
While there is limited research on the effects of mixing cocaine and psilocybin (the active compound found in magic mushrooms), some studies suggest that psilocybin may be effective in treating cocaine addiction. However, both substances can increase heart rate and blood pressure, and cocaine has serious side effects and a high potential for addiction. Mixing cocaine with other substances can lead to adverse effects, including overstimulation and physical discomfort, and may increase the risk of severe medical complications. Similarly, magic mushrooms are significantly more dangerous when combined with other substances, and can increase the risk of bad trips, which can lead to frightening and unpleasant physical and mental symptoms. Therefore, it is important to exercise caution when considering the use of these substances, especially in combination.
| Characteristics | Values |
|---|---|
| Mixing Cocaine and Mushrooms | There is limited information available on the effects of this combination |
| Mixing Cocaine and LSD | Can produce undesirable effects like overstimulation and physical discomfort |
| Can lead to rare, sudden death from seizures or cardiac arrest | |
| May result in a "bad trip" with intense psychological effects that are hard to shake off | |
| Mixing Mushrooms and Alcohol | May have unpredictable results and increase the risk of accidents and bodily injury |
| Could lead to a "bad trip" with disturbing hallucinations and unpredictable or panicked behavior | |
| May alter levels of intoxication, leading to increased consumption of both substances | |
| Psilocybin may reduce the perceived effects of alcohol, leading to overconsumption | |
| Treatment for Cocaine Addiction | Researchers are investigating the use of psilocybin, the active compound in magic mushrooms, to help treat cocaine addiction |
| There is no pharmacological option available for cocaine addiction, unlike alcohol or nicotine |
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What You'll Learn

The effects of cocaine and mushrooms together are unknown
It is important to note that the effects of combining cocaine and mushrooms are unknown and there is limited scientific literature on the subject. Mushrooms, or "shrooms", are a psychedelic drug that can cause nausea and anxiety. They are not meant to be taken with any other drugs, especially not stimulants like cocaine, which increase blood pressure and heart rate.
Mixing mushrooms with other drugs can lead to a "bad trip", which includes disturbing hallucinations, extreme fear, anxiety, mental confusion, paranoia, and loss of a sense of reality. The risk of a bad trip is higher when consuming large amounts or strong batches of mushrooms. The effects of a bad trip can last from a few hours to days and sometimes even weeks.
Cocaine has a high potential for addiction and regular use increases the risk of developing a tolerance and dependence. It is also associated with a risk of rare, sudden death from seizures or cardiac arrest. Combining cocaine with other drugs can be dangerous and has unpredictable results. For example, mixing cocaine with alcohol produces a high amount of cocaethylene, which greatly increases the risk of cardiovascular toxicity.
While there is limited research on the effects of combining cocaine and mushrooms, researchers at the University of Alabama at Birmingham are conducting a clinical trial to investigate whether psilocybin, the active compound in mushrooms, can help individuals addicted to cocaine stop using the drug. Participants in the trial are given a dose of psilocybin and then monitored for six hours. After the effects of psilocybin wear off, researchers track the participant's cocaine use. This research suggests that psilocybin may have potential in treating cocaine addiction.
In conclusion, the effects of combining cocaine and mushrooms are currently unknown, and it is important to approach this combination with caution due to the potential risks associated with both drugs. It is always advisable to consult with a healthcare professional before consuming any substance, especially when mixing different drugs.
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Cocaine and mushrooms both increase heart rate
Psychedelic and hallucinogenic drugs have become a significant public health concern, especially with their increasing use among adolescents and young adults. While these drugs are known to have certain therapeutic benefits, their cardiovascular safety remains a concern.
Psilocybin and Heart Rate
Psilocybin, the active ingredient in "magic mushrooms", has been shown to increase heart rate and blood pressure. These cardiovascular effects are transient, dose-dependent, and typically do not require medical intervention. However, there have been rare cases of more serious adverse events associated with psilocybin use, including cardiac arrest and acute kidney injury.
Cocaine and Heart Rate
Cocaine is a stimulant that increases heart rate and body temperature. It also has a high potential for addiction, with regular use increasing the risk of tolerance and dependence. Rare sudden death can occur from cocaine use, often resulting from seizures or cardiac arrest.
Mixing Substances
Mixing cocaine with other substances, such as LSD or alcohol, can lead to undesirable effects and increase the risk of adverse outcomes. The combination of cocaine and alcohol produces a unique substance called cocaethylene, which significantly increases the risk of cardiovascular toxicity.
In conclusion, both cocaine and psilocybin mushrooms can increase heart rate and have the potential to cause serious cardiovascular events, especially when mixed with other substances. It is important to be aware of these risks and to seek professional advice before consuming any of these substances.
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Mushrooms have the lowest risk profile of any recreational drug
While cocaine is a powerful stimulant that can induce a sense of euphoria and increased energy, it also carries significant risks and side effects. Mixing cocaine with other substances, including alcohol, can be particularly dangerous and may lead to adverse effects such as overstimulation and physical discomfort. Cocaine has a high potential for addiction, and regular use can increase the risk of developing tolerance and dependence. Additionally, the risk of rare, sudden death is present, even with first-time use, often resulting from seizures or cardiac arrest.
On the other hand, mushrooms, particularly "magic mushrooms" or "shrooms," have been associated with a lower risk profile compared to other recreational drugs. According to the 2017 Global Drug Survey, out of 12,000 people who consumed psilocybin hallucinogenic mushrooms, only 0.2% reported seeking emergency medical treatment, a significantly lower rate than that of other drugs such as MDMA, LSD, cocaine, and synthetic cannabis. The survey also revealed that the primary reasons for mushroom users seeking medical attention included accidental injury, panic, short-lived confusion, disorientation, and fears of losing one's mind.
