
Magic mushrooms, or psilocybin, are a group of psychedelic drugs that have been used for thousands of years in spiritual and religious rituals. They have the potential to induce hallucinations and alter a person's sense of reality, perception, and cognition. Recent studies have explored the therapeutic potential of psilocybin in treating mental illnesses and substance use disorders. While the drug can cause adverse effects and risks, it has shown promising results in alleviating emotional distress and promoting positive life changes. It is important to note that the use of psilocybin should be supervised by trained experts due to potential dangers.
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What You'll Learn
- Magic mushrooms can bring about lasting personality changes
- Mushrooms have been used in religious rituals for thousands of years
- Psilocybin disrupts brain networks involved in creating a person's sense of self
- Mushrooms may be used to treat mental illnesses such as depression and PTSD
- Mushrooms can cause a person to see, hear and feel things that are not real

Magic mushrooms can bring about lasting personality changes
Magic mushrooms, or psilocybin, have been used in religious rituals for thousands of years. Ancient murals in Spain and Algeria suggest their usage around 4,000 BC, and they were called "teonanacatl" or "God flesh" in the Aztec language.
Today, magic mushrooms are known to induce hallucinations, relaxation, and changes in perception and cognition. They can also lead to an altered sense of time, spiritual experiences, and perceptual distortions. Researchers have found that psilocybin disrupts brain networks involved in creating a person's sense of self, resulting in acute changes in how they perceive time, space, and themselves.
While most brain activity returns to normal within days, some changes can be long-lasting. A study by Johns Hopkins University School of Medicine found that individuals who had mystical experiences while on psilocybin exhibited lasting personality changes, making them more open about their feelings and focused on creativity, curiosity, and appreciation for artistic things. This was reflected in the brain's functional connectivity, with significant changes observed throughout the cerebral cortex, thalamus, hippocampus, and cerebellum.
The potential therapeutic effects of psilocybin are also being explored. Research suggests it may help alleviate anxiety, depression, and distress related to end-of-life, with positive life changes attributed to its use. However, it is important to note that psilocybin should not be self-medicated due to serious risks, and its usage must be supervised by trained mental health experts.
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Mushrooms have been used in religious rituals for thousands of years
Magic mushrooms, or shrooms, have been used in religious rituals for thousands of years. They are known to produce psychedelic effects, altering perception and cognition. The active compound in magic mushrooms is psilocybin, which causes profound changes in brain activity patterns.
Ancient History
Psilocybin mushrooms have a long history of use in various ancient cultures and religions. Archaeological evidence suggests that these mushrooms were consumed by our prehistoric ancestors. Ancient paintings in Spain and murals in Algeria, dated to around 4000 BC and 7000-9000 BC, respectively, provide evidence of their use in religious ceremonies.
In Mesoamerica, psilocybe mushrooms were used ritually, therapeutically, divinatorily, and for pleasure. The Mixtec and Nahua cultures, including the Aztecs, considered these mushrooms sacred, referring to them as "teonanacatl" or "flesh of the gods." Mayan archives also indicate the common usage of psilocybin mushrooms in their ceremonies and rituals.
Modern Religious Use
In modern times, magic mushrooms have been adopted as a sacrament in some religions. They have been used by atheists, agnostics, and those who identify as "spiritual but not religious." The renewed interest in psychedelics has led to a psychedelic renaissance, with ongoing research exploring their therapeutic potential in treating conditions such as depression, anxiety, and PTSD.
Effects on the Brain
Psilocybin disrupts the brain network involved in creating a person's sense of self, leading to acute changes in how individuals perceive time, space, and themselves. It primarily affects the prefrontal cortex, influencing abstract thinking, thought analysis, mood, and perception. These effects can result in spiritual experiences, perceptual distortions, and enhanced creativity and curiosity.
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Psilocybin disrupts brain networks involved in creating a person's sense of self
Psilocybin, the active compound in magic mushrooms, has been found to disrupt brain networks involved in creating a person's sense of self. This disruption is believed to be responsible for the drug's mind-altering effects and its potential therapeutic benefits.
Research has shown that psilocybin causes profound changes in brain activity patterns, particularly in regions associated with self-reflection and the sense of self. These changes can lead to a distorted sense of time, space, and self, resulting in a psychedelic experience.
One study by Dr. Joshua Siegel and his team at Washington University in St. Louis used functional magnetic resonance imaging (fMRI) to track changes in brain activity related to psilocybin use. They found that psilocybin caused major changes in functional connectivity throughout the brain, including the cerebral cortex, thalamus, hippocampus, and cerebellum. These changes were significantly greater than those caused by a control compound.
