year-old man developed severe hypertension with chest pain, palpitations, and a headache after consuming mushrooms and Adderall together.
There are no reported interactions between Adderall and the mushroom supplement lion's mane. However, it is important to consult with a doctor or pharmacist before starting any new treatment or supplement.
Mixing mushrooms with other substances, including alcohol, opioids, and antidepressants, can increase the risk of accidents, injuries, and serotonin syndrome, which can be fatal. Mushrooms should also not be mixed with other hallucinogens as this can lead to a "bad trip" characterised by anxiety and paranoia.
Adderall is a stimulant that speeds up breathing. Mixing Adderall with alcohol can be dangerous and lead to more severe side effects. It is advised to not drink alcohol when prescribed Adderall.

























