
Histamine is a natural chemical that helps your cells communicate and is released by the immune system in response to potential allergens. Histamine intolerance can lead to high histamine levels in the body because it doesn't break down histamine properly, causing symptoms like coughing, wheezing, watery eyes, headaches, nasal congestion, fatigue, and gastrointestinal disturbances. While histamine levels in mushrooms vary, they are generally considered low-histamine foods. However, they do contain histamine-like amines that might lead to side effects similar to histamine intolerance. Therefore, individuals with histamine intolerance should work with a healthcare provider to determine the amount and type of mushrooms to include in their diet.
| Characteristics | Values |
|---|---|
| Are mushrooms high in histamine? | Most edible mushrooms are low in histamine but are a source of histamine-like amines like putrescine and spermidine. |
| What is histamine? | Histamine is a chemical released by the immune system known for its role in contributing to allergy symptoms. |
| What are the symptoms of histamine intolerance? | Side effects such as headaches, nasal congestion, fatigue, and gastrointestinal disturbances. |
| How to manage histamine intolerance? | Routine lab testing helps determine how well histamine intolerance is being managed. Individuals should work closely with a healthcare provider to determine the amount and type of mushrooms that are okay to include in a low-histamine meal plan. |
| Practical tips for including mushrooms in a low-histamine diet | Choose fresh mushrooms over canned, dried, and cooked forms. Eat mushrooms raw when possible. If they must be cooked, braise or steam them instead of grilling to minimize histamine production. |
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What You'll Learn

Histamine intolerance symptoms
Histamine intolerance occurs when the body cannot break down histamine correctly, causing it to build up in the body. This is often due to a deficiency in the DAO enzyme, which helps control and protect against high levels of histamine ingested through food. This deficiency can be caused by genetic, pathological, or pharmacological factors.
Histamine intolerance can cause a range of gastrointestinal symptoms, including bloating, abdominal discomfort, gas, diarrhoea or constipation, and other related issues. As histamine receptors are present across the body, symptoms can also manifest in other ways, such as respiratory issues including rhinorrhea, rhinitis, nasal congestion, dyspnea, and sneezing. In severe cases, histamine intolerance could lead to a dangerous condition called anaphylaxis.
Some people may associate eating mushrooms with histamine intolerance side effects and choose to avoid them. While histamine levels in mushrooms vary, studies suggest that a high putrescine content in mushrooms could increase the adverse effects of histamine. Most edible mushrooms are low in histamine but are a source of histamine-like amines like putrescine, which could potentially lead to symptoms in people with histamine intolerance. These symptoms include headaches, nasal congestion, fatigue, and gastrointestinal disturbances.
If you suspect you have histamine intolerance, it is important to talk to your doctor. They may recommend keeping a food diary to help identify patterns and determine if a certain food is causing your symptoms. They may also suggest avoiding all high-histamine foods for a few weeks and then slowly reintroducing them one at a time to identify any triggers.
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Histamine levels in mushrooms vary
Histamine is a chemical released by the immune system in response to potential allergens. It is best known for its role in allergies, causing symptoms such as coughing, wheezing, and watery eyes. Histamine intolerance occurs when the body does not break down histamine properly, leading to high histamine levels and bothersome symptoms. While histamine levels in mushrooms vary, they are generally considered a low-histamine food. Most edible mushrooms are low in histamine but contain histamine-like amines, such as putrescine and spermidine, which can lead to symptoms similar to histamine intolerance in some individuals.
The variation in histamine levels in mushrooms may be influenced by factors such as preparation techniques and storage methods. Fresh mushrooms are typically recommended over canned, dried, or cooked forms to minimize histamine content. Proper storage in the refrigerator and prompt disposal of molding or decaying mushrooms are crucial to prevent bacteria production and the potential increase in histamine levels.
Studies suggest that the high putrescine content in mushrooms could enhance the adverse effects of histamine. This may explain why some people associate mushroom consumption with histamine intolerance symptoms. One study analyzed 53 processed and unprocessed mushrooms and found that histamine was only present in high amounts in eight samples of dried Polish forest mushrooms. Another study examining histamine and other biogenic amine content in various foods detected no significant amounts of histamine in mushrooms but did find the presence of putrescine, spermidine, and small amounts of spermine.
It is important to note that individual responses to mushroom consumption can vary significantly among those with histamine intolerance. Some people may experience side effects such as headaches, nasal congestion, fatigue, and gastrointestinal issues after eating mushrooms. Individuals with histamine intolerance should work closely with healthcare professionals to determine the types and amounts of mushrooms that can be safely included in their diet. Keeping a food diary and consulting with a doctor can help identify patterns and triggers associated with histamine intolerance symptoms.
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Histamine-like amines in mushrooms
Histamine is a chemical released by the immune system in response to potential allergens. It is best known for its role in allergies, causing symptoms such as coughing, wheezing, and watery eyes. Histamine intolerance occurs when the body does not break down histamine properly, leading to high histamine levels and bothersome symptoms. While histamine levels in mushrooms vary, they are generally considered low-histamine foods. However, mushrooms contain histamine-like amines, including putrescine and spermidine, that can trigger histamine intolerance symptoms in some individuals.