One of the biggest risks associated with mushroom consumption is the potential for poisoning if the wrong type of mushroom is ingested. However, this risk can be mitigated by correctly identifying the mushrooms and choosing a safe and familiar environment when taking them. Additionally, it is important to note that combining mushrooms with alcohol can increase the risks of harm, as alcohol is a depressant that can interact with the psychedelic effects of mushrooms.
While no drug use is entirely without risk, mushrooms have been consistently ranked as one of the safest recreational drugs available. They have shown potential in clinical trials for treating severe depression, anxiety, and post-traumatic stress disorder. Furthermore, mushrooms are not typically associated with abuse or dependence, and their impact on organ health is significantly less detrimental than that of many other substances. As a result, mushrooms are often considered to have the lowest risk profile of any recreational drug.
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Cocaine has a high potential for addiction
Cocaine is a highly addictive stimulant drug that can have severe and long-lasting impacts on a person's physical and mental health. It is made from the leaves of the coca plant, which is native to South America. Cocaine use can lead to serious medical complications, including cocaine use disorder, overdose, and even death. The drug has a high potential for misuse, and regular use can increase the risk of developing tolerance and dependence.
The high from cocaine is very pleasurable but short-lived, often lasting only a few minutes to a couple of hours. This can lead to a cycle of repeated use as individuals seek to prolong the good feelings and avoid the unpleasant comedown. Over time, this can result in cocaine use disorder, characterised by compulsive cravings and a loss of control over substance use. Individuals with cocaine use disorder may develop both physical and mental dependence on the drug, and quitting can be challenging due to the presence of withdrawal symptoms. Even after long periods of abstinence, cravings for cocaine may persist.
The addictive nature of cocaine can be attributed to its impact on the brain's reward system. Cocaine increases the levels of dopamine, a natural chemical messenger associated with pleasure and reward, in the brain regions that control pleasure. This dopamine buildup leads to intense feelings of energy and alertness, resulting in the characteristic high. However, as cocaine use continues, the structures in the brain's reward system undergo changes, fostering compulsive drug-seeking behaviour and a loss of control over substance use.
The potential for addiction is heightened by the fact that cocaine use can have a ripple effect on various aspects of an individual's life. It can strain relationships, impair daily functioning, and increase the risk of contracting infections such as HIV and hepatitis C, especially if needles are shared. Additionally, cocaine use during pregnancy can have detrimental effects on both the mother and the developing baby, including an increased risk of premature delivery, low birth weight, and cardiovascular complications.
While treatments for cocaine use disorder exist, such as cognitive-behavioral therapy, relapse rates are high. The powerful addictive qualities of cocaine underscore the importance of prevention and early intervention. Seeking help from medical and mental health professionals is crucial for individuals struggling with cocaine addiction. Additionally, supportive services like helplines and support groups can provide valuable assistance to those affected by cocaine use.
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Mixing mushrooms with alcohol may be unpredictable
Mixing mushrooms with alcohol may lead to unpredictable results and is considered a high-risk combination. Both substances can have complex and unpredictable effects on the CNS and may amplify, diminish, or alter each other's effects in unforeseen ways. The interplay between the two substances can bring about unexpected and adverse reactions, posing threats to both physical and mental well-being.
Alcohol is a depressant, and mushrooms are hallucinogenic psychedelics. When consumed together, the results can be unpredictable. Alcohol has the potential to intensify the effects of mushrooms, leading to overwhelming hallucinations, confusion, and paranoia. This heightened state of altered consciousness can be disorienting and distressing, potentially triggering panic attacks or extreme unease. The combination may also impair one's ability to gauge their state of mind, leading to poor decision-making and an increased risk of harm.
The immediate pleasurable side effects of mushrooms are often enhanced when alcohol is consumed simultaneously. This intensification of effects can lead to a heightened sense of euphoria and excitement. However, it is important to note that the mushrooms may also mask the effects of alcohol, causing individuals to consume more alcohol than is safe. Additionally, the comedown from alcohol can amplify any negative emotions brought on by the psychedelic experience, leading to intensified emotional states such as anxiety or depression.
Mixing mushrooms with alcohol can increase the risk of a "bad trip." During a bad trip, individuals may experience hallucinations, frightening emotions, nausea, panic attacks, and negative emotions. It can be challenging to distinguish between fantasy and reality, and impaired judgment from alcohol may lead to unsafe activities and risky behaviours. The combination of these substances can make it more difficult to think clearly, and there may be adverse health effects and long-term damaging effects on the body.
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Frequently asked questions
Taking cocaine during a mushroom trip can be dangerous. Both substances increase heart rate and blood pressure, and the combination can cause hypertension and tachycardia. There is also a risk of serotonin syndrome, which can be fatal.
Cocaine may reduce the effects of mushrooms, but it will not sober you up. The only way to sober up is to wait for your body to metabolize the mushrooms.
The combination of cocaine and mushrooms is not well studied, but it is known that both substances increase heart rate and blood pressure, so mixing them may increase the risk of severe medical complications.
There are no credible reports of lethal mushroom overdoses, but a "bad trip" can cause extreme fear, anxiety, mental confusion, paranoia, and loss of a sense of reality.
Researchers at the University of Alabama at Birmingham are investigating whether psilocybin, the active compound in mushrooms, can help treat cocaine addiction. However, it is important to note that mixing cocaine and mushrooms can be dangerous and may not be an effective treatment.

























