
Active Hexose Correlated Compound (AHCC) is a supplement derived from the mycelia of shiitake (Lentinus edodes) mushrooms. AHCC is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects. The supplement is used to prevent and treat cancer, improve immune responses, and protect against oxidative stress-induced disorders. While AHCC has been studied for its potential health benefits, there is insufficient research to confirm its effectiveness, particularly as a treatment for cancer. It is important to consult a healthcare professional before taking AHCC or any other supplement to ensure it is appropriate and safe for individual needs.
| Characteristics | Values |
|---|---|
| What is it? | Active Hexose Correlated Compound (AHCC) |
| What is it derived from? | Cultured mushroom mycelia, specifically shiitake (Lentinus edodes) mushrooms |
| What does it contain? | Mixture of nutrients including oligosaccharides, amino acids, and minerals |
| How does it work? | Believed to act as an immune modulator, binding to TLR-2 and TLR-4 and producing cytokines |
| What is it used for? | Boosting immunity, preventing and treating cancer, treating HPV, liver disease |
| Dosage | Daily doses are typically between 1 and 3 grams |
| Side effects | May cause hypersensitivity reactions, not recommended during pregnancy or breastfeeding due to lack of data |
| Interactions | May interact with cancer medications and other drugs broken down by the liver |
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What You'll Learn

AHCC is an extract from shiitake mushrooms
AHCC (Active Hexose Correlated Compound) is a proprietary extract derived from the mycelia of shiitake (Lentinus edodes) mushrooms. The mycelia are the root-like parts of fungi that grow in the soil or wood, while the mushroom is the fruiting body of the fungi. The shiitake mushroom is also known as Lentinula edodes.
AHCC is a mixture of components derived from cultured mushroom mycelia. It is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects. It also contains a mixture of nutrients, including oligosaccharides, amino acids, and minerals obtained through liquid culture.
AHCC is widely used as a supplement to boost the immune system and has been studied for its potential benefits in cancer, liver disease, and Human Papillomavirus (HPV) treatment. It has been investigated for a variety of applications in more than 100 scientific publications. It is believed to work as an 'immune modulator', orchestrating immune responses and maintaining immune homeostasis.
However, it is important to note that AHCC is not regulated by the FDA in the United States, and there is limited research on its effectiveness as a treatment for cancer, with inconclusive evidence. It may also interact with certain medications, so it is important to consult a healthcare professional before taking AHCC or any other supplement.
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It is used as an immune system booster
Active Hexose Correlated Compound (AHCC) is a supplement derived from the mycelia of shiitake (Lentinus edodes) mushrooms. The mycelia are the root-like parts of fungi that grow in the soil or wood, while the mushroom is the fruiting body of the fungi. AHCC is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects.
AHCC is widely used as an immune system booster. It is believed to act as an immune modulator, enhancing the body's response to infection and increasing survival. Reports in animal and clinical settings have indicated that AHCC is associated with an enhanced response to infection and increased survival. Laboratory research suggests that AHCC may have immunostimulatory effects, and small studies have shown benefits in boosting the immune system. In healthy adults, AHCC improved T-cell immune responses, increased dendritic cell number and function, and improved antibody response to the influenza vaccine. AHCC has also been shown to enhance natural killer cell activity, which plays an important role in host defence against infections and malignancies.
In addition to its immune-boosting properties, AHCC has been studied for its potential role in cancer treatment, liver disease, and Human Papillomavirus (HPV) infection. It has been proposed as a treatment for cancer, with some studies suggesting that it may reduce symptoms, improve survival, and shorten recovery time in animal models infected with viruses, bacteria, and fungal infections. However, research into its effectiveness in cancer treatment has produced uncertain and inconclusive evidence, and further detailed research is needed.
It is important to note that AHCC is a supplement, and supplements should not be used to treat, cure, or prevent diseases. Always speak with a healthcare provider before taking any supplements to ensure that they are appropriate for your individual needs and to discuss potential interactions with foods, other supplements, and medications.
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AHCC is being studied for its role in treating cancer
Active Hexose Correlated Compound (AHCC) is a mixture of components derived from the mycelia of shiitake (Lentinus edodes) mushrooms. The mycelia are the root-like parts of fungi that grow in the soil or wood, while the umbrella-shaped part is the fruiting body or mushroom. AHCC is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects.
AHCC has been studied for its anti-cancer and immune-modulating functions. It has been shown to increase the number and activity of natural killer and T cells, which are vital to the immune system's defence. In a study, AHCC treatment delayed tumour development after inoculation of melanoma and lymphoma cell lines. It also enhanced the anti-tumour effects of 5-fluorouracil by enhancing apoptosis and upregulating expression of BCl-2 associated X protein.