The presence of histamine-like amines in mushrooms can lead to symptoms similar to histamine intolerance, such as nasal congestion, fatigue, headaches, and gastrointestinal issues. The variability in responses to mushroom consumption is notable, and individuals with histamine intolerance should determine their tolerance levels in consultation with a healthcare provider. Practical tips for including mushrooms in a low-histamine diet include choosing fresh mushrooms, storing them properly, and consuming them raw or minimally cooked.
Studies suggest that the high putrescine content in mushrooms may increase the adverse effects of histamine, providing a possible explanation for why some people associate mushroom consumption with histamine intolerance symptoms. Additionally, a study analyzing 53 mushroom samples found that spermidine and putrescine were the most common amides, with histamine present in high amounts only in a few samples of dried Polish forest mushrooms.
To manage histamine intolerance, individuals can follow a low-histamine diet, which involves avoiding high-histamine foods and gradually reintroducing them to assess tolerance. A food diary can be a helpful tool to identify patterns and trigger foods. While most edible mushrooms are low in histamine, they can still be a source of histamine-like amines, and individuals with histamine intolerance should monitor their consumption accordingly.
It is important to note that histamine levels in foods can vary, and factors such as medication, stress, and overall health can influence an individual's response to histamine. Consulting with a healthcare professional is essential to determine a safe and suitable diet that meets all nutritional needs.
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Side effects of eating mushrooms
Mushrooms are a good source of potassium and antioxidants, and they may even help prevent cancer. However, they can also cause several side effects, especially if consumed in high quantities or by individuals with histamine intolerance.
Mushrooms are generally considered low-histamine foods, but they do contain histamine-like amines such as putrescine, spermidine, and spermine. These amines can lead to side effects similar to histamine intolerance, including headaches, nasal congestion, fatigue, and gastrointestinal disturbances. Histamine intolerance occurs when the body does not break down histamine properly, resulting in high histamine levels and bothersome symptoms. While histamine is naturally produced by the body and plays a role in immune responses and cognitive function, it is also well-known for causing allergy symptoms when released in response to allergens.
The side effects of eating mushrooms can vary depending on the type and amount consumed, as well as individual tolerance levels. Some people may experience no side effects at all, while others may have adverse reactions. It is important to note that cooking mushrooms, especially through methods like grilling, can increase histamine levels, so consuming raw or lightly cooked mushrooms may be preferable for those with histamine intolerance.
In addition to histamine-related side effects, mushrooms can also cause poisoning if consumed in their wild, poisonous form. Symptoms of mushroom poisoning include nausea, vomiting, cramping, diarrhea, excessive salivation, sweating, tears, confusion, delusions, convulsions, and even organ damage or failure, which can be fatal. "Magic mushrooms," which contain the hallucinogenic substances psilocybin and psilocin, can lead to "bad trips," causing anxiety, hallucinations, and potentially dangerous behavior. It is crucial to only consume mushrooms purchased from reputable sources, as wild mushrooms can be poisonous or even deadly.
Overall, while mushrooms offer various nutritional benefits, it is important to be mindful of potential side effects, especially for individuals with histamine intolerance or when consuming wild mushrooms.
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Tips for including mushrooms in a low-histamine diet
Histamine is a chemical that occurs naturally in the body and in some foods. Histamine intolerance can lead to high histamine levels in the body because it doesn't break down histamine properly, which may cause bothersome symptoms. While histamine levels in mushrooms vary, studies suggest that a high putrescine content in mushrooms could increase the adverse effects of histamine and be the reason mushroom consumption may cause histamine intolerance symptoms in some people. Here are some tips for including mushrooms in a low-histamine diet:
- Choose fresh mushrooms over canned, dried, and cooked forms. Fresh mushrooms, especially those recently harvested, typically contain less histamine compared to those that have been stored for prolonged periods.
- To minimize bacteria production, store mushrooms in the refrigerator and throw them out as soon as they show signs of moulding, ageing, or decay.
- Eat mushrooms raw when possible. If they must be cooked, braise or steam them instead of grilling to minimize histamine production.
- Cook at home when possible. Cooking mushrooms at home ensures they are prepared in a way that minimizes histamine content.
- Opt for low-histamine mushrooms such as white button, cremini, and portobello mushrooms.
- Work closely with a healthcare provider to determine the amount and type of mushrooms that are okay to include in a low-histamine meal plan.
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Frequently asked questions
Mushrooms are generally considered a low-histamine food, but they do contain histamine-like amines that might lead to side effects similar to histamine intolerance. Histamine levels in mushrooms vary, with some varieties having negligible amounts and some containing modest amounts.
Symptoms of histamine intolerance include coughing, wheezing, watery eyes, sneezing, itching, redness, nasal congestion, fatigue, headaches, and gastrointestinal disturbances.
High-histamine foods include fermented products, aged cheeses, and certain types of fish.

