The disruption of the default mode network, which is typically active during self-reflection, is of particular interest. This desynchronization may lead to a reduced focus on the self and an increased sense of openness and connectedness to the world. This effect could potentially contribute to the therapeutic benefits of psilocybin in treating mental health conditions such as depression, anxiety, and substance use disorders.
While the acute effects of psilocybin wear off within days, some changes in brain activity patterns have been found to persist for at least three weeks. These lasting changes may reflect alterations in hippocampus circuits involved in the perception of self. Researchers caution against self-medication with psilocybin due to potential risks, emphasizing the importance of supervision by trained mental health professionals.
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Mushrooms may be used to treat mental illnesses such as depression and PTSD
Magic mushrooms, or mushrooms containing the psychedelic drug psilocybin, have been found to produce changes in the brain that may be useful in treating mental illnesses such as depression and PTSD.
Psilocybin has been found to temporarily disrupt brain networks involved in creating a person's sense of self, resulting in acute changes in how people perceive time, space, and themselves. These changes may be beneficial in relieving symptoms of mental health disorders. For example, in the case of depression, psilocybin has been found to "flatten" the brain's landscape, reducing the rigidity associated with negative thought patterns and allowing for new thoughts and perspectives to emerge. This effect has been observed in brain scans of individuals who underwent psilocybin treatment, with reduced connections within brain areas associated with depression and increased connections to other regions of the brain. These changes were also associated with improvements in cognitive functioning and emotional processing.
Research has shown that psilocybin treatment can produce large decreases in depression severity, with effects lasting up to a year for most patients. In one study, participants with a long-term history of depression showed significant improvements after receiving two doses of psilocybin, with stable rates of response and remission throughout the follow-up period. However, it is important to note that these treatments were conducted under carefully controlled conditions with structured support from trained clinicians and therapists.
In addition to depression, psilocybin-assisted psychotherapy (PAP) has shown potential in treating post-traumatic stress disorder (PTSD). PAP has been found to facilitate the confrontation of traumatic memories, reduce emotional avoidance, and improve symptoms of depression, anxiety, and disconnection from others, all of which are relevant to PTSD recovery. Clinical trials are currently underway to further investigate the potential of psilocybin in treating PTSD.
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Mushrooms can cause a person to see, hear and feel things that are not real
Magic mushrooms, or shrooms, have been used for thousands of years in religious rituals. They are known to induce hallucinations and distort a person's sense of reality, making them see, hear, and feel things that are not real.
The active compound in magic mushrooms is psilocybin, which is a psychedelic drug that alters perception and cognition. When consumed, psilocybin is converted into psilocin by the body. Psilocin binds to serotonin receptors in the brain, specifically the 5-HT2A receptor, which affects brain function and communication between different brain regions. This results in a profound change in consciousness, with some regions of the brain becoming more active and connected while others decrease in activity.
The effects of psilocybin on the brain have been visualized through functional magnetic resonance imaging (fMRI) studies. These studies have shown that psilocybin causes major changes in functional connectivity, or FC, throughout the brain, including in the cerebral cortex, thalamus, hippocampus, and cerebellum. These changes are reflected in heat maps of brain activity, which show a profound disturbance during an individual's experience on psilocybin.
The disruption caused by psilocybin affects a person's sense of self, space, and time. It can lead to spiritual experiences, perceptual distortions, and altered thinking processes. Some people report seeing sounds or hearing colours, while others experience emotional journeys that help them gain new perspectives on their anxieties and insecurities. However, it is important to note that psilocybin can also cause negative experiences, such as anxiety, agitation, confusion, and physical side effects like nausea and vomiting.
While magic mushrooms can induce these temporary changes in perception and consciousness, they have also been found to bring about more lasting changes in personality and mental health. Researchers have suggested that the disruption of the default mode network, which is involved in self-reflection, may lead to increased openness and connectedness to the world, resulting in long-term personality changes. Additionally, psilocybin has shown promising results in clinical trials for treating mental health conditions such as anxiety, depression, and substance use disorders.
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Frequently asked questions
Magic mushrooms are a group of drugs called psychedelics or hallucinogens that have the potential to change a person's sense of reality. Psilocybin is the active compound in magic mushrooms.
When a person takes psilocybin, their body converts it to another substance, psilocin. Psilocin attaches to and activates receptors for the brain chemical serotonin. Psilocin activity at the 5HT2a receptor affects how the brain works and how different brain regions communicate with each other. These altered patterns of brain activity contribute to a person's profound change in consciousness.
The effects of magic mushrooms vary from person to person. Some people experience an altered sense of time, spiritual experiences, perceptual distortions, and changes in thinking processes. Some people also report feeling more open about their feelings and more focused on being creative, curious, and appreciative of artistic things.

