AHCC has also been studied for its ability to reduce the side effects of chemotherapy medications and improve the quality of life for people with advanced cancer. For example, supplementing with AHCC lowered the side effects of the medicine gemcitabine in people with pancreatic cancer. In a small study of 29 people, taking AHCC for up to two years was associated with a decreased risk of cancer recurrence.
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It has been used in traditional Chinese medicine
Mushrooms have been used for centuries in traditional Chinese medicine to modify immunity. The shiitake mushroom, in particular, has been studied for its potential health benefits. Active Hexose Correlated Compound (AHCC) is a proprietary extract derived from the mycelia of shiitake (Lentinus edodes) mushrooms. The mycelia are the root-like parts of fungi that grow in the soil or wood, while the umbrella-shaped part is the fruiting body that we typically eat.
AHCC is a mixture of components derived from cultured mushroom mycelia. It is rich in alpha-1,4-glucan oligosaccharides, which are thought to enhance its biological effects. The polysaccharides in AHCC stimulate specific receptors located on human immune cells in the gut. These polysaccharides may affect innate and adaptive immune responses, leading to potential benefits in health and disease.
In traditional Chinese medicine, mushrooms have been used to boost immunity and treat various ailments. AHCC, derived from shiitake mushrooms, has been studied for its potential to enhance the immune system and provide health benefits. One of the promising applications of AHCC is its potential as a nutritional supplement to help the immune system fight infections, such as Human Papillomavirus (HPV). HPV is a common infection that can lead to cervical cancer in women. Research has shown that AHCC may help clear HPV infections in cervical cancer cell lines and mouse models.
AHCC has also been studied for its potential role in regulating the immune system and treating cancer, liver disease, and HPV. Small studies have shown benefits, but more extensive clinical trials are needed before AHCC can be routinely recommended. In one small trial, AHCC effectively boosted the immune system after four weeks in 36 adults. Another small study found that AHCC suppressed HPV infections after three to six months in 41 females.
While AHCC has been proposed as a treatment for cancer, the research is inconclusive, and more detailed research is needed. It is important to note that AHCC is not a regulated substance like prescription drugs, and supplement products may not contain what is listed on the label. Therefore, it is essential to consult a healthcare professional before taking AHCC or any other supplement to ensure its safety and appropriateness for individual needs.
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AHCC may cause allergic reactions
AHCC (Active Hexose Correlated Compound) is a proprietary blend of medicinal mushroom roots, also known as mycelia, that is used in immune health supplements. The mycelia used in AHCC are derived from the shiitake mushroom, also known as Lentinula edodes.
AHCC is a supplement that has been studied for its potential to boost the immune system and protect against cancer. It has been shown to increase the number and activity of natural killer and T cells, which are vital to the immune system's defense. AHCC has also been studied for its effects on viruses like the flu and the West Nile virus, and cancers like melanoma.
While AHCC has been shown to have potential health benefits, it is important to note that it may cause allergic reactions in some individuals. People with mushroom allergies should proceed with caution when taking AHCC. Although rare, allergic reactions to AHCC have been reported and can be severe. Symptoms of an allergic reaction may include itching, hives, and shortness of breath. If you experience any of these symptoms after taking AHCC, seek immediate medical attention.
The fermentation process used in the manufacturing of AHCC helps to protect against allergic reactions. However, it is not guaranteed to eliminate the risk entirely. Individuals with known mushroom allergies should consult a medical professional before taking AHCC to weigh the potential benefits against the risk of an allergic reaction.
Additionally, it is important to be cautious when taking AHCC in combination with certain medications. While it is unlikely that AHCC will interact negatively with most drugs, there is a small potential for interaction with some medications. Always consult your healthcare provider before taking AHCC, especially if you are currently taking any prescription medications.
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Frequently asked questions
Active Hexose Correlated Compound (AHCC) is a group of chemicals taken from fungi and turned into a supplement. It is believed to boost the immune system and is used to prevent and treat cancer.
AHCC is derived from the mycelia of shiitake (Lentinus edodes) mushrooms.
The recommended dosage of AHCC may vary depending on the purpose of its use. Daily doses are typically between 1 and 3 grams.
AHCC has few reported side effects, but it can interact with cancer medications and other drugs that the liver breaks down. Mushroom-based products like AHCC may also cause hypersensitivity reactions.

























